Výsledky vyhledávání - "Michiko Narazaki"

Akademický článek

Measurement of technetium-99m sestamibi signals in rats administered a mitochondrial uncoupler and in a rat model of heart failure.

Autor: Akira Kawamoto, Takao Kato, Tetsuo Shioi, Junji Okuda, Tsuneaki Kawashima, Yodo Tamaki, Shinichiro Niizuma, Yohei Tanada, Genzou Takemura, Michiko Narazaki, Tetsuya Matsuda, Takeshi Kimura

Publikováno v: PLoS ONE, Vol 10, Iss 1, p e0117091 (2015)

BACKGROUND:Many methods have been used to assess mitochondrial function. Technetium-99m sestamibi ((99m)Tc-MIBI), a lipophilic cation, is rapidly incorporated into myocardial cells by diffusion and mainly localizes to the mitochondria. The purpose of

Externí odkaz: https://doaj.org/article/92b4a912e0274c07af4eec3bce3bbed2

Zobrazit plný text záznamu

Akademický článek

Differential Neuroprotection by Cyclosporin A and FK506 Following Ischemia Corresponds with Differing Abilities to Inhibit Calcineurin and the Mitochondrial Permeability Transition

Autor: Hiroyuki Uchino, Reiko Minamikawa-Tachino, Tibor Kristián, Guy Perkins, Michiko Narazaki, Bo K. Siesjö, Futoshi Shibasaki

Publikováno v: Neurobiology of Disease, Vol 10, Iss 3, Pp 219-233 (2002)

Transient global or forebrain ischemia leads to severe brain damage following delayed neuronal cell death. We previously reported that cyclosporin A (CsA) provides near total suppression of brain damage in rat forebrain ischemia when allowed to pass

Externí odkaz: https://doaj.org/article/cea9138ac5ac4083aa3bbf6573f347be

Zobrazit plný text záznamu

Akademický článek

Cardiac-specific inhibition of kinase activity in calcium/calmodulin-dependent protein kinase kinase-β leads to accelerated left ventricular remodeling and heart failure after transverse aortic constriction in mice.

Autor: Shin Watanabe, Takahiro Horie, Kazuya Nagao, Yasuhide Kuwabara, Osamu Baba, Hitoo Nishi, Naoya Sowa, Michiko Narazaki, Tetsuya Matsuda, Genzou Takemura, Hiromichi Wada, Koji Hasegawa, Takeshi Kimura, Koh Ono

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e108201 (2014)

The mechanism of cardiac energy production against sustained pressure overload remains to be elucidated.We generated cardiac-specific kinase-dead (kd) calcium/calmodulin-dependent protein kinase kinase-β (CaMKKβ) transgenic (α-MHC CaMKKβkd TG) mi

Externí odkaz: https://doaj.org/article/ecc13d2be7d642a299af22c245b5f04f

Zobrazit plný text záznamu

Akademický článek

Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice.

Autor: Junji Okuda, Shinnichiro Niizuma, Tetsuo Shioi, Takao Kato, Yasutaka Inuzuka, Tsuneaki Kawashima, Yodo Tamaki, Akira Kawamoto, Yohei Tanada, Yoshitaka Iwanaga, Michiko Narazaki, Tetsuya Matsuda, Souichi Adachi, Tomoyoshi Soga, Genzou Takemura, Hiroshi Kondoh, Toru Kita, Takeshi Kimura

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e72173 (2013)

BACKGROUND: Heart failure is associated with changes in cardiac energy metabolism. Glucose metabolism in particular is thought to be important in the pathogenesis of heart failure. We examined the effects of persistent overexpression of phosphoglycer

Externí odkaz: https://doaj.org/article/2fcfa27192c649699058d616c584bc86

Zobrazit plný text záznamu

Quantitative 17O imaging towards oxygen consumption study in tumor bearing mice at 7 T

Autor: Sachiko Koike, Michiko Narazaki, Koichi Ando, Yoko Kanazawa, Hiroo Ikehira

Publikováno v: Magnetic Resonance Imaging. 31(5):643-650

(17)O magnetic resonance imaging (MRI) using a conventional pulse sequence was explored as a method of quantitative imaging towards regional oxygen consumption rate measurement for tumor evaluation in mice. At 7 T, fast imaging with steady state (FIS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fbb5b3a7bcf12e767cc18511d7b961
https://repo.qst.go.jp/records/46570

Zobrazit plný text záznamu

Synthesis and functional evaluation of chiral dendrimer–triamine-coordinated Gd complexes as highly sensitive MRI contrast agents

Autor: Teruyuki Kondo, Syungo Ishikawa, Yu Kimura, Hiroki Miura, Yuka Miyake, Michiko Narazaki, Yasuhiko Tabata, Akio Toshimitsu, Tetsuya Yano, Hiroshi Tsujita, Tetsuya Matsuda

Publikováno v: Tetrahedron Letters. 53:4580-4583

Novel chiral dendrimer–triamine-coordinated Gd complexes were synthesized and shown to have longitudinal relaxivity ( r 1) 3 times higher than that of clinically used Gd-DTPA. The pharmacokinetic differences between optical isomers were estimated f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::baec7de3c4316d20915f6521ba5310b8
https://doi.org/10.1016/j.tetlet.2012.06.072

Zobrazit plný text záznamu

Water-Soluble Fluorinated Polymer Nanoparticle as 19F MRI Contrast Agent Prepared by Living Random Copolymerization from Dendrimer Initiator

Autor: Shinzaburo Ito, Hiroyuki Fujimoto, Michihiro Ogawa, Tetsuya Matsuda, Satoshi Nitahara, Hiroyuki Aoki, Michiko Narazaki, Hiromasa Kataoka

Publikováno v: Bulletin of the Chemical Society of Japan. 85:79-86

Water-soluble fluorinated polymer nanoparticles (PNPs) with well-defined structure were successfully prepared as a 19F MRI contrast agent by living radical copolymerization of 2,2,3,3-tetrafluoropr...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd0a86e01cb239f8b9e021097bf8382f
https://doi.org/10.1246/bcsj.20110048

Zobrazit plný text záznamu

Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice

Autor: Yasutaka Inuzuka, Toru Kita, Akira Kawamoto, Junji Okuda, Souichi Adachi, Yoshitaka Iwanaga, Takao Kato, Shinichiro Niizuma, Tetsuo Shioi, Michiko Narazaki, Yodo Tamaki, Tsuneaki Kawashima, Genzou Takemura, Tetsuya Matsuda, Takeshi Kimura

Publikováno v: Journal of Molecular and Cellular Cardiology. 51:1026-1036

Heart failure is associated with a change in cardiac energy metabolism. SIRT1 is a NAD+-dependent protein deacetylase, and important in the regulation of cellular energy metabolism. To examine the role of SIRT1 in cardiac energy metabolism, we create

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb56cc911f0d9a218861fb94b3ea8689
https://doi.org/10.1016/j.yjmcc.2011.09.013

Zobrazit plný text záznamu

Systematic Study of Protein Detection Mechanism of Self-Assembling 19F NMR/MRI Nanoprobes toward Rational Design and Improved Sensitivity

Autor: Itaru Hamachi, Michiko Narazaki, Kazuya Matsuo, Yousuke Takaoka, Keigo Mizusawa, Tetsuya Matsuda, Keishi Kiminami

Publikováno v: Journal of the American Chemical Society. 133:11725-11731

(19)F NMR/MRI probe is expected to be a powerful tool for selective sensing of biologically active agents owing to its high sensitivity and no background signals in live bodies. We have recently reported a unique supramolecular strategy for specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0215d749fb2fe9ee0b2bd7e253dd8843
https://doi.org/10.1021/ja203996c

Zobrazit plný text záznamu

Synthesis and Evaluation of Water-Soluble Fluorinated Dendritic Block-Copolymer Nanoparticles as a 19F-MRI Contrast Agent

Autor: Satoshi Nitahara, Michihiro Ogawa, Michiko Narazaki, Tetsuya Matsuda, Shinzaburo Ito, Hiroyuki Aoki

Publikováno v: Macromolecular Chemistry and Physics. 211:1602-1609

Well-defined water-soluble fluorinated polymer nanoparticles (PNPs) with a high fluorine content and biocompatibility were successfully prepared by living radical polymerization (LRP) of 2,2,3,3-tetrafluoropropyl methacrylate (TFPMA) from the polyami

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a609cfd2c52c101749efa2cd26f497c
https://doi.org/10.1002/macp.201000100

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání