Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michiko Murakoshi"'
Autor:
Jeff D. Reagan, Hiroaki Maeda, Harumi Kuwabara, Michiko Murakoshi, Miyuki Nagasaki, Futoshi Nara, Yu Mei Xiong
Publikováno v:
Journal of Receptors and Signal Transduction. 37:290-296
GPR142 is a G-protein-coupled receptor (GPCR), whose most potent and efficacious ligand has been reported as being the natural amino acid l-tryptophan. GPR142 is highly expressed in pancreatic β-cells and immune cells, suggesting the receptor may pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f802ddd0163536110761132a4b24f055
https://doi.org/10.1080/10799893.2016.1247861
https://doi.org/10.1080/10799893.2016.1247861
Autor:
Katsuji Kagechika, Michiko Murakoshi, Takahiro Nagayama, Naoki Miyoshi, Aya Isobe, Naohiro Kon
Publikováno v:
Cell Death Discovery
In cardiac myocytes, regulation of mitochondrial Ca2+ is important for cellular signaling and cardiac contraction. Ca2+ entry into the mitochondria is mediated by a highly selective Ca2+ channel called the mitochondrial calcium uniporter, which consi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ffccc53e6a71b31baf109bd5114bdc
https://doi.org/10.1038/cddiscovery.2017.45
https://doi.org/10.1038/cddiscovery.2017.45
Autor:
Julio C. Medina, Yi Chen, Jeff D. Reagan, Masanori Izumi, Ogawa Yasuyuki, Alykhan Motani, Angela Fu, Sarah E. Lively, Ryo Okuyama, Satoshi Shibuya, Mike Lizarzaburu, Michiko Murakoshi, Yong-Jae Kim, Narihiro Toda, Futoshi Nara, Hui Tian, Zice Fu, Peter Fan, Nobuaki Watanabe, Yi-Jyun Lin, Xiaolin Hao, Shauna Lawlis, Qingxiang Liu, Ming Yu, Kozo Oda, Yumei Xiong, Leping Li, Run Zhuang
Publikováno v:
ACS medicinal chemistry letters. 4(8)
GPR142 is a G protein-coupled receptor that is predominantly expressed in pancreatic β-cells. GPR142 agonists stimulate insulin secretion in the presence of high glucose concentration, so that they could be novel insulin secretagogues with reduced o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4260568397b9d04d2d056f0b8d9410bb
https://pubmed.ncbi.nlm.nih.gov/24900747
https://pubmed.ncbi.nlm.nih.gov/24900747
Autor:
Jeff D. Reagan, Julio C. Medina, Xianyun Jiao, Leping Li, Run Zhuang, Mami Yamazaki, Mike Lizarzaburu, Sujen Lai, Jonathan B. Houze, Jiwen Jim Liu, Daniel C.-H. Lin, Alykhan Motani, Ryo Okuyama, Peter Fan, Ying Zhang, Futoshi Nara, Michiko Murakoshi, Angela Fu, Nobuaki Watanabe, Yumei Xiong, Zice Fu, Xiaohui Du, Qingxiang Liu, Ming Yu, Kozo Oda
Publikováno v:
ACS medicinal chemistry letters. 4(9)
Herein, we report the lead optimization of amrinone–phenylalanine based GPR142 agonists. Structure–activity relationship studies led to the discovery of aminopyrazole–phenylalanine carboxylic acid 22, which exhibited good agonistic activity, hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1ab7442e8f424d7e14dca852358e6e
https://pubmed.ncbi.nlm.nih.gov/24900757
https://pubmed.ncbi.nlm.nih.gov/24900757
Autor:
Jeff D. Reagan, Jason Duquette, Ming Yu, Xiaohui Du, Ryo Okuyama, Michiko Murakoshi, Jinqian Liu, Leping Li, Kozo Oda, Jonathan B. Houze, Simon Turcotte, Julio C. Medina, Futoshi Nara, Angela Fu, Mike Lizarzaburu
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(18)
The discovery and initial optimization of a series of phenylalanine based agonists for GPR142 is described. The structure-activity-relationship around the major areas of the molecule was explored to give agonists 90 times more potent than the initial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269595c2647f690b59004e2f7d4a33c7
https://pubmed.ncbi.nlm.nih.gov/22884988
https://pubmed.ncbi.nlm.nih.gov/22884988
Autor:
Zice Fu, Jeff D. Reagan, Kozo Oda, Leping Li, Futoshi Nara, Sujen Lai, Ryo Okuyama, Jonathan B. Houze, Angela Fu, Peter Fan, Yumei Xiong, Simon Turcotte, Mike Lizarzaburu, Ying Zhang, Qingxiang Liu, Xiaohui Du, Wang Shen, Julio C. Medina, Alykhan Motani, Xi Chen, Yong-Jae Kim, Michiko Murakoshi
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(19)
GPR142 is a novel GPCR that is predominantly expressed in pancreatic β-cells. GPR142 agonists potentiate glucose-dependent insulin secretion, and therefore can reduce the risk of hypoglycemia. Optimization of our lead pyridinone-phenylalanine series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2eca1957e8838386b32f37c701beae
https://pubmed.ncbi.nlm.nih.gov/22926069
https://pubmed.ncbi.nlm.nih.gov/22926069
Autor:
Jeff D. Reagan, Jonathan B. Houze, Yumei Xiong, Kozo Oda, Alykhan Motani, Peter Fan, Angela Fu, Leping Li, Ryo Okuyama, Xi Chen, Simon Turcotte, Futoshi Nara, Yong-Jae Kim, Mike Lizarzaburu, Zice Fu, Ying Zhang, Qingxiang Liu, Julio C. Medina, Xiaohui Du, Sujen Lai, Wang Shen, Michiko Murakoshi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:7750
Corrigendum to ‘‘Phenylalanine derivatives as GPR142 agonists for the treatment of Type II diabetes’’ [Bioorg. Med. Chem. Lett. 22 (2012) 6218–6223] Xiaohui Du a,⇑, Yong-Jae Kim , SuJen Lai , Xi Chen , Mike Lizarzaburu , Simon Turcotte ,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c345bd0429cc91aa40f519e086cbbf5
https://doi.org/10.1016/j.bmcl.2012.10.021
https://doi.org/10.1016/j.bmcl.2012.10.021