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Emerging principles of primary cilia dynamics in controlling tissue organization and function.

Autor: Gopalakrishnan J; Institute for Human Genetics, Heinrich-Heine-Universität, Universitätsklinikum Düsseldorf, Düsseldorf, Germany., Feistel K; Department of Zoology, Institute of Biology, University of Hohenheim, Stuttgart, Germany., Friedrich BM; Cluster of Excellence Physics of Life, TU Dresden, Dresden, Germany., Grapin-Botton A; Cluster of Excellence Physics of Life, TU Dresden, Dresden, Germany.; Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.; Paul Langerhans Institute Dresden of the Helmholtz Center Munich at The University Hospital Carl Gustav Carus and Faculty of Medicine of the TU Dresden, Dresden, Germany., Jurisch-Yaksi N; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Mass E; Life and Medical Sciences Institute, Developmental Biology of the Immune System, University of Bonn, Bonn, Germany., Mick DU; Center for Molecular Signaling (PZMS), Center of Human and Molecular Biology (ZHMB), Saarland School of Medicine, Homburg, Germany., Müller RU; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., May-Simera H; Institute of Molecular Physiology, Johannes Gutenberg-University, Mainz, Germany., Schermer B; Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Schmidts M; Pediatric Genetics Division, Center for Pediatrics and Adolescent Medicine, University Hospital Freiburg, Freiburg, Germany.; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany., Walentek P; CIBSS-Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany.; Renal Division, Internal Medicine IV, Medical Center, University of Freiburg, Freiburg, Germany., Wachten D; Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany.

Publikováno v: The EMBO journal [EMBO J] 2023 Nov 02; Vol. 42 (21), pp. e113891. Date of Electronic Publication: 2023 Sep 25.

A cAMP signalosome in primary cilia drives gene expression and kidney cyst formation.

Autor: Hansen JN; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Kaiser F; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Leyendecker P; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Stüven B; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Krause JH; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Derakhshandeh F; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Irfan J; Mironid Ltd., SIPBS, Glasgow, Scotland, UK., Sroka TJ; Center for Molecular Signaling (PZMS), Center of Human and Molecular Biology (ZHMB), Saarland University, School of Medicine, Homburg, Germany., Preval KM; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Biotech II, Worcester, MA, USA., Desai PB; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Biotech II, Worcester, MA, USA., Kraut M; Precise Platform for Single Cell Genomics and Epigenomics, Department of Systems Medicine, German Center for Neurogenerative Diseases, Bonn, Germany., Theis H; Precise Platform for Single Cell Genomics and Epigenomics, Department of Systems Medicine, German Center for Neurogenerative Diseases, Bonn, Germany., Drews AD; Precise Platform for Single Cell Genomics and Epigenomics, Department of Systems Medicine, German Center for Neurogenerative Diseases, Bonn, Germany., De-Domenico E; Precise Platform for Single Cell Genomics and Epigenomics, Department of Systems Medicine, German Center for Neurogenerative Diseases, Bonn, Germany., Händler K; Precise Platform for Single Cell Genomics and Epigenomics, Department of Systems Medicine, German Center for Neurogenerative Diseases, Bonn, Germany., Pazour GJ; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Biotech II, Worcester, MA, USA., Henderson DJP; Mironid Ltd., SIPBS, Glasgow, Scotland, UK., Mick DU; Center for Molecular Signaling (PZMS), Center of Human and Molecular Biology (ZHMB), Saarland University, School of Medicine, Homburg, Germany., Wachten D; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.

Publikováno v: EMBO reports [EMBO Rep] 2022 Aug 03; Vol. 23 (8), pp. e54315. Date of Electronic Publication: 2022 Jun 13.

Time-resolved proteomics profiling of the ciliary Hedgehog response.

Autor: May EA; Center of Human and Molecular Biology, Saarland University School of Medicine, Homburg, Germany., Kalocsay M; Department of Systems Biology, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA.; Department of Cell Biology, Harvard Medical School, Boston, MA., D'Auriac IG; Department of Ophthalmology, University of California, San Francisco, San Francisco, CA., Schuster PS; Center of Human and Molecular Biology, Saarland University School of Medicine, Homburg, Germany., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA., Nachury MV; Department of Ophthalmology, University of California, San Francisco, San Francisco, CA., Mick DU; Center of Human and Molecular Biology, Saarland University School of Medicine, Homburg, Germany.; Center for Molecular Signaling, Department of Medical Biochemistry and Molecular Biology, Saarland University School of Medicine, Homburg, Germany.

Publikováno v: The Journal of cell biology [J Cell Biol] 2021 May 03; Vol. 220 (5).

Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium.

Autor: Hansen JN; Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany., Kaiser F; Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany., Klausen C; Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany., Stüven B; Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany., Chong R; Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany., Bönigk W; Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Bonn, Germany., Mick DU; Center for Molecular Signaling (PZMS), Center of Human and Molecular Biology (ZHMB), Saarland University, School of Medicine, Homburg, Germany., Möglich A; Lehrstuhl für Biochemie, Universität Bayreuth, Bayreuth, Germany.; Research Center for Bio-Macromolecules, Universität Bayreuth, Bayreuth, Germany.; Bayreuth Center for Biochemistry & Molecular Biology, Universität Bayreuth, Bayreuth, Germany., Jurisch-Yaksi N; Kavli Institute for Systems Neuroscience and Centre for Neural Computation, The Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Neurology and Clinical Neurophysiology, St. Olavs University Hospital, Trondheim, Norway., Schmidt FI; Institute of Innate Immunity, Emmy Noether research group, Medical Faculty, University of Bonn, Bonn, Germany.; Core Facility Nanobodies, University of Bonn, Bonn, Germany., Wachten D; Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany.; Research Group Molecular Physiology, Center of Advanced European Studies and Research (caesar), Bonn, Germany.

Publikováno v: ELife [Elife] 2020 Jun 24; Vol. 9. Date of Electronic Publication: 2020 Jun 24.