Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michio Tsunoo"'
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 25:419-428
Autor:
Toshiyuki Shimizu, Takuro Niwa, Kei Akimoto, Kaoru Kobayashi, Kan Chiba, Michio Tsunoo, Takuya Yoshimura
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 34(6)
MKC-963, (R)-1-(1-cyclohexylethylamino)-4-phenylphthalazine, a potent inhibitor of platelet aggregation, was synthesized and used in clinical trials in the 1990s. In the process of clinical study, it was found that urinary excretion ratios for 6beta-
Autor:
Akira Mizuchi, Toshiaki Tanaka, Michio Tsunoo, Kazunori Mabuchi, Takeshi Kamioka, Masaharu Hosaka, Yukio Shimazaki, Yoshihide Hashimoto
Publikováno v:
The Journal of clinical endocrinology and metabolism. 85(2)
The physiological and pharmacological functions of the 20-kDa human GH (20K-hGH) isoform are unknown. We conducted a pharmacokinetic study of recombinant 20K-hGH in human subjects (Phase I clinical trial). Placebo or 20K-hGH was administered sc to no
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 13:273-283
Autor:
Michio Tsunoo
Publikováno v:
Juntendo Medical Journal. 21:323-328
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 17:541-550
Publikováno v:
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics. 20:735-740
The pharmacokinetic disposition of Cepharanthin, a biscoclaurine alkaloid, was investigatedin healthy subjects following single oral doses of 10, 30, 60, and 120mg. For 30, 60, and 120mg, 5 subjects were studied for each dose ; for 10 mg, only 2 subj
Autor:
Henry B. Perlman, Michio Tsunoo
Publikováno v:
Acta Oto-Laryngologica. 59:437-450
In the normal animal, administration of 100% oxygen, 8% CO2 or I.V. epinephrine produced increases in perilymph oxygen tension. This value was highest for pure oxygen. Only CO2 or I.V. epinephrine increased strial blood flow rate and though similar i
Autor:
Michio Tsunoo, H. B. Perlman
Publikováno v:
Acta Oto-Laryngologica. 67:460-466
The principal source of oxygen to the cochlea is the arterial blood supply. When blood flow (oxygen delivery) is stopped the reserves of oxygen in the cochlea are very limited and begin to fall in a few seconds. The oxygen reserves drop in a linear f
Autor:
Michio Tsunoo
Publikováno v:
Folia Pharmacologica Japonica. 55:430-437