Výsledky vyhledávání - "Mickaël, Terme"

Identification of 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac2) as main O-acetylated sialic acid species of GD2 in breast cancer cells

Autor: Jean-Marc Le Doussal, Justine H. Dewald, Philippe Delannoy, Sophie Groux-Degroote, Yann Guérardel, Nao Yamakawa, Mickaël Terme, Sumeyye Cavdarli

Publikováno v: Glycoconjugate Journal. 36:79-90

Mainly restricted to the nervous system in healthy adults, complex gangliosides such as GD3 and GD2 have been shown to be involved in aggressiveness and metastasis of neuro-ectoderm derived tumors such as melanoma and neuroblastoma. Interestingly, O-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::915d39446b85407f31a659f5fcf5aa41
https://doi.org/10.1007/s10719-018-09856-w

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Akademický článek

Chimeric antibody c.8B6 to O-acetyl-GD2 mediates the same efficient anti-neuroblastoma effects as therapeutic ch14.18 antibody to GD2 without antibody induced allodynia.

Autor: Mickaël Terme, Mylène Dorvillius, Denis Cochonneau, Tanguy Chaumette, Wenhua Xiao, Mitchell B Diccianni, Jacques Barbet, Alice L Yu, François Paris, Linda S Sorkin, Stéphane Birklé

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87210 (2014)

Anti-GD2 antibody is a proven therapy for GD2-positive neuroblastoma. Monoclonal antibodies against GD2, such as chimeric mAb ch14.18, have become benchmarks for neuroblastoma therapies. Pain, however, can limit immunotherapy with anti-GD2 therapeuti

Externí odkaz: https://doaj.org/article/3b49ad6202ac4463bff6f98234611e69

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O-acetylated gangliosides: Structure, biosynthesis, immunogenicity, functions and their potential for cancer immunotherapy

Autor: Mickaël Terme, Sébastien Faraj, Marc-David Leclair, Sophie Fougeray, Julien Fleurence, Denis Cochonneau, Stéphane Birklé, Estelle Thébaud, François Paris, Meriem Bahri

Publikováno v: Journal of Cancer Research and Therapeutics
Journal of Cancer Research and Therapeutics, 2016, 4 (3), pp.21-30. ⟨10.14312/2052-4994.2016-5⟩
Journal of Cancer Research & Therapy, Vol 4, Iss 3, Pp 21-30 (2016)
Journal of Cancer Research and Therapeutics, Medknow Publications, 2016, 4 (3), pp.21-30. ⟨10.14312/2052-4994.2016-5⟩

International audience; Sialic acid O-acetylation is a developmentally regulated modification of gangliosides implicated in ontogeny and tumor progression. Their existence has been underestimated in the past because of their alkali-labile nature and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82ab680dbfba961ee02096b2c81721b
https://doi.org/10.14312/2052-4994.2016-5

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Identification of 9-O-acetyl-N-acetylneuraminic acid (Neu5,9Ac

Autor: Sumeyye, Cavdarli, Justine H, Dewald, Nao, Yamakawa, Yann, Guérardel, Mickaël, Terme, Jean-Marc, Le Doussal, Philippe, Delannoy, Sophie, Groux-Degroote

Publikováno v: Glycoconjugate journal. 36(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::918b129ecb200ed06aefe780ebb124f6
https://pubmed.ncbi.nlm.nih.gov/30612272

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Chimeric Antibody c.8B6 to O-Acetyl-GD2 Mediates the Same Efficient Anti-Neuroblastoma Effects as Therapeutic ch14.18 Antibody to GD2 without Antibody Induced Allodynia

Autor: Mylène Dorvillius, Alice L. Yu, Mitchell B. Diccianni, Stéphane Birklé, Denis Cochonneau, François Paris, Jacques Barbet, Mickaël Terme, Tanguy Chaumette, Linda S. Sorkin, Wen-hua Xiao

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 2, p e87210 (2014)

Background: Anti-GD2 antibody is a proven therapy for GD2-postive neuroblastoma. Monoclonal antibodies against GD2, such as chimeric mAb ch14.18, have become benchmarks for neuroblastoma therapies. Pain, however, can limit immunotherapy with anti-GD2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5e82004431c562d67bb8ddc060942f
http://europepmc.org/articles/PMC3919714

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Cell cycle arrest and apoptosis induced by O-acetyl-GD2-specific monoclonal antibody 8B6 inhibits tumor growth in vitro and in vivo

Autor: Mylène Dorvillius, Jacques Aubry, Nidia Alvarez-Rueda, Nicolas Gautier, Jihane Frikeche, Gwenola Bougras, Stéphane Birklé, Mickaël Terme, Alexis Michaud, François Paris, Denis Cochonneau

Publikováno v: Cancer letters. 333(2)

O-Acetyl-GD2 ganglioside is suitable antigen for tumor immunotherapy with specific therapeutic antibody. Here, we investigate the anti-tumor activity of O-acetyl-GD2-specific monoclonal antibody 8B6 on O-acetyl-GD2-positive tumor cells. The results i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56aeec6a7df79933a84ae30452a4018e
https://pubmed.ncbi.nlm.nih.gov/23370223

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