Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michishige Noguchi"'
Autor:
Michishige Noguchi, Yoshiaki Kawai
Publikováno v:
The Journal of Toxicological Sciences. 21:113-123
The mechanism of prolongation of sleeping (anesthesia) time after phenobarbital (PB) treatment was assessed in mice with ethionine (ET)-induced liver disorders (ET-treated group). The brain gamma-aminobutyric acid (GABA), glutamic acid (GLU), lactic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e041ca01a04a91f6ea385f834f6d7a
https://doi.org/10.2131/jts.21.2_113
https://doi.org/10.2131/jts.21.2_113
Autor:
Takaaki Yamamura, Hiroshi Kuse, Yoshiaki Kawai, Naoki Hishida, Michishige Noguchi, Masaki Hori
Publikováno v:
The Journal of toxicological sciences. 22
The acute toxicity studies of taltirelin tetrahydrate (TA-0910), a new thyrotropin-releasing hormone (TRH) analogue, were performed in Slc:ddY mice, Slc:Wistar rats and beagle dogs of both sexes. The drug was administered to mice and rats by oral(p.o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cad03ef6fb43659db330d14e7b50a8f
https://pubmed.ncbi.nlm.nih.gov/9430092
https://pubmed.ncbi.nlm.nih.gov/9430092
Publikováno v:
Experimental animals. 45(2)
In experiment 1, the amount of aniline (AN) metabolites in the primary cell culture medium of the liver cells obtained from ethionine (ET)-treated rats was compared with that of the control (normal) rats. Although the metabolites detected in both gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d31efc6d0d1f43a595ef31f24f60b77
https://pubmed.ncbi.nlm.nih.gov/8726141
https://pubmed.ncbi.nlm.nih.gov/8726141
Publikováno v:
The Journal of toxicological sciences. 19(4)
Phenobarbital (PB) was orally administered once at a dose of 100 mg/kg to the liver injury model rats treated with DL-ethionine (ET), and the effects of PB on the liver drug metabolizing enzymes (DME) were chiefly examined. Liver weight, liver micros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3852f3153c315bfdede9a24c3f2a2b7e
https://pubmed.ncbi.nlm.nih.gov/7884831
https://pubmed.ncbi.nlm.nih.gov/7884831
Publikováno v:
The Journal of toxicological sciences. 18(4)
The toxicokinetic parameters of phenobarbital (PB) were assessed in a female rat model of liver disease. In a preliminary study to determine the optimum dose of DL-ethionine (ET) for creating liver damage, intraperitoneal injection of 250, 500, or 1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d2a21083c2e44f6757ded9f006cc40
https://pubmed.ncbi.nlm.nih.gov/8295228
https://pubmed.ncbi.nlm.nih.gov/8295228
Autor:
Yoshiaki Kawai, Kaichiro Ishibashi, Michishige Noguchi, Kiyoshi Miyai, Osamu Tanizawa, Yuichi Kumahara, Toshihide Yamamoto, Mizuo Azukizawa
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 42:254-259
Pituitary-thyroid function was assessed in 12 patients with trophoblastic disease (4 hydatidiform mole, 3 invasive mole, and 5 choriocarcinoma). Thyroid-stimulating activity was detectable, by means of the McKenzie bioassay, in 6 patients (Group 1) b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e98af3a85db281bd14f74b7716d375b
https://doi.org/10.1210/jcem-42-2-254
https://doi.org/10.1210/jcem-42-2-254
Publikováno v:
Jikken dobutsu. Experimental animals. 38(3)
For establishing the optimal incubation time (OIT) for measurement of the activated partial thromboplastin time (APTT) in dogs, rabbits, guinea pigs, rats and mice, we determined the shortest clotting time of the plasma from each animal species and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8906c92f5be849cdb5c531cdf34ce48a
https://pubmed.ncbi.nlm.nih.gov/2792204
https://pubmed.ncbi.nlm.nih.gov/2792204
Publikováno v:
Jikken dobutsu. Experimental animals. 36(4)
Prolonged prothrombin time in the blood coagulation test was seen in some beagle dogs whose activated partial prothrombin times were distributed within the normal range. This phenomenon suggested possible abnormalities in coagulation factors II, V, V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a81ed61dfe78746561f4095498eb4e7
https://pubmed.ncbi.nlm.nih.gov/3436375
https://pubmed.ncbi.nlm.nih.gov/3436375