Výsledky vyhledávání - "Michihiro Ohtsubo"

Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein

Autor: Yorishige Imamura, Michihiro Ohtsubo, Tsuyoshi Ide, Hideaki Shimada, Yosuke Mizukami, Masashi Eto, Misa Ohtaguro

Publikováno v: Journal of Biochemical and Molecular Toxicology. 24:230-234

The inhibitory effects of flavonoids on the human cytochrome P450 1A2 (CYP1A2) were examined. Among flavonoids tested, galangin, kaempferol, chrysin, and apigenin were potent inhibitors. Although apigenin belonging to flavones and genistein belonging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15530758f3f5e568330c766824c68e6e
https://doi.org/10.1002/jbt.20328

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A Distinct mRNA Encoding a Soluble Form of ICAM-1 Molecule Expressed in Human Tissues

Autor: Toru Wakatsuki, Minoru Ishizawa, Michihiro Ohtsubo, Mikio Yamamoto, Nariyoshi Shinomiya, Fumihiro Kimura, Kotohiko Kimura

Publikováno v: Cell Adhesion and Communication. 3:283-292

A soluble form of ICAM-1 (sICAM-1) have been observed in normal human serum (Rothlein et al., J. Immunol. 147, 3788-3793) and at elevated levels in inflammatory and tumor bearing status (Seth et al., Lancet, 338, 83-84; Giavazzi et al., Canc. Res. 52

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8a88b3d7b6693ddded1aaf8398ce81
https://doi.org/10.3109/15419069509081014

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Site-directed mutagenesis of Asp-376, the catalytic phosphorylation site, and Lys-507, the putative ATP-binding site, of the α-subunit of Torpedo californica

Autor: Shunsuke Noguchi, Kazuo Takeda, Michihiro Ohtsubo, Masaru Kawamura, Michiaki Morohashi

Publikováno v: Biochimica et Biophysica Acta (BBA) - Biomembranes. 1021:157-160

Point mutations of Asp-376 of the alpha-subunit of Torpedo californica Na+/K(+)-ATPase (the site of phosphorylation during the catalytic cycle) to Asn, Glu or Thr led to virtual abolishment of Na+/K(+)-ATPase activity and ouabain-binding capacity. Re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3fb0f2945ed83fed5fa1448e11d57e
https://doi.org/10.1016/0005-2736(90)90028-m

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Invitro mutated β subunits from the F1-ATPase of the thermophilic bacterium, PS3, containing glutamine in place of glutamic acid in positions 190 or 201 assembles with the α and γ subunits to produce inactive complexes

Autor: Michihiro Ohtsubo, Masasuke Yoshida, Takayasu Date, Masafumi Yohda, Yasuo Kagawa, Shigeo Ohta

Publikováno v: Biochemical and Biophysical Research Communications. 146:705-710

Using site-directed mutagenesis, Glu-190 or Glu-201 of the beta subunit of the F1-ATPase from the thermophilic bacterium PS3 were replaced with glutamine. It was possible to reconstitute complexes of the mutated beta subunits with alpha and gamma sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bc99bd4d80b958a931ec8f0b9dbc59
https://doi.org/10.1016/0006-291x(87)90586-9

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Regional Difference in Mechanical Properties of the Cell Surface in Dividing Echinoderm Eggs*. (mechanical properties/cell surface/sea urchin eggs/starfish eggs/cleavage)

Autor: Michihiro Ohtsubo, Yukio Hiramoto

Publikováno v: Development, Growth and Differentiation. 27:371-383

Stiffness of the cell was surface was determined in fertilized sea urchin and starfish eggs by measuring the mechanical resistivity of the cell surface against negative pressure applied to a restricted part with a micropipette in contact with the cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d6183e395a57335d287c0504cb4cce9
https://doi.org/10.1111/j.1440-169x.1985.00371.x

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Ouabain sensitivity of a chimeric alpha subunit (Torpedo/rat) of the (Na,K)ATPase expressed in Xenopus oocyte

Autor: Kazuo Takeda, Michihiro Ohtsubo, Toshiko Ohta, Shunsuke Noguchi, Masaru Kawamura

Publikováno v: Biochemical and biophysical research communications. 155(3)

A cDNA for a chimeric alpha subunit of the (Na,K)ATPase was constructed and expressed in Xenopus oocytes in order to elucidate structural features involved in ouabain sensitivity. A chimeric alpha subunit, in which the N-terminal 165 amino acid seque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e0a17f15eb536bf775caac47d6673a4
https://pubmed.ncbi.nlm.nih.gov/2845966

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Expression of active alpha-3 subunit of rat brain Na+,K+-ATPase from the messenger RNA injected into Xenopus oocytes

Autor: Michihiro Ohtsubo, Yukichi Hara, Shunsuke Noguchi, Makoto Nakao, Toshiyuki Kojima, Masaru Kawamura

Publikováno v: Biochemical and biophysical research communications. 163(1)

Cloned cDNA encoding the so-far uncharacterized alpha-3 subunit of rat brain Na + ,K + -ATPase (Hara et al. (1987) J. Biochem. 102, 43–58, Shull et al. (1986) Biochemistry 25, 8125–8132) was incorporated into a vector carrying the SP6 promoter. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6da163ef971ab360eeb405d59b38d78
https://pubmed.ncbi.nlm.nih.gov/2549984

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