Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Michihiko SUZUKI"'
Publikováno v:
Acta Crystallographica Section D Structural Biology. 79:435-441
Structure determination of G-protein-coupled receptors (GPCRs) is key for the successful development of efficient drugs targeting GPCRs. BRIL is a thermostabilized apocytochrome b 562 (with M7W/H102I/R106L mutations) from Escherichia coli and is ofte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23bc1fed0271d985cce35a45e96877fb
https://doi.org/10.1107/s205979832300311x
https://doi.org/10.1107/s205979832300311x
Autor:
Yasuhiko Otsuki, Michihiko Suzuki, Keiko Kin, Masao Suzuki, Yutaka Kobayashi, Wataru Takarada, Takeshi Kikutani
Publikováno v:
Nihon Reoroji Gakkaishi. 50:197-217
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f20f2c2d40191d44ad064ec65aad1231
https://doi.org/10.1678/rheology.50.197
https://doi.org/10.1678/rheology.50.197
Autor:
Ayumi, Kaneda, Toshihiro, Seike, Tomohiro, Danjo, Takahiro, Nakajima, Nobumasa, Otsubo, Daisuke, Yamaguchi, Yoshiro, Tsuji, Kaori, Hamaguchi, Mai, Yasunaga, Yoichi, Nishiya, Michihiko, Suzuki, Jun-Ichi, Saito, Rie, Yatsunami, Satoshi, Nakamura, Yoshitaka, Sekido, Kiyotoshi, Mori
Publikováno v:
Am J Cancer Res
The Hippo signaling pathway regulates cell fate and organ development. In the Hippo pathway, transcriptional enhanced associate domain (TEAD) which is a transcription factor is activated by forming a complex with yes-associated protein 1 (YAP1) or tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6b9cd2e0dae781e69fc45755972dc3ea
https://pubmed.ncbi.nlm.nih.gov/33415007
https://pubmed.ncbi.nlm.nih.gov/33415007
Autor:
Haruka, Kinosada, Ryoko, Okada-Iwasaki, Kana, Kunieda, Minami, Suzuki-Imaizumi, Yuichi, Takahashi, Hikaru, Miyagi, Michihiko, Suzuki, Keiichi, Motosawa, Miwa, Watanabe, Motoya, Mie, Toshihiko, Ishii, Hiroshi, Ishida, Jun-Ichi, Saito, Ryuichiro, Nakai
Publikováno v:
Am J Cancer Res
The Wnt/β-catenin pathway, which is associated with disease progression, is activated in many cancers. Tankyrase (TNKS) has received attention as a target molecule for Wnt/β-catenin pathway inhibition. We identified K-476, a novel TNKS inhibitor, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::783b31059e8594860eda378059de9783
https://pubmed.ncbi.nlm.nih.gov/33520373
https://pubmed.ncbi.nlm.nih.gov/33520373
Autor:
Chiyo Suno, Hikaru Miyagi, Jun-Ichi Saito, Michihiko Suzuki, Yuichi Takahashi, Hidetsugu Asada, So Iwata, Mai Yasunaga
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
G-protein-coupled receptors (GPCRs)—the largest family of cell-surface membrane proteins—mediate the intracellular signal transduction of many external ligands. Thus, GPCRs have become important drug targets. X-ray crystal structures of GPCRs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6849ff98e35835552eba59c650542adb
https://doi.org/10.1038/s41598-020-68355-x
https://doi.org/10.1038/s41598-020-68355-x
Autor:
Yuichi Takahashi, Satoshi Shuto, Jun-Ichi Saito, Kimihisa Ueno, Tomohiro Tamura, Michihiko Suzuki, Kazuki Henmi, Masahiro Matsubara, Takeshi Kuboyama, Yamamoto Keisuke, Arata Yanagisawa
Publikováno v:
Journal of Medicinal Chemistry. 61:10067-10083
A novel class of PPARγ ligand 1 (EC50 = 197 nM) with a dibenzoazepin scaffold was identified through high-throughput screening campaign. To avoid the synthetically troublesome chiral center of 1, its conformational analysis using the MacroModel was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce88365240ca4ee46874f01676f40c25
https://doi.org/10.1021/acs.jmedchem.8b01200
https://doi.org/10.1021/acs.jmedchem.8b01200
Autor:
Takahiro Nakajima, Hikaru Miyagi, Fumikazu Shinohara, Asana Makino, Atsuko Sato, Yasuo Koda, Tomoyuki Nishikawa, Taiji Oashi, Kaori Hamaguchi, Yukihide Tomari, Yuichi Takahashi, Michihiko Suzuki, Junichiro Yamamoto, Toshimasa Harumoto, Jun-Ichi Saito, Yuki Takayama, Takashi Sawada
Publikováno v:
RNA
Small interfering RNAs (siRNAs) can be utilized not only as functional biological research tools but also as therapeutic agents. For the clinical use of siRNA as drugs, various chemical modifications have been used to improve the activity of siRNA dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609e2b6448ee63ab91be85f7242f72ba
https://pubmed.ncbi.nlm.nih.gov/33177188
https://pubmed.ncbi.nlm.nih.gov/33177188
Micro CTD data logger reveals short-term excursions of Japanese sea bass from seawater to freshwater
Autor:
Tomohiko Mori, Naoyuki Miyata, Katsufumi Sato, Michihiko Suzuki, Nobuyuki Miyazaki, Masaaki Kagehira
Publikováno v:
Aquatic Biology, Vol 25, Pp 97-106 (2016)
We conducted calibration tests and field deployments of a newly developed micro CTD data logger on Japanese sea bass Lateolabrax japonicus to measure fine-scale movement and reconstruct micro-salinity profiles of estuarine habitat. In June, July and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6978c43e833a1a4c2a904b3cd6b86329
https://doi.org/10.3354/ab00656
https://doi.org/10.3354/ab00656
Autor:
Shintaro Hosoe, Hiroshi Kodaira, Masahiro Matsubara, Jun-Ichi Saito, Kimihisa Ueno, Takeshi Uemori, Yuichi Takahashi, Tomohiro Tamura, Keiko Nagata, Yamamoto Keisuke, Michihiko Suzuki, Nakamura Rina, Satoshi Shuto
Publikováno v:
Bioorganic & Medicinal Chemistry / Bioorganic and Medicinal Chemistry. 27(22):115122
We previously identified dibenzooxepine derivative 1 as a potent PPARγ ligand with a unique binding mode owing to its non-thiazolidinedione scaffold. However, while 1 showed remarkably potent MKN-45 gastric cancer cell aggregation activity, an indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9745266e23aa35ca0ee84694ed58b04c
http://hdl.handle.net/2115/83295
http://hdl.handle.net/2115/83295
Autor:
Toshihiko Ishii, Mai Yasunaga, Kaori Hamaguchi, Daisuke Yamaguchi, Ayumi Kaneda, Yoichi Nishiya, Nobumasa Otsubo, Michihiko Suzuki, Tomohiro Danjo, Tomoko Hamada, Kensuke Aida, Yoshiro Tsuji, Takeshi Uemori, Ryuichiro Nakai, Takahiro Nakajima, Toshihiro Seike, Kensuke Myojo, Hideyuki Onodera, Jun-Ichi Saito
Publikováno v:
Cancer Research. 79:3086-3086
Objective: Hippo signaling pathway is known to regulate organ development. In Hippo signaling pathway, YAP or TAZ works as a transcriptional co-activator and forms a transcriptional complex with TEAD. In several cancers, upstream factors in Hippo pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a303092c948a990744890cb69c81408f
https://doi.org/10.1158/1538-7445.am2019-3086
https://doi.org/10.1158/1538-7445.am2019-3086