Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Michiyo Okamoto"'
Autor:
Keiko Nakano, Michiyo Okamoto, Azusa Takahashi-Nakaguchi, Kaname Sasamoto, Masashi Yamaguchi, Hiroji Chibana
Publikováno v:
Journal of Fungi, Vol 9, Iss 10, p 1035 (2023)
With only four classes of antifungal drugs available for the treatment of invasive systemic fungal infections, the number of resistant fungi is increasing, highlighting the urgent need for novel antifungal drugs. Ergosterol, an essential component of
Externí odkaz:
https://doaj.org/article/7a5e3893c12647179910d44d1feccd5c
Autor:
Mafalda Cavalheiro, Diana Pereira, Cécile Formosa-Dague, Carolina Leitão, Pedro Pais, Easter Ndlovu, Romeu Viana, Andreia I. Pimenta, Rui Santos, Azusa Takahashi-Nakaguchi, Michiyo Okamoto, Mihaela Ola, Hiroji Chibana, Arsénio M. Fialho, Geraldine Butler, Etienne Dague, Miguel C. Teixeira
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Mafalda Cavalheiro et al. use single-cell force spectroscopy and RNA-seq to examine the adhesion process of Candida glabrata, an opportunistic human fungal pathogen, to various medical surfaces. Their results suggest that the adhesion forces of C. gl
Externí odkaz:
https://doaj.org/article/a3c1846e2a0444b58853c7ecafecb7f2
Autor:
Maiko Kiyohara, Taiga Miyazaki, Michiyo Okamoto, Tatsuro Hirayama, Koichi Makimura, Hiroji Chibana, Nana Nakada, Yuya Ito, Makoto Sumiyoshi, Nobuyuki Ashizawa, Kazuaki Takeda, Naoki Iwanaga, Takahiro Takazono, Koichi Izumikawa, Katsunori Yanagihara, Shigeru Kohno, Hiroshi Mukae
Publikováno v:
Journal of Fungi, Vol 9, Iss 5, p 529 (2023)
Outbreaks of invasive infections, with high mortality rates, caused by multidrug-resistant Candida auris have been reported worldwide. Although hotspot mutations in FKS1 are an established cause of echinocandin resistance, the actual contribution of
Externí odkaz:
https://doaj.org/article/609dd914f49948b5aa9ec68582cb7c74
Autor:
Pedro Pais, Susana Vagueiro, Dalila Mil-Homens, Andreia I. Pimenta, Romeu Viana, Michiyo Okamoto, Hiroji Chibana, Arsénio M. Fialho, Miguel C. Teixeira
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 1522-1538 (2020)
Candida glabrata is a prominent pathogenic yeast which exhibits a unique ability to survive the harsh environment of host immune cells. In this study, we describe the role of the transcription factor encoded by the gene CAGL0F09229g, here named CgTog
Externí odkaz:
https://doaj.org/article/2f9722627f254045840f9e3363b6af92
Autor:
Michiyo Okamoto, Azusa Takahashi-Nakaguchi, Kengo Tejima, Kaname Sasamoto, Masashi Yamaguchi, Toshihiro Aoyama, Minoru Nagi, Kohichi Tanabe, Yoshitsugu Miyazaki, Hironobu Nakayama, Chihiro Sasakawa, Susumu Kajiwara, Alistair J. P. Brown, Miguel C. Teixeira, Hiroji Chibana
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The uptake of cholesterol from the host is closely linked to the proliferation of pathogenic fungi and protozoa during infection. For some pathogenic fungi, cholesterol uptake is an important strategy for decreasing susceptibility to antifungals that
Externí odkaz:
https://doaj.org/article/032d13171c144ec89662613b0415c996
Autor:
Michiyo Okamoto, Keiko Nakano, Azusa Takahashi-Nakaguchi, Kaname Sasamoto, Masashi Yamaguchi, Miguel Cacho Teixeira, Hiroji Chibana
Publikováno v:
Journal of Fungi, Vol 9, Iss 2, p 240 (2023)
Mitochondrial dysfunction or morphological abnormalities in human pathogenic fungi are known to contribute to azole resistance; however, the underlying molecular mechanisms are unknown. In this study, we investigated the link between mitochondrial mo
Externí odkaz:
https://doaj.org/article/dfc649e4cb3e4deb91035884946e46a7
Autor:
Rui Santos, Mafalda Cavalheiro, Catarina Costa, Azusa Takahashi-Nakaguchi, Michiyo Okamoto, Hiroji Chibana, Miguel C. Teixeira
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Biofilm formation and drug resistance are two key pathogenesis traits exhibited by Candida glabrata as a human pathogen. Interestingly, specific pathways appear to be in the crossroad between the two phenomena, making them promising targets for drug
Externí odkaz:
https://doaj.org/article/d27488fa95ae4e2b8060b803f7359ab3
Autor:
Pedro Pais, Mónica Galocha, Raquel Califórnia, Romeu Viana, Mihaela Ola, Michiyo Okamoto, Hiroji Chibana, Geraldine Butler, Miguel C. Teixeira
Publikováno v:
Journal of Fungi, Vol 8, Iss 1, p 61 (2022)
The prevalence of antifungal resistance in Candida glabrata, especially against azole drugs, results in difficult-to-treat and potentially life-threatening infections. Understanding the molecular basis of azole resistance in C. glabrata is crucial to
Externí odkaz:
https://doaj.org/article/d47f384cbc984e3fbd5cbd4506014df5
Autor:
Ruben T. Bernardo, Diana V. Cunha, Can Wang, Leonel Pereira, Sónia Silva, Sara B. Salazar, Markus S. Schröder, Michiyo Okamoto, Azusa Takahashi-Nakaguchi, Hiroji Chibana, Toshihiro Aoyama, Isabel Sá-Correia, Joana Azeredo, Geraldine Butler, Nuno Pereira Mira
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 7, Iss 1, Pp 1-18 (2017)
To thrive in the acidic vaginal tract, Candida glabrata has to cope with high concentrations of acetic acid. The mechanisms underlying C. glabrata tolerance to acetic acid at low pH remain largely uncharacterized. In this work, the essential role of
Externí odkaz:
https://doaj.org/article/b6bab08031f340d0a6e4921c56817f25
Autor:
Romeu Viana, Hiroji Chibana, Dalila Mil-Homens, Miguel C. Teixeira, Pedro Pais, Susana Vagueiro, Arsenio M. Fialho, Andreia I. Pimenta, Michiyo Okamoto
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 1522-1538 (2020)
Candida glabrata is a prominent pathogenic yeast which exhibits a unique ability to survive the harsh environment of host immune cells. In this study, we describe the role of the transcription factor encoded by the gene CAGL0F09229g, here named CgTog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc32934c026218a6ab97f1cc9dfa5668
https://doaj.org/article/2f9722627f254045840f9e3363b6af92
https://doaj.org/article/2f9722627f254045840f9e3363b6af92