Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michiko Hanazono"'
Autor:
Thao Thi Thanh Nguyen, Masato Shingyoji, Michiko Hanazono, Boya Zhong, Takao Morinaga, Yuji Tada, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Abstract A majority of mesothelioma specimens were defective of p14 and p16 expression due to deletion of the INK4A/ARF region, and the p53 pathway was consequently inactivated by elevated MDM2 functions which facilitated p53 degradaton. We investiga
Externí odkaz:
https://doaj.org/article/a33b3973c63c4e3da9ba0af8d938437e
Autor:
Yiyang Qin, Ikuo Sekine, Michiko Hanazono, Takao Morinaga, Mengmeng Fan, Yuichi Takiguchi, Yuji Tada, Masato Shingyoji, Naoto Yamaguchi, Masatoshi Tagawa
Publikováno v:
Molecular Oncology, Vol 13, Iss 6, Pp 1419-1432 (2019)
Pemetrexed (PEM) inhibits DNA and RNA synthesis and is currently one of the first‐line agents for mesothelioma. PEM suppresses the activities of several enzymes involved in purine and pyrimidine synthesis, and elevated activity of these enzymes in
Externí odkaz:
https://doaj.org/article/455ab0add9c64db28e0ba6554b010481
Autor:
Yiyang Qin, Ikuo Sekine, Mengmeng Fan, Yuichi Takiguchi, Yuji Tada, Masato Shingyoji, Michiko Hanazono, Naoto Yamaguchi, Masatoshi Tagawa
Publikováno v:
Cancer Cell International, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background Pemetrexed (PEM) is an anti-cancer agent targeting DNA and RNA synthesis, and clinically in use for mesothelioma and non-small cell lung carcinoma. A mechanism of resistance to PEM is associated with elevated activities of several
Externí odkaz:
https://doaj.org/article/ad934b0dab264311b72721325c553d40
Autor:
Takao Morinaga, Thảo Thi Thanh Nguyễn, Boya Zhong, Michiko Hanazono, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima, Masatoshi Tagawa
Publikováno v:
Virology Journal, Vol 14, Iss 1, Pp 1-10 (2017)
Abstract Background Genetically modified adenoviruses (Ad) with preferential replications in tumor cells have been examined for a possible clinical applicability as an anti-cancer agent. A simple method to detect viral and cellular proteins is valuab
Externí odkaz:
https://doaj.org/article/174d5b8dd5d84b5091fb4d01f2ff172a
Autor:
Shogo Moriya, Michiko Hanazono, Takeshi Fukuhara, Katsuro Iwase, Nobutaka Hattori, Masaki Takiguchi
Publikováno v:
Cellular and molecular life sciences : CMLS. 79(5)
Lewy body (LB), which mainly consists of abnormal α-synuclein (αS) aggregates, is a histological hallmark of Parkinson's disease (PD). αS aggregation and LB inclusions are induced by spreading αS fibrils to neurons; therefore, the formation and t
Autor:
Masato Shingyoji, Thi Thanh Nguyễn, Masatoshi Tagawa, Hideaki Shimada, Takao Morinaga, Michiko Hanazono, Kenzo Hiroshima, Yuji Tada, Boya Zhong
Publikováno v:
Apoptosis. 25:535-547
A majority of mesothelioma had the wild-type p53 genotype but was defective of p53 functions primarily due to a genetic defect in INK4A/ARF region. We examined a growth suppressive activity of CP-31398 which was developed to restore the p53 functions
Autor:
Michiko Hanazono, Kenzo Hiroshima, Boya Zhong, Masato Shingyoji, Yuji Tada, Takao Morinaga, Thao Thi Thanh Nguyen, Masatoshi Tagawa, Hideaki Shimada
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
A majority of mesothelioma specimens were defective of p14 and p16 expression due to deletion of the INK4A/ARF region, and the p53 pathway was consequently inactivated by elevated MDM2 functions which facilitated p53 degradaton. We investigated a rol
Autor:
Masatoshi Tagawa, Ikuo Sekine, Yuji Tada, Masato Shingyoji, Yiyang Qin, Yuichi Takiguchi, Naoto Yamaguchi, Takao Morinaga, Michiko Hanazono, Mengmeng Fan
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 13, Iss 6, Pp 1419-1432 (2019)
Molecular Oncology, Vol 13, Iss 6, Pp 1419-1432 (2019)
Pemetrexed (PEM) inhibits DNA and RNA synthesis and is currently one of the first‐line agents for mesothelioma. PEM suppresses the activities of several enzymes involved in purine and pyrimidine synthesis, and elevated activity of these enzymes in
Autor:
Yuichi Takiguchi, Masato Shingyoji, Yuji Tada, Michiko Hanazono, Mengmeng Fan, Naoto Yamaguchi, Ikuo Sekine, Yiyang Qin, Masatoshi Tagawa
Publikováno v:
Cancer Cell International, Vol 17, Iss 1, Pp 1-11 (2017)
Cancer Cell International
Cancer Cell International
Background Pemetrexed (PEM) is an anti-cancer agent targeting DNA and RNA synthesis, and clinically in use for mesothelioma and non-small cell lung carcinoma. A mechanism of resistance to PEM is associated with elevated activities of several enzymes
Autor:
Thảo Thi Thanh Nguyễn, Takao Morinaga, Masatoshi Tagawa, Yuji Tada, Kenzo Hiroshima, Ikuo Sekine, Hideaki Shimada, Masato Shingyoji, Koichiro Tatsumi, Michiko Hanazono, Boya Zhong
Publikováno v:
Virology Journal, Vol 14, Iss 1, Pp 1-10 (2017)
Virology Journal
Virology Journal
Background Genetically modified adenoviruses (Ad) with preferential replications in tumor cells have been examined for a possible clinical applicability as an anti-cancer agent. A simple method to detect viral and cellular proteins is valuable to mon