Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Michinori, Koebis"'
Autor:
Shusaku Masuda, Nobuhiro Kurabayashi, Rina Nunokawa, Yuta Otobe, Hiroko Kozuka-Hata, Masaaki Oyama, Yuri Shibata, Jun-ichiro Inoue, Michinori Koebis, Atsu Aiba, Hikari Yoshitane, Yoshitaka Fukada
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract D-site binding protein, DBP, is a clock-controlled transcription factor and drives daily rhythms of physiological processes through the regulation of an array of genes harboring a DNA binding motif, D-box. DBP protein levels show a circadian
Externí odkaz:
https://doaj.org/article/3574c164cb024bae8b4f8b6fee3b8bb9
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Insomnia is highly comorbid in patients with psychiatric disorders, including depression, bipolar disorder, and substance use disorders, and should be treated as an independent condition. Dual orexin receptor antagonists (DORAs) have been in
Externí odkaz:
https://doaj.org/article/ab8a3f457ec3400ea66278dd7ff36b2a
Autor:
Natsuki Tagawa, Keita Mori, Michinori Koebis, Atsu Aiba, Yuichi Iino, Yousuke Tsuneoka, Hiromasa Funato
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Nest-building behavior is a widely observed innate behavior. A nest provides animals with a secure environment for parenting, sleep, feeding, reproduction, and temperature maintenance. Since animal infants spend their time in a nest, nest-bu
Externí odkaz:
https://doaj.org/article/1498bbe78c89454e84c1561b481408bf
Autor:
Wataru Sako, Yuki Kogo, Michinori Koebis, Yoshiaki Kita, Hajime Yamakage, Takayuki Ishida, Nobutaka Hattori
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract It remains unclear which adjunctive drug for Parkinson’s disease (PD) in combination with levodopa is more effective, tolerable, and safe. We aimed to compare the efficacy, tolerability, and safety among anti-PD drugs from several classes
Externí odkaz:
https://doaj.org/article/dbe5f51eda3749d3adaaa34326d23aaa
Autor:
Yasuko O. Abe, Hikari Yoshitane, Dae Wook Kim, Satoshi Kawakami, Michinori Koebis, Kazuki Nakao, Atsu Aiba, Jae Kyoung Kim, Yoshitaka Fukada
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The mammalian circadian clock is composed of clock genes forming transcriptional feedback loops. Here, the authors identify a key role of the secondary feedback loop that is interlocked with the core loop to establish a perturbation-resilient clock s
Externí odkaz:
https://doaj.org/article/18ffda45dc514cd5946d68f432d3add6
Autor:
Keita Mori, Michinori Koebis, Kazuki Nakao, Shizuka Kobayashi, Yuji Kiyama, Masahiko Watanabe, Toshiya Manabe, Yuichi Iino, Atsu Aiba
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-16 (2022)
Abstract Calsyntenins (CLSTNs) are important synaptic molecules whose molecular functions are not fully understood. Although mutations in calsyntenin (CLSTN) genes have been associated with psychiatric disorders in humans, their function is still unc
Externí odkaz:
https://doaj.org/article/e26329fc52214822b944fac8f46e960e
Autor:
Roongroj Bhidayasiri, Michinori Koebis, Takanori Kamei, Takayuki Ishida, Ippei Suzuki, Jin Whan Cho, Shey-Lin Wu
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Safinamide is a selective, reversible, monoamine oxidase B inhibitor for the treatment of patients with Parkinson's disease (PD) and motor fluctuations. This was a post hoc analysis of the SETTLE study, in which patients with PD and motor fluctuation
Externí odkaz:
https://doaj.org/article/91ff4762aea546c5bdb9644f1cee3f15
Autor:
Taro Kishi, Maika Nishida, Michinori Koebis, Takehiro Taninaga, Kenzo Muramoto, Naoki Kubota, Margaret Moline, Kenji Sakuma, Makoto Okuya, Ikuo Nomura, Nakao Iwata
Publikováno v:
Neuropsychopharmacology Reports, Vol 41, Iss 4, Pp 450-458 (2021)
Abstract Most conventional insomnia medications are gamma‐aminobutylic acid receptor agonists. However, physical dependence is a concern and one of the major limiting factors for long‐term treatment. The dual orexin receptor antagonists, suvorexa
Externí odkaz:
https://doaj.org/article/e1c3cd06cd9f45a8a585f4644d879cd0
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Genetic engineering of non-human primates, which are most closely related to humans, has been expected to generate ideal animal models for human genetic diseases. The common marmoset (Callithrix jacchus) is a non-human primate species adequa
Externí odkaz:
https://doaj.org/article/16bd25af222946dd8e654cb9a9d2af38
Autor:
Yuta Hiraike, Shuichi Tsutsumi, Takahito Wada, Misato Oguchi, Kaede Saito, Masahiro Nakamura, Satoshi Ota, Michinori Koebis, Harumi Nakao, Atsu Aiba, Gaku Nagano, Haruya Ohno, Kenji Oki, Masayasu Yoneda, Takashi Kadowaki, Hiroyuki Aburatani, Hironori Waki, Toshimasa Yamauchi
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104729- (2022)
Summary: Thermogenic brown and beige adipocytes counteract obesity by enhancing energy dissipation via uncoupling protein-1 (Ucp1). However, the effect of genetic variation on these cells, a major source of disease susceptibility, has been less well
Externí odkaz:
https://doaj.org/article/01de9396aecc4b60a77d354c4c154676