Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mick T Rae"'
Autor:
Jella Wauters, Kirsten S Wilson, Tim Bouts, Iain Valentine, Koen Vanderschueren, Cyrillus Ververs, A Forbes Howie, Mick T Rae, Ann Van Soom, Rengui Li, Desheng Li, Hemin Zhang, Lynn Vanhaecke
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0201420 (2018)
Reproductive monitoring for captive breeding in giant pandas is based on behavioural observation and non-invasive hormone analysis. In urine, interpretation of results requires normalisation due to an animal's changing hydration. Correction of urinar
Externí odkaz:
https://doaj.org/article/e035a0c1eb874ed0bb926644519d5c2b
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185664 (2017)
Stroke causes severe neuronal damage as disrupted cerebral blood flow starves neurons of oxygen and glucose. The hypoxia inducible factors (HIF-1α and HIF-2α) orchestrate oxygen homeostasis and regulate specific aspects of hypoxic adaptation. Here
Externí odkaz:
https://doaj.org/article/f8d512d5339a4bd68eeac869cb192388
Autor:
Nick Wheelhouse, Christopher Coyle, Peter G Barlow, Stephen Mitchell, Gilbert Greub, Tim Baszler, Mick T Rae, David Longbottom
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102386 (2014)
Waddlia chondrophila (W. chondrophila) is an emerging abortifacient organism which has been identified in the placentae of humans and cattle. The organism is a member of the order Chlamydiales, and shares many similarities at the genome level and in
Externí odkaz:
https://doaj.org/article/324a39e916814e61b41d08fd085fc486
Autor:
Katarzyna J. Siemienowicz, Yili Wang, Magda Marečková, Junko Nio-Kobayashi, Paul A. Fowler, Mick T. Rae, W. Colin Duncan
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Maternal exposure to increased steroid hormones, including estrogens, androgens or glucocorticoids during pregnancy results in chronic conditions in offspring that manifest in adulthood. Little is known about effects of progesterone administ
Externí odkaz:
https://doaj.org/article/f3674f2be6cf4291a7eee02f7f0513c8
Autor:
Katarzyna J. Siemienowicz, Panagiotis Filis, Sophie Shaw, Alex Douglas, Jennifer Thomas, Sally Mulroy, Forbes Howie, Paul A. Fowler, W. Colin Duncan, Mick T. Rae
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Abstract Androgen signalling is a critical driver of male development. Fetal steroid signalling can be dysregulated by a range of environmental insults and clinical conditions. We hypothesised that poor adult male health was partially attributable to
Externí odkaz:
https://doaj.org/article/ee541a7cd4c64f42a9378b61e15ec36b
Autor:
Katarzyna J. Siemienowicz, Panagiotis Filis, Jennifer Thomas, Paul A. Fowler, W. Colin Duncan, Mick T. Rae
Publikováno v:
Biomedicines, Vol 10, Iss 6, p 1291 (2022)
First-degree male relatives of polycystic ovary syndrome (PCOS) sufferers can develop metabolic abnormalities evidenced by elevated circulating cholesterol and triglycerides, suggestive of a male PCOS equivalent. Similarly, male sheep overexposed to
Externí odkaz:
https://doaj.org/article/490740ad0d364241b1246c146d1cd22c
Autor:
Deborah Price, Brian R. Walker, Mick T Rae, J. Ian Mason, Stephen G. Hillier, Amirah Mohamad, Hilary O. D. Critchley, Patrick W. F. Hadoke
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 94:1443-1450
Heavy menstrual bleeding (HMB; menorrhagia) impairs quality of life for women and requires medication or surgery. Because glucocorticoids inhibit angiogenesis in other organs, we hypothesized that endometrium of women with HMB is subject to decreased
Autor:
Hilary O. D. Critchley, Stephen Hillier, A Kostogiannou, Oliver Gubbay, Deborah Price, Mick T Rae
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:322-327
Context: Ovarian surface epithelial (OSE) cells express multiple nuclear hormone receptor genes, including those encoding thyroid hormone and estrogen receptors (TR and ER, respectively). Ovarian cancer is hormone-dependent, and epidemiological evide
Publikováno v:
Journal of Endocrinology. 191:275-285
cAMP response-element binding (CREB) transcription factors transduce cell survival responses to peptide hormones and growth factors in normal tissues and mutant CREB proteins are implicated in tumorigenesis. Ovarian cancer most frequently arises from
Publikováno v:
Gubbay, O, Guo, W, Rae, M T, Niven, D, Langdon, S P & Hillier, S G 2005, ' Inflammation-associated gene expression is altered between normal human ovarian surface epithelial cells and cell lines derived from ovarian adenocarcinomas ', British Journal of Cancer, vol. 92, no. 10, pp. 1927-33 . https://doi.org/10.1038/sj.bjc.6602568
British Journal of Cancer
British Journal of Cancer
Ovulation is believed to contribute to the development of ovarian cancers that derive from the ovarian surface epithelium (OSE). The process of ovulation is synonymous with inflammation and inflammatory cytokines such as interleukin-1alpha (IL-1alpha