Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michiharu Yoshiike"'
Autor:
Michiharu Yoshiike, Tetsuo Nakayama, Katsuyasu Ishida, Ryo Arakane, Akiko Takahama, Ryosuke Annaka, Fumihiko Takeshita
Publikováno v:
Vaccine. 33:6650-6658
Background Although the elderly are at high risk for influenza, the immunogenicity in the elderly is lower than that in younger adults. We developed the new type of seasonal influenza vaccine with the novel intradermal (ID) injection system. In the p
Autor:
Michiharu Yoshiike, Fumihiko Takeshita, Tetsuo Nakayama, Katsuyasu Ishida, Hitomi Nakatani, Emi Fujisaki, Akiko Takahama, Ryo Arakane
Publikováno v:
Vaccine. 33:6340-6350
Background Recent clinical evidence indicates that an intradermal (ID) delivery of vaccines confers superior immunogenicity as compared to a standard intramusclular or subcutaneous (SC) delivery. Methods In this exploratory study, 600 healthy adults
Autor:
Miho Kazui, Osamu Okazaki, Nagy A. Farid, Katsunobu Hagihara, Atsushi Kurihara, Kokichi Honda, Toshihiko Ikeda, Michiharu Yoshiike
Publikováno v:
Drug Metabolism and Disposition. 37:2145-2152
The efficiency and interindividual variability in bioactivation of prasugrel and clopidogrel were quantitatively compared and the mechanisms involved were elucidated using 20 individual human liver microsomes. Prasugrel and clopidogrel are converted
Autor:
Tsutomu Suzuki, Hirokazu Mizoguchi, Michiharu Yoshiike, Junzo Kamei, Hiroshi Nagase, Miwa Misawa
Publikováno v:
Japanese Journal of Pharmacology. 66:131-138
Effects of highly selective delta-opioid receptor antagonists on the morphine-induced place preference in ddY and mu 1-opioid receptor deficient CXBK mice were investigated. Pretreatment with naltrindole (NTI: a non-selective delta-opioid receptor an
Publikováno v:
Life Sciences. 53:PL365-PL370
The effects of Ca 2+ channel blockers on the development of physical dependence on diazepam were examined in mice. Co-administration of flunarizine (T-type Ca 2+ channel sensitive blocker), but not of either nifedipine or diltiazem (L-type Ca 2+ chan
Autor:
Miwa Misawa, Tsutomu Suzuki, Makoto Tsuda, Hirokazu Mizoguchi, Michiharu Yoshiike, Naomi Shirayama
Publikováno v:
Life sciences. 54(9)
The effects of ondansetron, a 5-HT3 antagonist, on the development of physical dependence on diazepam were examined in rats using a drug-admixed food method. Rats were treated with diazepam or diazepam in combination with ondansetron for 26 days. Aft
Autor:
Masahiko Funada, Junzo Kamei, Miwa Misawa, Tsutomu Suzuki, Hirokazu Mizoguchi, Michiharu Yoshiike
Publikováno v:
Neuroscience letters. 160(2)
The effect of pretreatment with cyclosporine A, an immunosuppressant, on the morphine-induced place preference was examined in ddY and mu1 opioid receptor-deficient CXBK mice. Morphine produced a significant preference for the drug-associated place i
Autor:
Masahiko Funada, Tsutomu Suzuki, Michiharu Yoshiike, Junzo Kamei, Miwa Misawa, Hiroshi Nagase
Publikováno v:
Regulatory Peptides. 53:S45-S46
Effects of highly selective δ opioid antagonists on the morphine-induced place preference in ddY and μ 1 opioid receptor-deficient CXBK mice were investigated. Pretreatment with naltrindole (NTI: a non-selective δ opioid antagonist), 7-benzylidene
Publikováno v:
Japanese Journal of Pharmacology. 58:74