Výsledky vyhledávání - "Michita Suenobu"

Cooperative Therapeutic Action of Retinoic Acid Receptor and Retinoid X Receptor Agonists in a Mouse Model of Alzheimer's Disease

Autor: Kohichi Kawahara, Yukihiko Sugimoto, Hiroshi Fukasawa, Michita Suenobu, Madoka Nakagomi, Akihiko Kuniyasu, Hideyuki Ohtsuka, Koichi Shudo, Hitoshi Nakayama

Publikováno v: Journal of Alzheimer's Disease. 42:587-605

Alzheimer's disease (AD) is a neurodegenerative process involving amyloid-β (Aβ) peptide deposition, neuroinflammation, and progressive memory loss. Here, we evaluated whether oral administration of retinoic acid receptor (RAR)α,β agonist Am80 (t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cab1e60830ddcbd6dde34674eefd33
https://doi.org/10.3233/jad-132720

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Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice

Autor: Michita Suenobu, Kiyohiro Koga, Akira Yoshida, Atsushi Hyodo, Nobuaki Tamamaki, Yukihiko Sugimoto, Hitoshi Nakayama, Koichi Kawahara, Hideyuki Ohtsuka, Akihiko Kuniyasu

Publikováno v: Neuroscience. 207

We previously reported that the anti-inflammatory cytokine interleukin (IL)-4 induced selective clearance of oligomeric β-amyloid (Aβ(1-42)) in rat primary type 2 microglial cells. For the present study, we investigated whether IL-4 and IL-13 could

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a63c4aaa9e9587fd92c405a29e44df
https://pubmed.ncbi.nlm.nih.gov/22342341

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Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice

Autor: Kenichiro Nagatomo, Hitoshi Nakayama, Hideyuki Ohtsuka, Kohichi Kawahara, Akira Maeda, Kentaro Nishi, Akihiko Kuniyasu, Matthias Staufenbiel, Madoka Nakagomi, Koichi Shudo, Michita Suenobu

Publikováno v: Biologicalpharmaceutical bulletin. 32(7)

The purpose of this study is to investigate whether a synthetic retinoid Am80 (tamibarotene) exhibits any improving effects on amyloid precursor protein (APP)23 mice, a model of Alzheimer's disease. Am80 was orally administered in feed to 20-week (5-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98daf6b24860d8e06e0aa897cc7cfcf9
https://pubmed.ncbi.nlm.nih.gov/19571405

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