Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michitada Sasajima"'
Publikováno v:
Folia Pharmacologica Japonica. 74:193-205
The inhibitory effect of D-penicillamine on the denaturation of human gamma-globulin induced by heat and Cu++ was compared with the action of other agents such as antirheumatic drugs, anti-inflammatory drugs, SH reagents, SH inhibitors and chelating
Autor:
Yasuo TARUMOTO, Satoshi ABE, Masaaki KIMURA, Takeshi TSUCHIDA, Katsumi NODA, Sadao NAKANE, Michitada SASAJIMA, Masahiro OHZEKI
Publikováno v:
The Journal of Toxicological Sciences. 6:47-66
Publikováno v:
Folia Pharmacologica Japonica. 71:61-69
Rat mesenteric and hind limb arteries were perfused with the rat's own blood under constant perfusion rate, in situ. The effect of dopamine (DA) administered intraarterially was investigated and compared with effects of norepinephrine (NE), tyramine
Autor:
Yasuo TARUMOTO, Masaaki KIMURA, Hiroshi TOKADO, Reiko SHINOZAWA, Takeshi TSUCHIDA, Katsumi NODA, Sadao NAKANE, Michitada SASAJIMA, Masahiro OHZEKI
Publikováno v:
The Journal of Toxicological Sciences. 6:97-120
Autor:
Michitada SASAJIMA, Yasuo TARUMOTO, Hironaka AIHARA, Yoshiharu TANAKA, Shuji SAITO, Takashi SAKAGAWA, Yukiko TOKUNAGA, Eikichi HOSOYA
Publikováno v:
Folia Pharmacologica Japonica. 73:465-477
Physical dependence liability of chlorphenesin carbamate (CPC) was studied in parallel with phenobarbital-Na (PB). Beagle dogs were used and the overall duration of the experiment was 85 days, i.e. the first dosing period was 42 dyas (6 weeks) in whi
Publikováno v:
Japanese Journal of Pharmacology. 30:29-36
Studies were carried out to elucidate the mechanism of action of chlorphenesin carbamate (CPC) and to compare the effect of the drug with that of mephenesin on the isolated bullfrog spinal cord. Ventral and dorsal root potentials were recorded by mea
Autor:
Akira Kasai, Michitada Sasajima, Takeshi Tsuchida, Sadao Nakane, Hiroshi Tokado, Katsumi Noda, Yuko Iwamatsu, Masahiro Ohzeki, Yasuo Tarumoto, Masaaki Kimura
Publikováno v:
The Journal of Toxicological Sciences. 6:121-140
The percutaneous subacute toxicity of 0.1% and 0.5% hydrocortisone 17-butyrate 21-propionate ointment (0.1% HBP, 0.5% HBP) were studied in beagle dogs for 3 months at the daily dose level of 200 mg per kilogram of body weight, using 0.1% and 0.5% hyd
Autor:
Michitada Sasajima, Yasuo Tarumoto, Yoshifumi Tsutsui, Satoshi Abe, Masahiro Ohzeki, Sadao Nakane
Publikováno v:
The Journal of Toxicological Sciences. 6:1-16
The acute toxicity of hydrocortisone 17-butyrate 21-propionate (HBP), hydrocortisone 17-butyrate (HB17) and hydrocortisone 21-butyrate (HB21) were investigated by three administration routes (s.c., i.p. and p.o.) in mice, rats and dogs. In the case o
Autor:
Michitada Sasajima, Ryuichi Saziki, Ichiro Tanaka, Sadao Nakane, Katsuo Hatayama, Hideo Saotome, Kazuaki Kyogoku
Publikováno v:
Folia Pharmacologica Japonica. 74:897-905
A series of extracted fractions from sophora subprostrata was screened by determining anti-ulcer effects in pylorus ligated and stressed rats. Fr. [C-2] had the most potent anti-ulcer effects of all fractions extracted. Sophoradin and sophoranone whi
Autor:
Sadao Nakane, Masahiro Ohzeki, Yasuo Tarumoto, Yoshifumi Tsutsui, Takashi Ohshima, Takashi Sakagawa, Michitada Sasajima, Satoshi Abe
Publikováno v:
The Journal of Toxicological Sciences. 6:141-157
The visual toxicity and the ototoxicity of hydrocortisone 17-butyrate 21-propionate (HBP), a newly synthesized anti-inflammatory steroid, was investigated using rats and dogs. (1) Electroretinogram (ERG) and visually evoked potential (VEP) in rats we