Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Michio M. Kawano"'
Publikováno v:
European Journal of Haematology. 84:137-144
Interleukin-6 (IL-6) is an important growth factor for myeloma cells. IL-6 promotes the survival and proliferation of multiple myeloma (MM) cells through the phosphorylated proteins, including STAT3, MAPK, and Akt. Chemical components that suppress t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e179cc02a55041e50357739f13f6d3
https://doi.org/10.1111/j.1600-0609.2009.01365.x
https://doi.org/10.1111/j.1600-0609.2009.01365.x
Autor:
Maged S. Mahmoud, Michio M. Kawano, Mohd S. Iqbal, Ken-ichiro Otsuyama, Toshikazu Gondo, Hideki Asaoku, Karim Shamsasenjan
Publikováno v:
European Journal of Haematology. 83:302-312
To evaluate nuclear factor-kappaB (NF-kappaB) activity in primary myeloma cells from myeloma patients, we confirmed that the expression levels of CD54 showed a good correlation with the levels of DNA binding activity for NF-kappaB in human myeloma ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f21c4a21b3a5c8d231b51ef6443f05
https://doi.org/10.1111/j.1600-0609.2009.01284.x
https://doi.org/10.1111/j.1600-0609.2009.01284.x
Autor:
Maged S. Mahmoud, Michio M. Kawano, Ken-ichiro Otsuyama, Saeid Abroun, Karim Shamsasenjan, Mohd S. Iqbal, Hideki Asaoku
Publikováno v:
International Journal of Hematology. 89:310-318
Human myeloma cells from about 10% of cases with multiple myeloma expressed CD33 and had monocytoid morphology with convoluted nuclei, and all these patients had no increase in serum CRP values. In CD33(+) myeloma cells as well as myeloma cell lines,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495f37433b8b41b0b9a6438388a4d8e5
https://doi.org/10.1007/s12185-009-0256-y
https://doi.org/10.1007/s12185-009-0256-y
Publikováno v:
Journal of Clinical and Experimental Hematopathology. 46:55-66
Cytokines exert multiple biological functions through binding to their specific receptors that triggers activation of intracellular signaling cascades. The cytokine-mediated signals may produce variable and even opposing effects on different cell typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf2077e463c91f6e436554eec03c867
https://doi.org/10.3960/jslrt.46.55
https://doi.org/10.3960/jslrt.46.55
Autor:
Saeid Abroun, Michio M. Kawano, Shangqin Liu, Xu Zheng, Ken-ichiro Otsuyama, Koji Miyamoto, Zi Ma, Yasuko Maki, Hideaki Ishikawa, Masanori Obata, Fu-Jun Li, Naohiro Tsuyama
Publikováno v:
Blood. 105:3312-3318
In the search for a more effective adjuvant therapy to treat multiple myeloma (MM), we investigated the effects of the traditional Chinese herbal medicines Huang-Lian-Jie-Du-Tang (HLJDT), Gui-Zhi-Fu-Ling-Wan (GZFLW), and Huang-Lian-Tang (HLT) on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78fdff5671766ba2a87f0945606bef92
https://doi.org/10.1182/blood-2004-10-3915
https://doi.org/10.1182/blood-2004-10-3915
Autor:
Shangqin Liu, Masanori Obata, Xu Zheng, Ken-ichiro Otsuyama, Fu-Jun Li, Saeid Abroun, Naohiro Tsuyama, Michio M. Kawano, Hideaki Ishikawa
Publikováno v:
Blood. 103:2291-2298
Interleukin-6 (IL-6) is a growth and antiapoptotic factor for human myeloma cells. The autocrine loop and increased expression of the growth factor receptors have been postulated as the mechanisms of tumorigenesis. Here we show that IL-6 stimulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c213bb562910e692d7437db2e9ceb1c
https://doi.org/10.1182/blood-2003-07-2187
https://doi.org/10.1182/blood-2003-07-2187
Autor:
Fu-Jun Li, Michio M. Kawano, Hideaki Ishikawa, Shangqin Liu, Xu Zheng, Saeid Abroun, Naohiro Tsuyama, Ken-ichiro Otsuyama
Publikováno v:
Leukemia & Lymphoma. 44:1477-1481
Multiple myeloma (MM) is a proliferative disorder of monoclonal plasma cells which accumulate in human bone marrow, and myeloma cells proliferate in response to a cytokine, interleukin-6 (IL-6). We recently found that MPC-1- CD49e- immature myeloma c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8355b2d4f723bc82bfeddb2bdc6e81
https://doi.org/10.3109/10428190309178767
https://doi.org/10.3109/10428190309178767
Autor:
Hideaki Ishikawa, Ryuichi Fujii, Naohiro Tsuyama, Michio M. Kawano, Maged S. Mahmoud, Shangqin Liu, Saeid Abroun, Fu-Jun Li
Publikováno v:
Leukemia & Lymphoma. 43:613-616
Multiple myeloma (MM) is a proliferative disorder of monoclonal plasma cells which accumulate in human bone marrow (BM). CD19 is a hallmark differentiation antigen of the B cell lineage and positively regulates antigen receptor signal transduction in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21f23698b6c4995d4adb8aa57e7ae1a
https://doi.org/10.1080/10428190290012146
https://doi.org/10.1080/10428190290012146
Autor:
Michio M. Kawano, Hideaki Ishikawa, Xu Zheng, Saeid Abroun, Fu-Jun Li, Shangqin Liu, Naohiro Tsuyama, Ken-ichiro Otsuyama
Publikováno v:
International Journal of Hematology. 76:329-333
Human myeloma cells are heterogenous morphologically and phenotypically. Myeloma cells can be classified into at least 5 subpopulations; MPC-1-CD45+CD49e-, MPC-1-CD45-CD49e- immature myeloma cells, MPC-1+CD45-CD49e-, MPC-1+CD45+CD49e- intermediate my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bed70a94ac8fefe3cffc12bddc89d5
https://doi.org/10.1007/bf03165278
https://doi.org/10.1007/bf03165278
Publikováno v:
Leukemia & Lymphoma. 39:51-55
Multiple myeloma (MM) is a hematologic malignancy of human plasma cells, and myeloma cells can be classified into several subpopulations according to phenotypic differences, such as CD38 MPC-1- CD49e- immature, CD38 MPC-1+ CD49e- intermediate and CD3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf41904cb236336505ed41eca8c9dcb3
https://doi.org/10.3109/10428190009053538
https://doi.org/10.3109/10428190009053538