Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Michinari, Hirata"'
Autor:
Yoshinori Hayashi, Azumi Ueyama, Soichiro Funaki, Koichi Jinushi, Naoko Higuchi, Hitomi Morihara, Michinari Hirata, Yoji Nagira, Takuro Saito, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Hisashi Wada
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background CCR8-expressing regulatory T cells (Tregs) are selectively localized within tumors and have gained attention as potent suppressors of anti-tumor immunity. This study focused on CCR8+ Tregs and their interaction with CD8+ T cells i
Externí odkaz:
https://doaj.org/article/563e65b4308c413c9805ac940ecc8099
Autor:
Atsushi Kumanogoh, Hisashi Wada, Yoshito Takeda, Mari Tone, Yasushi Shintani, Kota Iwahori, Michinari Hirata, Azumi Ueyama, Akiyoshi Tani, Jun-Ichi Haruta
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 4 (2024)
Background Cancer immunotherapy including immune checkpoint inhibitors is only effective for a limited population of patients with cancer. Therefore, the development of novel cancer immunotherapy is anticipated. In preliminary studies, we demonstrate
Externí odkaz:
https://doaj.org/article/c59908baeae14bb5b96141a34ab1d949
Autor:
Miya Haruna, Azumi Ueyama, Yoko Yamamoto, Michinari Hirata, Kumiko Goto, Hiroshi Yoshida, Naoko Higuchi, Tetsuya Yoshida, Yujiro Kidani, Yamami Nakamura, Morio Nagira, Atsunari Kawashima, Kota Iwahori, Yasushi Shintani, Naganari Ohkura, Hisashi Wada
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Regulatory T cells (Tregs) suppress the host immune response and maintain immune homeostasis. Tregs also promote cancer progression and are involved in resistance to immune checkpoint inhibitor treatments. Recent studies identified selective
Externí odkaz:
https://doaj.org/article/51a74d2b5acc4db8a5531e85252d6b2f
Autor:
Yohei Nose, Takuro Saito, Kei Yamamoto, Kotaro Yamashita, Koji Tanaka, Kazuyoshi Yamamoto, Tomoki Makino, Tsuyoshi Takahashi, Atsunari Kawashima, Miya Haruna, Michinari Hirata, Azumi Ueyama, Kota Iwahori, Taroh Satoh, Yukinori Kurokawa, Hidetoshi Eguchi, Yuichiro Doki, Hisashi Wada
Publikováno v:
Cancer Immunology, Immunotherapy. 72:169-181
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment. Since clinical benefits are limited to a subset of patients, we aimed to identify peripheral blood biomarkers that predict the efficacy of the anti-programmed cell death protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97c421a3ca70079fa191bb62ecf3693
https://doi.org/10.1007/s00262-022-03240-2
https://doi.org/10.1007/s00262-022-03240-2
Autor:
Eisuke Mekada, Hitoo Nakano, Hideo Kanoh, Masahiro Kai, Kenzo Sonoda, Hiroshi Yagi, Yoshihiro Tanaka, Hiroto Mizushima, Hidetoshi Hasuwa, Takuya Kageyama, Ayano Yamazaki, Michinari Hirata, Shingo Miyamoto
Supplementary Figure 1 from Heparin-Binding EGF-Like Growth Factor Is a Promising Target for Ovarian Cancer Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14fff5efeaf9d46299baa47a3dd5ec40
https://doi.org/10.1158/0008-5472.22364052
https://doi.org/10.1158/0008-5472.22364052
Autor:
Eisuke Mekada, Hitoo Nakano, Hideo Kanoh, Masahiro Kai, Kenzo Sonoda, Hiroshi Yagi, Yoshihiro Tanaka, Hiroto Mizushima, Hidetoshi Hasuwa, Takuya Kageyama, Ayano Yamazaki, Michinari Hirata, Shingo Miyamoto
Ovarian cancer is the most frequent cause of cancer death among all gynecologic cancers. We demonstrate here that lysophosphatidic acid (LPA)-induced ectodomain shedding of heparin-binding EGF-like growth factor (HB-EGF) is a critical to tumor format
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282e548f9f4f17a762754d71f00db318
https://doi.org/10.1158/0008-5472.c.6493995
https://doi.org/10.1158/0008-5472.c.6493995
Autor:
Eisuke Mekada, Hitoo Nakano, Hideo Kanoh, Masahiro Kai, Kenzo Sonoda, Hiroshi Yagi, Yoshihiro Tanaka, Hiroto Mizushima, Hidetoshi Hasuwa, Takuya Kageyama, Ayano Yamazaki, Michinari Hirata, Shingo Miyamoto
Supplementary Figure 2 from Heparin-Binding EGF-Like Growth Factor Is a Promising Target for Ovarian Cancer Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f92902f74ab45ee3121946806af3781
https://doi.org/10.1158/0008-5472.22364049
https://doi.org/10.1158/0008-5472.22364049
Autor:
Eisuke Mekada, Hitoo Nakano, Hideo Kanoh, Masahiro Kai, Kenzo Sonoda, Hiroshi Yagi, Yoshihiro Tanaka, Hiroto Mizushima, Hidetoshi Hasuwa, Takuya Kageyama, Ayano Yamazaki, Michinari Hirata, Shingo Miyamoto
Supplementary Legends from Heparin-Binding EGF-Like Growth Factor Is a Promising Target for Ovarian Cancer Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45458951f86f352e472abbd65622bcc5
https://doi.org/10.1158/0008-5472.22364046
https://doi.org/10.1158/0008-5472.22364046
Autor:
Miya Haruna, Atsunari Kawashima, Kei Yamamoto, Shinya Urakawa, Tsunekazu Mizushima, Akiko Morimoto-Okazawa, Makoto Yamasaki, Eiichi Sato, Tomoki Makino, Kota Iwahori, Masaki Mori, Yukinori Kurokawa, Yuichiro Doki, Michinari Hirata, Kumiko Goto, Hisashi Wada
Publikováno v:
Cancer Immunology, Immunotherapy. 70:443-452
It remains unclear whether Helicobacter pylori (H. pylori), a major cause of gastric cancer (GC), is involved in other intestinal cancers. In our previous study, ICOS+ Foxp3+ CD4+ T cells (ICOS+ Tregs) in GC tumors were identified as effector Tregs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9975397fb9ba4c6244713bb57fe4de3a
https://doi.org/10.1007/s00262-020-02696-4
https://doi.org/10.1007/s00262-020-02696-4
Autor:
Ryoichi Imamura, Takayuki Kanazawa, Motohide Uemura, Kentaro Nishida, Tetsuya Yoshida, Takeshi Ujike, Atsunari Kawashima, Yoshiyuki Yamamoto, Shimon Sakaguchi, Satoshi Nojima, Akiko Morimoto-Okazawa, Yujiro Kidani, Norio Nonomura, Koji Hatano, Michinari Hirata, Eiichi Morii, Taigo Kato, Hisashi Wada, Naganari Ohkura, Kota Iwahori, Kazutoshi Fujita, Akira Nagahara
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
It is important to evaluate the clinical importance of both CD8 T cells and CD4 T cells expression simultaneously because they have crucial networks in tumour targeting immune responses. In 97 RCC patients, RNA sequencing and gene set enrichment anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fefbdc2b4ae1323c5ff895d2dcdfad
http://link.springer.com/article/10.1038/s41598-020-63060-1
http://link.springer.com/article/10.1038/s41598-020-63060-1