Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Michinao Mizugaki"'
Autor:
Michinao Mizugaki, Daiki Tsuji, Motohiro Ohshima, Kunihiko Itoh, Kazuyuki Inoue, Hideki Hayashi
Publikováno v:
Protein Engineering Design and Selection. 23:881-888
DNA methylation is involved in many diseases such as cancer and autoimmunity. We generated recombinant single-chain Fv (scFv) antibodies against 5-methyl-2'-deoxycytidine (m(5)dCyd) using phage display technology and a hyperimmunized mouse, and the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829f7c0217fffa80b1792a93e2eefe1c
https://doi.org/10.1093/protein/gzq066
https://doi.org/10.1093/protein/gzq066
Publikováno v:
Drug Metabolism and Disposition. 36:349-352
A novel human cytochrome P450, designated CYP2W1, has recently been identified and is found to be present mainly in tumor cells, particularly in colon cancer cells. In the present study, we report the first systematic investigation of polymorphisms i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7525feccdb49f5f27484da6efbe5836
https://doi.org/10.1124/dmd.107.019141
https://doi.org/10.1124/dmd.107.019141
Publikováno v:
Drug Metabolism and Pharmacokinetics. 22:136-140
We analyzed all nine exons and exon-intron junctions of the CYP2S1 gene in 200 Japanese individuals and identified the following three novel single nucleotide polymorphisms (SNPs): 4612G>A (Glu147Glu) in exon 3, 5478C>T (Leu230Leu) and 5479T>G (Leu23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5988fb85fcb1e59275a0545abb2989
https://doi.org/10.2133/dmpk.22.136
https://doi.org/10.2133/dmpk.22.136
Autor:
Yumiko Konno, Masahiro Hiratsuka, Aiko Ebisawa, Kanako Sakuyama, Yoshihiro Soya, Yoichi Matsubara, Takamitsu Sasaki, Shigeo Kure, Michinao Mizugaki, Akiko Kishiba
Publikováno v:
Journal of Biochemical and Biophysical Methods. 67:87-94
Individualization of drug therapy through genetic testing would maximize the effectiveness of medication and minimize its risks. Recent progress in genetic testing technologies has been remarkable, and they have been applied for the analysis of genet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf80bf711ce6be16c772a33033c9f394
https://doi.org/10.1016/j.jbbm.2006.01.005
https://doi.org/10.1016/j.jbbm.2006.01.005
Autor:
Takanori Hishinuma, Shigeki Kisara, Mika Ozawa, Saki Yoshizawa, Naoto Suzuki, Hiroaki Yamaguchi, Michinao Mizugaki, Junichi Goto, Yoshihisa Tomioka
Publikováno v:
Biological and Pharmaceutical Bulletin. 29:1010-1014
W39F, F52Y, S98G, S98A, and S98C mutants of the neocarzinostatin apoprotein (apo-NCS) were newly prepared and investigated their physicochemical properties. The circular dichroism (CD) spectra of F78W, F52Y, S98A, S98G, S98C were superimposable with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c034afcf7568940f3f71df7367c68b28
https://doi.org/10.1248/bpb.29.1010
https://doi.org/10.1248/bpb.29.1010
Publikováno v:
Drug Metabolism and Pharmacokinetics. 21:332-336
Summary: In this study, the entire coding sequence and the exon-intron junctions of the thiopurine S-methyltransferase (TPMT ) gene from 200 Japanese individuals were screened for mutation. Three novel single nucleotide polymorphisms (SNPs) were iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e263286e972e171be075e695bef83e20
https://doi.org/10.2133/dmpk.21.332
https://doi.org/10.2133/dmpk.21.332
Autor:
Mika, SUGAWARA, Yudai, HINAI, Masahiro, HIRATSUKA, Takamitsu, SASAKI, Yumiko, KONNO, Michinao, MIZUGAKI
Publikováno v:
東北薬科大学研究誌. 52:125-133
The cytochrome P450 enzymes (GYP) play important roles in the metabolism of many therapeutic agents and environmental compounds. Differences in the activities of these enzymes are thought to be responsible for individual variability in drug response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::2be537043ba54e6676c5f33d5721a99a
http://id.nii.ac.jp/1202/00000224/
http://id.nii.ac.jp/1202/00000224/
Publikováno v:
東北薬科大学研究誌. 52:135-140
Human 2, 4-dienoyl-CoA reductase (DECR) is an auxiliary enzyme of β-oxidation, participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered position. DECR gene is approximately 30kb and comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::dded6fdc9b50c493c3af3751269a7ea4
http://id.nii.ac.jp/1202/00000225/
http://id.nii.ac.jp/1202/00000225/
Autor:
Masahiro Hiratsuka, Nanami Koseki, Shuta Ujiie, Mika Sugawara, Michinao Mizugaki, Rina Suzuki, Takamitsu Sasaki, Mutsumi Kudo, Yumiko Konno
Publikováno v:
Drug Metabolism and Pharmacokinetics. 20:387-390
The genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) have been associated with increased toxicity of methotrexate (MTX), a folic acid antagonist that is widely used to treat cancer and immunosuppressive disorders such as rheumatoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1c200c3d43adaa555aec8d3b390a61
https://doi.org/10.2133/dmpk.20.387
https://doi.org/10.2133/dmpk.20.387
Autor:
Junichi Goto, Hiroki Tsukamoto, Masahiro Hiratsuka, Yoshihisa Tomioka, Risa Tayama, Takanori Hishinuma, Naoto Suzuki, Michinao Mizugaki
Publikováno v:
Prostaglandins & Other Lipid Mediators. 73:191-213
Thiazolidinedione, peroxisome proliferator-activated receptor gamma (PPARgamma) agonist, has been used as an anti-diabetic drug and as an useful tool to elucidate multiple PPARgamma functions by in vitro and in vivo studies. We investigated the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39635bedf836e6ffda0247db8fb63bec
https://doi.org/10.1016/j.prostaglandins.2004.01.008
https://doi.org/10.1016/j.prostaglandins.2004.01.008