Výsledky vyhledávání - "Michiko Takakura"

Attitude and perception survey for the Japanese pharmaceutical industry to utilize next-generation sequencing for virus safety assessment of biologics

Autor: Ryutaro HIRASAWA, Michiko TAKAKURA, Takamasa HIRAI, Ken KONO, Yoji SATO

Publikováno v: Translational and Regulatory Sciences. 4:61-67

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c57619dbaf9cf2f6a63291cf1a619118
https://doi.org/10.33611/trs.2022-004

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Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3

Autor: Ryo Tanifuji, Ryutaro Asano, Hiroki Oguri, Kento Koketsu, Michiko Takakura, Hideaki Oikawa, Atsushi Minami

Publikováno v: Journal of the American Chemical Society. 140:10705-10709

The antitumor tetrahydroisoquinoline (THIQ) alkaloids share a common pentacyclic scaffold that is biosynthesized by nonribosomal peptide synthetases involving unique enzymatic Pictet-Spengler cyclizations. Herein we report concise and divergent chemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd55d42b68b0ec961f11d794955eaad5
https://doi.org/10.1021/jacs.8b07161

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Development of cell-based assay for predictively evaluating the FcγR-mediated human immune cell activation by therapeutic monoclonal antibodies

Autor: Michiko Takakura, Akiko Ishii-Watabe, Minoru Tada

Publikováno v: Biochemical and biophysical research communications. 485(1)

Therapeutic monoclonal antibodies (mAbs) have important roles in treatments for various cancers and inflammatory diseases. Their highly target specificities provide controlled safety profiles. However, therapeutic mAbs commonly pose a risk of the ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a90b7b60093a8e2fc833555235adb53
https://pubmed.ncbi.nlm.nih.gov/28196745

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Use of quantitative shotgun proteomics to identify fibronectin 1 as a potential plasma biomarker for clear cell carcinoma of the kidney

Autor: Junichi Matsubara, Kazufumi Honda, Yae Kanai, Masaya Ono, Tomohiro Sakuma, Michiko Takakura, Seiji Naito, Tesshi Yamada, Akira Yokomizo

Publikováno v: Cancer Biomarkers. 10:175-183

Background: Early detection would be one of the most effective means to improve the outcome of renal cell carcinoma (RCC). We searched for a new plasma marker for RCC using a label-free quantitative shotgun proteomics method. Methods: Plasma proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e69373e0c5fe3a2304b47d7aac0233
https://doi.org/10.3233/cbm-2012-0243

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Carbonic anhydrase I as a new plasma biomarker for prostate cancer

Autor: Tomohiro Sakuma, Giman Jung, Michiko Takakura, Yoshinori Tanaka, Masaya Ono, Kenjiro Imada, Seiji Naito, Kazufumi Honda, Masahiro Kamita, Yoshinao Oda, Miho Banno, Michimoto Kobayashi, Akira Yokomizo, Tesshi Yamada

Publikováno v: ISRN Oncology

Serum prostate-specific antigen (PSA) levels ranging from 4 to 10 ng/mL is considered a diagnostic gray zone for detecting prostate cancer because biopsies reveal no evidence of cancer in 75% of these subjects. Our goal was to discover a new highly s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c522452d576fe47213554a942ad776
https://pubmed.ncbi.nlm.nih.gov/23213568

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