Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Michiko Minegishi"'
Autor:
Haruhiko Akiyama, Hiroyuki Hino, Yuanzhe Li, Katsuhiko Shibuya, Akiko Furuta, Masashi Takanashi, Michiko Minegishi, Ito Kawakami, Nobutaka Hattori, Eizo Iseki, Yoshio Mitsuyama, Shinji Higashi, Koji Kasanuki, Heii Arai, Kiyoshi Sato, Kohshiro Fujisawa
Publikováno v:
Journal of the Neurological Sciences. 367:349-355
Clinical phenotypes of hereditary diffuse leukoencephalopathy with spheroids (HDLS), a familial progressive neurodegenerative disorder affecting the white matter of the brain, are heterogenous and may include behavioral and personality changes, memor
Autor:
Masato Hosokawa, Hiroaki Hino, Kiyoshi Sato, Koshiro Fujisawa, Yoshio Hirayasu, Daizo Kondo, Heii Arai, Tetsuaki Arai, Eizo Iseki, Katsuhiko Shibuya, Ryoko Yamamoto, Michiko Minegishi, Kenji Kosaka, Koji Kasanuki
Publikováno v:
Neuropathology. 35:280-288
The patient was a 72-year-old Japanese woman. At the age of 57, she started having difficulty performing daily work and developed agraphia. She also exhibited restlessness and loss of interest, and began to speak less. Thereafter, stereotypical behav
Autor:
Eizo Iseki, Yoshiko Furukawa, Shinji Higashi, Heii Arai, Kenji Kosaka, Omi Katsuse, Takashi Togo, Koji Kasanuki, Ryoko Yamamoto, Kiyoshi Sato, Michiko Minegishi, Hirotake Uchikado, Hiroshige Fujishiro, Hiroaki Hino
Publikováno v:
Journal of the Neurological Sciences. 314:111-119
We performed a quantitative neuropathological examination of the hypometabolic regions on FDG PET in dementia with Lewy bodies (DLB), Alzheimer's disease (AD) and control cases. When the DLB cases were divided into two groups according to concomitant
Autor:
Michiko Minegishi, Omi Katsuse, Heii Arai, Kiyoshi Sato, Keiji Wada, Darren J. Moore, Takashi Togo, Hiroshige Fujishiro, Kenji Kosaka, Yoshiko Furukawa, Eizo Iseki, Shinji Higashi, Koji Kasanuki, Hirotake Uchikado, Tomohiro Kabuta, Hiroaki Hino
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 70:264-280
There is emerging evidence implicating a role for the autophagy-lysosome pathway in the pathogenesis of Lewy body disease. We investigated potential neuropathologic and biochemical alterations of autophagy-lysosome pathway-related proteins in the bra
Publikováno v:
Journal of Neurochemistry. 115:423-437
GIGYF2 has been reported as a candidate gene for PARK11-linked Parkinson's disease (PD). Heterozygous knockout of GIGYF2 results in neurodegeneration, suggesting important roles for GIGYF2 (Grb10 interacting GYF protein 2) in the CNS. In this study,
Autor:
Kenji Kosaka, Takashi Togo, Koshiro Fujisawa, Michiko Minegishi, Ryoko Yamamoto, Omi Katsuse, Heii Arai, Eizo Iseki, Mari Yoshida, Shinji Higashi, Yoshiko Furukawa, Kiyoshi Sato, Norio Murayama, Hiroaki Hino, Yoshio Hashizume, Hirotake Uchikado
Publikováno v:
Dementia and Geriatric Cognitive Disorders. 27:214-223
Background/Aims: Semantic dementia is a subtype of frontotemporal lobar degeneration, of which an initial symptom is semantic aphasia. Semantic dementia pathologically corresponds to atypical Pick’s disease (aPiD), showing ubiq- uitin-positive incl
Autor:
Takashi Togo, Michiko Minegishi, Hirotake Uchikado, Heii Arai, Koshiro Fujisawa, Eizo Iseki, Kenji Kosaka, Shinji Higashi, Ryoko Yamamoto, Hiroaki Hino, Yoshiko Furukawa, Omi Katsuse
Publikováno v:
Brain Research. 1184:284-294
TAR-DNA-binding protein 43 (TDP-43) has been identified as a major component protein of ubiquitin-positive inclusions in brains from patients with frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral s
Autor:
Lees Andrew, Eizo Iseki, Haruhiko Akiyama, Kuniaki Tsuchiya, Takashi Togo, Norio Murayama, Ryoko Yamamoto, de Silva Rohan, Heii Arai, Omi Katsuse, Michiko Minegishi, Kenji Kosaka
Publikováno v:
Neuroscience Letters. 405:29-33
Limbic neurofibrillary tangle dementia (LNTD) is a subset of senile dementia characterized by numerous neurofibrillary tangles (NFT) in the hippocampal area, although there is an absence or scarcity of amyloid deposits (AM) throughout the brain. In t
Autor:
Daizo, Kondo, Hiroaki, Hino, Katsuhiko, Shibuya, Koshiro, Fujisawa, Kenji, Kosaka, Yoshio, Hirayasu, Ryoko, Yamamoto, Koji, Kasanuki, Michiko, Minegishi, Kiyoshi, Sato, Masato, Hosokawa, Tetsuaki, Arai, Heii, Arai, Eizo, Iseki
Publikováno v:
Neuropathology : official journal of the Japanese Society of Neuropathology. 35(3)
The patient was a 72-year-old Japanese woman. At the age of 57, she started having difficulty performing daily work and developed agraphia. She also exhibited restlessness and loss of interest, and began to speak less. Thereafter, stereotypical behav
Autor:
Eizo Iseki, Koji Kasanuki, Hiroshige Fujishiro, Daizo Kondo, Omi Katsuse, Heii Arai, Kenji Kosaka, Michiko Minegishi, Kiyoshi Sato, Hiroaki Hino
Publikováno v:
Neuroscience letters. 569
Hypocretin (Hcrt) is a neuropeptide synthesized in the lateral hypothalamus (LHT) that plays a key role in maintaining arousal state. In Parkinson's disease (PD), a narcolepsy-like syndrome is commonly seen, and a previous study showed substantial Hc