Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Michiko Miyaki"'
Autor:
Yujiro Nakayama, Takeru Iijima, Rika Wakaume, Keiichi Takahashi, Hiroshi Matsumoto, Daisuke Nakano, Michiko Miyaki, Tatsuro Yamaguchi
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215513 (2019)
BackgroundMicrosatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide units in microsatellites. High-frequency MSI (MSI-H) colorectal cancers (CRCs) are known to have different clinicopathological features compared wi
Externí odkaz:
https://doaj.org/article/ea04ffa9530745999106a120e9bbae57
Autor:
Hiroshi Matsumoto, Takeru Iijima, Rika Wakaume, Tatsuro Yamaguchi, Misato Amaki-Takao, Michiko Miyaki, Soichiro Natsume, Keiichi Takahashi
Publikováno v:
Oncology. 91:162-170
Objective:BRAF D594G mutations in colorectal cancer patients are not clearly understood. We retrospectively investigated the clinicopathological features of colorectal cancers with BRAF D594G mutations. Methods: We selected 908 colorectal cancer pati
Autor:
Misato Takao, Koichi Koizumi, Takeru Iijima, Hiroshi Matsumoto, Rika Wakaume, Keiichi Takahashi, Shinichiro Horiguchi, Tatsuro Yamaguchi, Soichiro Natsume, Michiko Miyaki, Daisuke Nakano
Publikováno v:
Japanese journal of clinical oncology. 48(7)
Background The aim of this study was to clarify clinicopathological features, frequencies of molecular biomarkers, and prognoses in Japanese colorectal cancer patients and compare them with right-sided colon cancer (RCC) and left-sided colorectal can
Autor:
Tatsuro Yamaguchi, Masami Arai, Michiko Miyaki, Koichi Koizumi, Takeru Iijima, Kazuo Tamura, Shinichiro Horiguchi
Publikováno v:
Japanese Journal of Clinical Oncology. 44:1243-1247
The proband was a 32-year-old man with sparse type of familial adenomatous polyposis with fundic gland and duodenal polyps and congenital hypertrophy of the retinal pigment epithelium without osteoma, dental abnormalities and desmoid tumors. Direct D
Autor:
Keiichi Takahashi, Hiroshi Matsumoto, Takeru Iijima, Takeo Mori, Tatsuro Yamaguchi, Michiko Miyaki
Publikováno v:
Oncology. 76:430-434
Objectives: Cdc4 (Fbxw7) is a potential tumor suppressor that regulates ubiquitination and proteolysis of multiple targets such as cyclin E, c-Myc, c-Jun and Notch. CDC4 mutations were investigated in 194 colorectal carcinomas and adenomas for compar
Autor:
Tsunekazu Hishima, Hiroshi Matsumoto, Hidenori Miyamoto, Tatsuro Yamaguchi, Keiichi Takahashi, Michiko Miyaki, Takeo Mori, Takeru Iijima
Publikováno v:
Diseases of the Colon & Rectum. 49:399-406
Role and timing of frameshift mutations during carcinogenesis in hereditary nonpolyposis colorectal cancer have not been examined. This study was designed to clarify the relationship between frameshift mutations and clinicopathologic features in colo
Autor:
Michiko Miyaki, Genevra Guanti, Michael C. Costanza, Hamid Mehenni, Joe-Gahb Park, Nicoletta Resta
Publikováno v:
Gut. 55:984-990
Background and aims: Germline mutations in the LKB1 gene are known to cause Peutz-Jeghers syndrome, which is an autosomal dominant disorder characterised by hamartomatous polyposis and mucocutaneous pigmentation. This syndrome is associated with an i
Autor:
Takeo Mori, Kazuo Tamura, Michiko Miyaki, Joji Utsunomiya, Tatsuro Yamaguchi, Tsunekazu Hishima, Takeru Iijima
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 578:430-433
Germline mutations of the MYH gene have been revealed to associate with the recessive inheritance of multiple colorectal adenomas in Caucasian population. However, MYH mutations in Japanese patients have not yet been clarified. In an assessment of MY
Autor:
Takeo Mori, Michiko Miyaki, Chikashi Nakanishi, Takeru Iijima, Shigehira Saji, Masakazu Toi, Tatsuro Yamaguchi
Publikováno v:
Oncology. 67:476-479
Peutz-Jeghers syndrome (PJS) is an autosomal-dominant polyposis disorder with an increased risk of multiple cancer. The LKB1/STK11 gene, which acts as a tumor suppressor, is responsible for PJS and plays a role in suppressing breast cancer. The low e
Autor:
Toshio Kuroki, Michiko Miyaki
Publikováno v:
Biochemical and Biophysical Research Communications. 306:799-804
The tumor suppressor gene Smad4 (DPC4) at chromosome 18q21.1 belongs to the Smad family, which mediates the TGFbeta signaling pathway suppressing epithelial cell growth. This review summarizes the mutational events of the Smad4 gene in human cancer.