Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michinori Takashina"'
Autor:
Hiroki Yokoo, Seiichi Chiba, Kengo Tomita, Michinori Takashina, Hiroshi Sagara, Saburo Yagisita, Yasuo Takano, Yuichi Hattori
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51539 (2012)
Sepsis is a major clinical challenge and septic encephalopathy is its nasty complication. The pathogenesis and underlying mechanisms of septic encephalopathy are not well understood. This study sought to fully characterize sepsis-associated biochemic
Externí odkaz:
https://doaj.org/article/9521003cc2b246558c25f8cdfe7234c2
Autor:
Wakana Ohashi, Kengo Tomita, Yuichi Hattori, Tokiko Suzuki, Kei Tomihara, Michinori Takashina, Makoto Noguchi, Sayaka Inoue, Qing-Li Zhao, Kohshi Hattori
Publikováno v:
International Journal of Oncology. 50:787-797
The effect of resveratrol on various human cancer cells was investigated with special focus on apoptotic cell death, in an attempt to further characterize its mechanism of action. There were great differences in the anti-viability effect of resveratr
Autor:
Qiang Wang, Wakana Ohashi, Lobna A. Abedelzaher, Kohshi Hattori, Hiroki Yokoo, Michinori Takashina, Kimimasa Sakata, Yuichi Hattori, Takahiro Imaizumi, Takuya Sakamoto, Naoyuki Matsuda
Publikováno v:
Critical Care Medicine. 43:e508-e520
Objectives:The calcium sensitizer levosimendan is used in treatment of decompensated heart failure and may also exhibit anti-inflammatory properties. We examined whether treatment with levosimendan is substantially beneficial in mice with cecal ligat
Autor:
Mariko Takebe, Kumiko Taguchi, Hirofumi Oishi, Yasuo Takano, Kengo Tomita, Mitsuaki Yamazaki, Yuta Aoki, Hiroki Yokoo, Michinori Takashina, Yuichi Hattori
Publikováno v:
Journal of Surgical Research. 187:559-570
Background Epigenetic programming, dynamically regulated by histone acetylation, may play a key role in the pathophysiology of sepsis. We examined whether histone deacetylase (HDAC) can contribute to sepsis-associated inflammation and apoptosis. Mate
Autor:
Tokiko Suzuki, Lobna A. Abdelzaher, Kengo Tomita, Michinori Takashina, Yuichi Hattori, Takahiro Imaizumi
Publikováno v:
Life sciences. 150
Glycemic fluctuations may play a critical role in the pathogenesis of diabetic complications, such as cardiovascular disease. We investigated whether the oxycarotenoid astaxanthin can reduce the detrimental effects of fluctuating glucose on vascular
Autor:
Hiroki Yokoo, Michinori Takashina, Kengo Tomita, Yuichi Hattori, Naoyuki Matsuda, Seiji Yamamoto, Yasuo Takano, Ken-ichi Takano
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 336:381-390
There is growing evidence that the HMG-CoA reductase inhibitors (statins) provide some of the beneficial effects that are independent of their lipid-lowering effects. Recent animal experiments and clinical trials suggest that statin use may limit the
Publikováno v:
European journal of pharmacology. 761
Direct antitumor effects of bisphosphonates (BPs) have been demonstrated in various cancer cells in vitro. However, the effective concentrations of BPs are typically much higher than their clinically relevant concentrations. Oral cancers frequently i
Autor:
Kenta Kambara, Shiho Fujisaka, Ryuji Hayashi, Michinori Takashina, Yuichi Hattori, Wakana Ohashi, Kengo Tomita, Hisashi Mori, Kazuyuki Tobe
Publikováno v:
The American journal of pathology. 185(1)
Although phenotypically polarized macrophages are now generally classified into two major subtypes termed proinflammatory M1 and anti-inflammatory M2 macrophages, a contributory role of lung M2 macrophages in the pathophysiological features of acute
Autor:
MICHINORI TAKASHINA, SAYAKA INOUE, KEI TOMIHARA, KENGO TOMITA, KOHSHI HATTORI, QING-LI ZHAO, TOKIKO SUZUKI, MAKOTO NOGUCHI, WAKANA OHASHI, YUICHI HATTORI
Publikováno v:
International Journal of Oncology; Mar2017, Vol. 50 Issue 3, p787-797, 11p
Autor:
Yasuo Takano, Kengo Tomita, Seiichi Chiba, Saburo Yagisita, Hiroki Yokoo, Michinori Takashina, Hiroshi Sagara, Yuichi Hattori
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 12, p e51539 (2012)
PLoS ONE, Vol 7, Iss 12, p e51539 (2012)
Sepsis is a major clinical challenge and septic encephalopathy is its nasty complication. The pathogenesis and underlying mechanisms of septic encephalopathy are not well understood. This study sought to fully characterize sepsis-associated biochemic