Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Michimasa Nozaki"'
Autor:
Michimasa Nozaki, Kazuo Nagashima, Kazutoshi Cho, Takamitsu Fujimaki, Yutaka Sawamura, Akiko Ohnishi
Publikováno v:
Child's Nervous System. 22:168-171
Congenital brain tumors, especially tumors diagnosed before birth, are very rare. This report presents a case of a congenital gemistocytic astrocytoma diagnosed by antenatal intrauterine ultrasound. An intrauterine MRI revealed hydrocephalus and a ma
Autor:
Monika E. Hegi, Nicolas de Tribolet, Annie-Claire Diserens, Marie-France Hamou, Michimasa Nozaki, Sophie Godard, Yan Lachat, Hiroyuki Kobayashi
Publikováno v:
Oncogene. 23:6854-6863
Amplification of the epidermal growth factor receptor (EGFR) or expression of its constitutively activated mutant, DeltaEGFR(2-7), in association with the inactivation of the INK4a/Arf gene locus is a frequent alteration in human glioblastoma. The no
Autor:
Michimasa Nozaki, Mitsuhiro Tada, Hiroyuki Kobayashi, Chang-Liang Zhang, Yutaka Sawamura, Hiroshi Abe, Nobuaki Ishii, Erwin G. Van Meir
Publikováno v:
Neuro-Oncology. 1:124-137
Autor:
Izumi Koyanagi, Kenji Mitsumori, Michimasa Nozaki, Satoshi Minoshima, Wakako Shirai, Koichi Kitami, Mitsugi Sakuragi
Publikováno v:
Japanese Journal of Neurosurgery. 8:680-684
Autor:
Yutaka Sawamura, Kazuo Nagashima, Kenzo Takada, Mitsunori Tada, Michimasa Nozaki, Hiroshi Abe, Yuzo Mizugaki
Publikováno v:
Acta Neuropathologica. 95:505-510
We studied overexpression of p53, Bcl-2, Bcl-6, c-Myc and Mdm2 proteins by immunohistochemistry for a total of 27 primary central nervous system B cell lymphomas (CNS lymphomas) in immunocompetent patients and one CNS lymphoma in an AIDS patient. The
Autor:
Richard Iggo, Yutaka Sawamura, Hiroshi Abe, Mitsuhiro Tada, Ryoji Matsumoto, Michimasa Nozaki
Publikováno v:
Acta Neuropathologica. 95:291-296
While it is established that p53 mutation plays a critical role in the carcinogenesis of astrocytic brain tumors, its role remains to be clarified for other types of tumors in the central nervous system (CNS). Using a yeast-based assay which tests th
Autor:
Sophie, Godard, Gad, Getz, Mauro, Delorenzi, Pierre, Farmer, Hiroyuki, Kobayashi, Isabelle, Desbaillets, Michimasa, Nozaki, Annie-Claire, Diserens, Marie-France, Hamou, Pierre-Yves, Dietrich, Luca, Regli, Robert C, Janzer, Philipp, Bucher, Roger, Stupp, Nicolas, de Tribolet, Eytan, Domany, Monika E, Hegi
Publikováno v:
Cancer research. 63(20)
The development of targeted treatment strategies adapted to individual patients requires identification of the different tumor classes according to their biology and prognosis. We focus here on the molecular aspects underlying these differences, in t
Autor:
Vishwas M. Paralkar, Sophie Godard, Michimasa Nozaki, Erwin G. Van Meir, Mirna Tenan, Monika E. Hegi, Marie-France Hamou, Michele Albertoni, Douglas W Fairlie, Nicolas de Tribolet, Samuel N. Breit, Phillip Herbert Shaw
Publikováno v:
Oncogene. 21(27)
Human astrocytic brain tumors select for mutations in the p53 tumor suppressor gene early in malignant progression. p53 is activated upon various kinds of cellular stress leading to apoptosis or cell cycle arrest, but is also implicated in complex bi
Autor:
Monika E. Hegi, Elizabeth W Dell, Michael A. Klein, Robert C. Janzer, W. Seelentag, Annie-Claire Diserens, Daniela Rüedi, Michimasa Nozaki, Adriano Aguzzi
Publikováno v:
Oncogene. 19(47)
p53-germline mutations located in the core DNA-binding domain have been associated with a more dominant tumor penetrance especially for breast cancer and brain tumors. We previously reported an unusual accumulation of CNS tumors associated with a uni
Autor:
Hiroshi Kobayashi, Hiroshi Abe, Mitsuhiro Tada, Michimasa Nozaki, Tetsuya Moriuchi, C L Zhang
Publikováno v:
Oncogene. 19(38)
We have developed a new yeast-based assay for the detection of PTEN nonsense mutation, and applied it to a total of 42 astrocytic tumors. The assay utilizes homologous recombination of PCR-amplified PTEN cDNA samples to a yeast vector which expresses