Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Michio Kurosu"'
Publikováno v:
MethodsX, Vol 10, Iss , Pp 102095- (2023)
The tunicamycins are important biochemical tools to study N-linked glycosylation and protein misfolding in cancer biochemistry fields. We reported a convergent synthesis of tunicamycin V with 21% overall yield from D-galactal. We have further optimiz
Externí odkaz:
https://doaj.org/article/59c6abea0f0646ceb4a360c9f21c9af8
Autor:
Katsuhiko Mitachi, Shou M. Kurosu, Cody D. Gillman, Hyun Gi Yun, William M. Clemons, Jr., Michio Kurosu
Publikováno v:
MethodsX, Vol 6, Iss , Pp 2305-2321 (2019)
Immunotherapy that targets N-linked glycans has not yet been developed due in large part to the lack of specificity of N-linked glycans between normal and malignant cells. N-Glycan chains are synthesized by the sequential action of glycosyl transfera
Externí odkaz:
https://doaj.org/article/95996a3fb5d54e9590df403a305b6ff0
Autor:
Michio Kurosu, Katsuhiko Mitachi, Junshu Yang, Edward V. Pershing, Bruce D. Horowitz, Eric A. Wachter, John W. Lacey, Yinduo Ji, Dominic J. Rodrigues
Publikováno v:
Molecules, Vol 27, Iss 1, p 322 (2022)
Rose bengal has been used in the diagnosis of ophthalmic disorders and liver function, and has been studied for the treatment of solid tumor cancers. To date, the antibacterial activity of rose bengal has been sporadically reported; however, these da
Externí odkaz:
https://doaj.org/article/d15cb199ea8c47d6b6598f99a85cbffb
Autor:
Katsuhiko Mitachi, Hyun Gi Yun, Sara M. Kurosu, Shakiba Eslamimehr, Maddie R. Lemieux, Lada Klaić, William M. Clemons, Michio Kurosu
Publikováno v:
ACS Omega, Vol 3, Iss 2, Pp 1726-1739 (2018)
Externí odkaz:
https://doaj.org/article/7f888f0e3c984d9c8fc374c766595958
Autor:
Michio Kurosu, Katsuhiko Mitachi, Edward V. Pershing, Bruce D. Horowitz, Eric A. Wachter, John W. Lacey, Yinduo Ji, Dominic J. Rodrigues
Publikováno v:
The Journal of Antibiotics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84b6c4da3918d43138475b32ab6c76a6
https://doi.org/10.1038/s41429-023-00622-1
https://doi.org/10.1038/s41429-023-00622-1
Autor:
Pratap Chandra Acharya, Michio Kurosu
Publikováno v:
Medicinal Chemistry of Chemotherapeutic Agents ISBN: 9780323905756
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35b52fa39cdba8f455a27cbeeff39856
https://doi.org/10.1016/b978-0-323-90575-6.00014-4
https://doi.org/10.1016/b978-0-323-90575-6.00014-4
A Convenient Protecting Group for Uridine Ureido Nitrogen: (4,4′-Bisfluorophenyl)methoxymethyl Group
Publikováno v:
Synthesis (Stuttg)
(4,4′-Bisfluorophenyl)methoxymethyl (BFPM) group of uridine ureido nitrogen shows good relative stability in a variety of chemical transformation reactions for uridine. The BFPM group can be cleaved by 2% of TFA in CH2Cl2 without affecting the Boc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715df8e2938bfc1d1e58a431b1ab78db
https://doi.org/10.1055/a-1464-2473
https://doi.org/10.1055/a-1464-2473
Autor:
Marcus A. Alvarez, Lorraine M. Albritton, David Shibata, Ajeeth K. Pingili, Jeremiah L. Deneve, Rita Kansal, D. Neil Hayes, Evan S. Glazer, S. Mazher Hussain, Danny Yakoub, Gustavo A. Miranda-Carboni, Leah E. Hendrick, Michio Kurosu, TJ Hollingsworth, Paxton V. Dickson, Liza Makowski, Abul Elahi
Publikováno v:
Cellular Oncology. 44:673-687
The transforming growth factor-beta (TGF-β) pathway plays a paradoxical, context-dependent role in pancreatic ductal adenocarcinoma (PDAC): a tumor-suppressive role in non-metastatic PDAC and a tumor-promotive role in metastatic PDAC. We hypothesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e119ce96854bdf1ec19ef3ae0a06423
https://doi.org/10.1007/s13402-021-00594-0
https://doi.org/10.1007/s13402-021-00594-0
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
ABSTRACTThe conventional method for quantitating Mycobacterium tuberculosis (Mtb) in vitro and in vivo relies on bacterial colony forming unit (CFU) enumeration on agar plates. Due to the slow growth rate of Mtb, it takes 3-6 weeks to observe visible
Externí odkaz:
https://doaj.org/article/beebf1237e3749859ec5188c495fbfe8
Autor:
Katsuhiko Mitachi, David Mingle, Wendy Effah, Antonio Sánchez‐Ruiz, Kirk E. Hevener, Ramesh Narayanan, William M. Clemons, Francisco Sarabia, Michio Kurosu
Publikováno v:
Angewandte Chemie (International ed. in English). 61(31)
A short total synthesis of tunicamycin V (1), a non-selective phosphotransferase inhibitor, is achieved via a Büchner–Curtius–Schlotterbeck type reaction. Tunicamycin V can be synthesized in 15 chemical steps from D-galactal with 21 % overall yi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c425a9fb61d5fac4afb138e48f990c90
https://pubmed.ncbi.nlm.nih.gov/35594368
https://pubmed.ncbi.nlm.nih.gov/35594368