Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Michiel Krols"'
1
ESYT1 tethers the endoplasmic reticulum to mitochondria and is required for mitochondrial lipid and calcium homeostasis
Autor: Alexandre Janer, Jordan L. Morris, Michiel Krols, Hana Antonicka, Mari J. Aaltonen, Zhen-Yuan Lin, Anne-Claude Gingras, Julien Prudent, Eric A. Shoubridge
SUMMARYMitochondria interact with the endoplasmic reticulum (ER) at structurally and functionally specialized membrane contact sites known as mitochondria-ER contact sites (MERCs). MERCs are crucial for a myriad of physiological functions including l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b55a63d56edb1c56765c922acd394791
https://doi.org/10.1101/2022.11.14.516495
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2
MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control
Autor: Tim König, Hendrik Nolte, Mari J. Aaltonen, Takashi Tatsuta, Michiel Krols, Thomas Stroh, Thomas Langer, Heidi M. McBride
Publikováno v: Nat Cell Biol
Mitochondrial-derived vesicles (MDVs) are implicated in diverse physiological processes-for example, mitochondrial quality control-and are linked to various neurodegenerative diseases. However, their specific cargo composition and complex molecular b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3350ad9f89df2610c467f9d7697c414
https://hdl.handle.net/21.11116/0000-000A-FA3C-A
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3
The enigma of an interconnected mitochondrial reticulum: new insights into mitochondrial fusion
Autor: Sevan Mattie, Michiel Krols, Heidi M. McBride
Publikováno v: Current Opinion in Cell Biology. 59:159-166
It has been over 20 years since the identification of the first GTPases that regulate mitochondrial fusion in drosophila, yeast, and mammalian cells. While the molecular identification of these players solidified the new field of mitochondrial dynami
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96cfc13f8ec61c3530e59c6d97096eb
https://doi.org/10.1016/j.ceb.2019.05.004
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4
Sensory neuropathy-causing mutations in ATL3 affect ER–mitochondria contact sites and impair axonal mitochondrial distribution
Autor: Ingo Kurth, Bob Asselbergh, Michiel Krols, Sophie Janssens, Geert Bultynck, Riet De Rycke, Franz-Josef Müller, Vicky De Winter, Alexandre Seyer, Vincent Timmerman
Publikováno v: Human molecular genetics: HMG online 28(4), 615-627 (2019). doi:10.1093/hmg/ddy352
Human Molecular Genetics
Human molecular genetics
HUMAN MOLECULAR GENETICS
Human molecular genetics: HMG online 28(4), 615-627 (2019). doi:10.1093/hmg/ddy352
Published by Oxford Univ. Press, Oxford
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588b7a29c2db46c359e336789c6aeafd
https://publications.rwth-aachen.de/record/757146
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5
ER–Mitochondria contact sites: A new regulator of cellular calcium flux comes into play
Autor: Sophie Janssens, Michiel Krols, Geert Bultynck
Publikováno v: The Journal of Cell Biology
The journal of cell biology
Endoplasmic reticulum (ER)–mitochondria membrane contacts are hotspots for calcium signaling. In this issue, Raturi et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201512077) show that the thioredoxin TMX1 inhibits the calcium pump SERCA2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef1f2bd3066dff40de32e3a6baba9fa
https://doi.org/10.1083/jcb.201607124
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6
Sensory-Neuropathy-Causing Mutations in ATL3 Cause Aberrant ER Membrane Tethering
Autor: Michiel Krols, Saskia Lippens, Leonardo Almeida-Souza, Savvas N. Savvides, Ingo Kurth, Franz-Josef Müller, Bob Asselbergh, Vincent Timmerman, Sammy Detry, Riet De Rycke, Harvey T. McMahon, Sophie Janssens, Vicky De Winter, Anna Kremer
Publikováno v: Cell reports 23(7), 2026-2038 (2018). doi:10.1016/j.celrep.2018.04.071
Cell reports
CELL REPORTS
The endoplasmic reticulum (ER) is a complex network of sheets and tubules that is continuously remodeled. The relevance of this membrane dynamics is underscored by the fact that mutations in atlastins (ATLs), the ER fusion proteins in mammals, cause
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8916b456e3b8105ce816e4f6c4494bb0
https://publications.rwth-aachen.de/record/750326
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7
Developing 3D SEM in a broad biological context
Autor: Sophie Janssens, C Theunis, Brigitte Schepens, J-C Larsimont, Matyáš Fendrych, Christopher J. Guérin, Alain Goossens, Saskia Lippens, Xavier Saelens, Cédric Blanpain, C Mc Guire, R Van Brempt, Véronique Timmerman, Sonia Bartunkova, Bob Asselbergh, A Schertel, Y Visser, Moritz K. Nowack, Michiel Krols, Matthew Holt, Anneke Kremer, Michal Slezak
Publikováno v: Journal of Microscopy. 259:80-96
When electron microscopy (EM) was introduced in the 1930s it gave scientists their first look into the nanoworld of cells. Over the last 80 years EM has vastly increased our understanding of the complex cellular structures that underlie the diverse f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::079176c3b093877ce626897186cbe0be
https://doi.org/10.1111/jmi.12211
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8
Sensory neuropathy-causing mutations in ATL3 cause aberrant ER membrane tethering
Autor: Anna Kremer, Saskia Lippens, Sophie Janssens, Bob Asselbergh, Sammy Detry, Vincent Timmerman, Harvey T. McMahon, Riet De Rycke, Ingo Kurth, Vicky De Winter, Leonardo Almeida-Souza, Michiel Krols, Franz-Josef Müller, Savvas N. Savvides
SUMMARYThe ER is a complex network of sheets and tubules that is continuously being remodeled. The relevance of this membrane dynamics is underscored by the fact that mutations in Atlastins (ATL), the ER fusion proteins in mammals, cause neurodegener
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29507b8213d3d39db5b704929d4aeecc
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9
HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis
Autor: Sanjeev Gupta, Deepu Oommen, Katarzyna Mnich, Reka Chakravarthy, Adrienne M. Gorman, Karen M. Doyle, Michiel Krols, Sophie Janssens, Donna Kennedy, Afshin Samali, Leonardo Almeida-Souza, Svetlana Saveljeva, Vincent Timmerman
Publikováno v: Cell Death and Disease
Cell Death & Disease
CELL DEATH & DISEASE
BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells overexpressing heat shock protein B
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05893e9a49ecf4295112db387dbe020
https://hdl.handle.net/10067/1457320151162165141
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10
ORMDL3 expression levels have no influence on the activity of serine palmitoyltransferase
Autor: Peter Vollenweider, Wendy Toussaint, Arnold von Eckardstein, Nincy Debeuf, Daniela Ernst, Thorsten Hornemann, Sophie Janssens, Michiel Krols, Leen Vanhoutte, Bart N. Lambrecht, Irina Alecu, Zoltán Kutalik, Assem Zhakupova
Publikováno v: FASEB Journal, 30(12), 4289-4300. FASEB
The FASEB journal
ORMDL proteins are believed to be negative regulators of serine palmitoyltransferase (SPT), which catalyzes the first and rate limiting step in sphingolipid (SL) de novo synthesis. Several single-nucleotide polymorphisms (SNPs) that are close to the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad6573c301d53a07e24fee558fe279d
https://pubmed.ncbi.nlm.nih.gov/27645259
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