Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Michiko Hayase"'
Autor:
Hidetoshi Shindoh, Michiko Hayase, Yuko Aoki, Shinji Tsujii, Hirosato Ebiike, Kenichi Kawasaki, Miyako Masubuchi, Tatsuo Ohtsuka, Yasuhiko Shiratori, Kenji Morikami, Kiyoaki Sakata, Satoshi Sogabe, Nobuo Shimma, Toshihiko Fujii
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:4463-4478
The C-4 side chain modification of lead compound 1 has resulted in the identification of a potent and selective Candida albicans N-myristoyltransferase (CaNmt) inhibitor RO-09-4609, which exhibits antifungal activity against C. albicans in vitro. Fur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c318290eaeb164c3c7cec0aa6c5a6d8
https://doi.org/10.1016/s0968-0896(03)00429-2
https://doi.org/10.1016/s0968-0896(03)00429-2
Autor:
Kenji Morikami, Kenichi Kawasaki, Satoshi Sogabe, Nobuo Shimma, Pingli Liu, Toshihiko Fujii, Yuko Aoki, Miyako Masubuchi, Tatsuo Ohtsuka, Yasuhiko Shiratori, Kiyoaki Sakata, Michiko Hayase, Hirosato Ebiike, Hidetoshi Shindoh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:607-610
Modification of the C-2 position of a benzofuran derivative 6 (RO-09-4609), an N-myristoyltransferase (Nmt) inhibitor, has led us to discover antifungal agents that are active in a murine systemic candidiasis model. The drug design is based on the an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29f8412cbecee5ee8d45629afa5ed91
https://doi.org/10.1016/s0960-894x(01)00808-3
https://doi.org/10.1016/s0960-894x(01)00808-3
Autor:
Kiyoaki Sakata, Kenichi Kawasaki, Michiko Hayase, Hirosato Ebiike, Hidetoshi Shindoh, Tsunehisa Aoyama, Satoshi Sogabe, Kenji Morikami, Nobuo Shimma, Toshihiko Fujii, Yasuhiko Shiratori, Miyako Masubuchi, Tatsuo Ohtsuka, Satoshi Niizuma, Yuko Aoki
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(1)
A new series of acid-stable antifungal agents having strong inhibitory activity against Candida albicans N-myristoyltransferase (CaNmt) has been developed starting from acid-unstable benzofuranylmethyl aryl ether 2. The inhibitor design is based on X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94c9fd497d860f375d6ad64c2fd84c7
https://pubmed.ncbi.nlm.nih.gov/12467623
https://pubmed.ncbi.nlm.nih.gov/12467623