Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Mickaël Guedj"'
A new molecular classification to drive precision treatment strategies in primary Sjögren’s syndrome
Autor:
Perrine Soret, Christelle Le Dantec, Emiko Desvaux, Nathan Foulquier, Bastien Chassagnol, Sandra Hubert, Christophe Jamin, Guillermo Barturen, Guillaume Desachy, Valérie Devauchelle-Pensec, Cheïma Boudjeniba, Divi Cornec, Alain Saraux, Sandrine Jousse-Joulin, Nuria Barbarroja, Ignasi Rodríguez-Pintó, Ellen De Langhe, Lorenzo Beretta, Carlo Chizzolini, László Kovács, Torsten Witte, PRECISESADS Clinical Consortium, PRECISESADS Flow Cytometry Consortium, Eléonore Bettacchioli, Anne Buttgereit, Zuzanna Makowska, Ralf Lesche, Maria Orietta Borghi, Javier Martin, Sophie Courtade-Gaiani, Laura Xuereb, Mickaël Guedj, Philippe Moingeon, Marta E. Alarcón-Riquelme, Laurence Laigle, Jacques-Olivier Pers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Sjögren’s syndrome, a disease that primarily affects women, is poorly understood. Here, the authors combine data from a large cohort of patients and healthy controls to identify biomarkers that distinguish patient subgroups to improve our understa
Externí odkaz:
https://doaj.org/article/fd749685034f43a3afc45a40aaefddd7
Autor:
Olivier Imbert, Damien Chimits, Mickaël Guedj, Freddy Lorieau, Katy Bernard, Agnès Lalande, Wolfgang Wirth, Felix Eckstein, Maria Pueyo
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 3, Iss 3, Pp 100188- (2021)
Objectives: Selection of patients with KL radiographic grade 2 and 3 is widely used in clinical trials, but this approach could have some limitations. The purpose of this study performed on OsteoArthritis Initiative (OAI) data is to assess whether ad
Externí odkaz:
https://doaj.org/article/e6fb5dc6cdcd4c0ebe2299168910c630
Autor:
Emiko Desvaux, Antoine Hamon, Sandra Hubert, Cheïma Boudjeniba, Bastien Chassagnol, Jack Swindle, Audrey Aussy, Laurence Laigle, Jessica Laplume, Perrine Soret, Pierre Jean-François, Isabelle Dupin-Roger, Mickaël Guedj, Philippe Moingeon
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254374 (2021)
While establishing worldwide collective immunity with anti SARS-CoV-2 vaccines, COVID-19 remains a major health issue with dramatic ensuing economic consequences. In the transition, repurposing existing drugs remains the fastest cost-effective approa
Externí odkaz:
https://doaj.org/article/5fd1b6a21aec44c0adf1f01f863bbdaf
Autor:
Wenjia Wang, Mickaël Guedj, Viviane Bertrand, Julie Foucquier, Elisabeth Jouve, Daniel Commenges, Cécile Proust-Lima, Niall P Murphy, Olivier Blin, Laurent Magy, Daniel Cohen, Shahram Attarian
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169878 (2017)
The Charcot-Marie-Tooth Neuropathy Score (CMTNS) was developed as a main efficacy endpoint for application in clinical trials of Charcot-Marie-Tooth disease type 1A (CMT1A). However, the sensitivity of the CMTNS for measuring disease severity and pro
Externí odkaz:
https://doaj.org/article/1ed5e395f7894e9c845085b6ded2e1f7
Autor:
Wenjia Wang, Jonas Mandel, Jan Bouaziz, Daniel Commenges, Serguei Nabirotchkine, Ilya Chumakov, Daniel Cohen, Mickaël Guedj, Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138223 (2015)
Results from Genome-Wide Association Studies (GWAS) have shown that the genetic basis of complex traits often include many genetic variants with small to moderate effects whose identification remains a challenging problem. In this context multi-marke
Externí odkaz:
https://doaj.org/article/1b4e159fc6d74b7aab5ad1f2305dbd7f
Autor:
Serguei, Nabirotchkin, Jan, Bouaziz, Fabrice, Glibert, Jonas, Mandel, Julie, Foucquier, Rodolphe, Hajj, Noëlle, Callizot, Nathalie, Cholet, Mickaël, Guedj, Daniel, Cohen
Publikováno v:
Journal of Alzheimer's Disease. 88:1585-1603
Background: Human diseases are multi-factorial biological phenomena resulting from perturbations of numerous functional networks. The complex nature of human diseases explains frequently observed marginal or transitory efficacy of mono-therapeutic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3689c941909510a2251ed0bd5d8421b6
https://doi.org/10.3233/jad-220120
https://doi.org/10.3233/jad-220120
Autor:
Mickaël Guedj, Jack Swindle, Antoine Hamon, Sandra Hubert, Emiko Desvaux, Jessica Laplume, Laura Xuereb, Céline Lefebvre, Yannick Haudry, Christine Gabarroca, Audrey Aussy, Laurence Laigle, Isabelle Dupin-Roger, Philippe Moingeon
Publikováno v:
Expert Opinion on Drug Discovery. 17:815-824
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21dfb81e651704a575ffafcb583a9e4b
https://doi.org/10.1080/17460441.2022.2095368
https://doi.org/10.1080/17460441.2022.2095368
Publikováno v:
Drug Discovery Today. 27:215-222
Artificial Intelligence (AI) relies upon a convergence of technologies with further synergies with life science technologies to capture the value of massive multi-modal data in the form of predictive models supporting decision-making. AI and machine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a957e72304d36e8a4de1470bb43488bd
https://doi.org/10.1016/j.drudis.2021.09.006
https://doi.org/10.1016/j.drudis.2021.09.006
Autor:
Laurence Laigle, Christelle Le Dantec, Perrine Soret, Emiko Desvaux, Sandra Hubert, Nathan Foulquier, Philippe Moingeon, Mickaël Guedj, Jacques-Olivier Pers
Publikováno v:
médecine/sciences
médecine/sciences, 2022, 38 (2), pp.148-151. ⟨10.1051/medsci/2021258⟩
médecine/sciences, 2022, 38 (2), pp.148-151. ⟨10.1051/medsci/2021258⟩
International audience; No abstract available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139506a924e6dbf23ec8ca11f9a87fcd
https://hal.science/hal-03581011/document
https://hal.science/hal-03581011/document
Autor:
Emiko Desvaux, Perrine Soret, Mickaël Guedj, Jacques-Olivier Pers, Philippe Moingeon, Alexia Blesius, Sandra Hubert, Laurence Laigle, Florence Keime-Guibert, Audrey Aussy
Publikováno v:
Expert review of clinical immunology. 18(1)
INTRODUCTION The complex pathophysiology of autoimmune diseases (AIDs) is being progressively deciphered, providing evidence for a multiplicity of pro-inflammatory pathways underlying heterogeneous clinical phenotypes and disease evolution.Areas cove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a618d8fee98f7f7625d9ea86e2dc380a
https://pubmed.ncbi.nlm.nih.gov/34842494
https://pubmed.ncbi.nlm.nih.gov/34842494