Zobrazeno 1 - 10
of 308
pro vyhledávání: '"Michio Ui"'
Publikováno v:
Antioxidants, Vol 10, Iss 9, p 1398 (2021)
Lung fibrosis is the primary pathology in idiopathic pulmonary fibrosis and is considered to result from an increase in reactive oxygen species (ROS) levels in alveolar epithelial cells. However, the exact mechanism underlying lung fibrosis remains u
Externí odkaz:
https://doaj.org/article/5549e55c491b444fbc1da67da170be0a
Autor:
Young-Jin Im, Dong-Soon Im, Yun-Kyung Lee, Eun-Hee Lee, Koichi Sato, Hideaki Tomura, Toshiaki Katada, Michio Ui, Fumikazu Okajima
Publikováno v:
Journal of Pharmacological Sciences, Vol 97, Iss 3, Pp 443-446 (2005)
Sphingosine-1-phosphate (S1P) acts on a set of G protein-coupled receptors in the plasma membrane and also as a second messenger in certain cell types. There are two possible pathways to mobilize intracellular Ca2+ concentration by S1P. One is throug
Externí odkaz:
https://doaj.org/article/3329e06e16ac46939b3cabb1f09fc791
Autor:
Koichi Itaya, Michio Ui
Publikováno v:
Journal of Lipid Research, Vol 6, Iss 1, Pp 16-20 (1965)
Following the introduction by Duncombe of a colorimetric micromethod for the determination of free fatty acids (FFA) dissolved in chloroform, we studied the optimum conditions for chloroform extraction of FFA from blood or other biological fluids. A
Externí odkaz:
https://doaj.org/article/1218c062a9f14a0aad688afe69d27c17
Publikováno v:
Life Sciences. 221:284-292
Aims Elucidation of the biological roles of the mitochondrial and cytoplasmic hydroxyl radical (cyto OH) is hampered by the absence of site-specific OH scavengers. Earlier findings using cyto OH scavenger, TA293, indicated that cyto OH causes cellula
Autor:
Tomoko Mineno, Masaaki Ito, Shinichiro Egashira, Takayoshi Okabe, Isao Matsuoka, Kazuo Kumagai, Tetsuo Nagano, Michio Ui, Kazuki Yoshida, Hirotatsu Kojima
Publikováno v:
Life Sciences. 180:137-142
Aims The P2Y 6 nucleotide receptor is widely involved in inflammatory responses, and is a promising molecular target for the treatment of inflammatory diseases. Although several P2Y 6 receptor antagonists have been developed and evaluated thus far, n
Publikováno v:
Biochemical and Biophysical Research Communications. 482:1183-1189
The hydroxyl radical ( OH) possesses the strongest oxidation potential among reactive oxygen species (ROS). Hydroxyl radicals react nonpreferentially with proteins, lipids, and nucleic acids. Additionally, mitochondrial localization of OH causes dysf
Publikováno v:
Inflammation & Cell Signaling. 4
Hydroxyl radicals ( • OH) exhibit the strongest oxidation potential of any reactive oxygen species (ROS) and react non-specifically with cellular components, such as nucleic acids, lipids and proteins. While mitochondrial • OH incites oxidative d
Autor:
Masaaki, Ito, Shin-Ichiro, Egashira, Kazuki, Yoshida, Tomoko, Mineno, Kazuo, Kumagai, Hirotatsu, Kojima, Takayoshi, Okabe, Tetsuo, Nagano, Michio, Ui, Isao, Matsuoka
Publikováno v:
Life sciences. 180
The P2YHigh-throughput screening (HTS) was used to study the effects of various compounds on human P2YAmong structurally diverse chemical libraries totalling 141,700 compounds, 43 compounds with an inhibitory activity against the P2YTIM-38 acts as a
Publikováno v:
Cellular Signalling. 17:83-91
Decrease of alpha-adrenergic responses during primary culture of rat hepatocytes was studied. Activation of glycogen phosphorylase by phenylephrine was decreased in the early stage of the culture (within 6 h), however, Ins-P3 production was almost in
Autor:
Kunio Kakegawa, Osamu Izawa, Michio Ui, Eriko Koyama, Akiharu Fujino, Yuji Ohori, Norifumi Sakai, Ken Kitazawa
Publikováno v:
Food and Chemical Toxicology. 41:875-883
Stevia mixture, sweeteners extracted from the leaves of Stevia rebaudiana Bertoni, consists mainly of the glycosides of the diterpene derivative steviol. The aims of this study were to investigate the absorption (in rats) and the hepatic metabolism (