Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michiel J. Thiecke"'
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Genetic variants showing associations with specific biological traits and diseases detected by genome-wide association studies (GWAS) commonly map to non-coding DNA regulatory regions. Many of these regions are located considerable distances away fro
Externí odkaz:
https://doaj.org/article/502ff5588bf84dc98184cb382a6f0b34
Autor:
Truus E. M. Abbink, Lisanne E. Wisse, Ermelinda Jaku, Michiel J. Thiecke, Daniel Voltolini‐González, Hein Fritsen, Sander Bobeldijk, Timo J. terBraak, Emiel Polder, Nienke L. Postma, Marianna Bugiani, Eduard A. Struijs, Mark Verheijen, Nina Straat, Sophie van derSluis, Adri A. M. Thomas, Douwe Molenaar, Marjo S. van derKnaap
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 8, Pp 1407-1422 (2019)
Abstract Objective Vanishing white matter (VWM) is a fatal, stress‐sensitive leukodystrophy that mainly affects children and is currently without treatment. VWM is caused by recessive mutations in eukaryotic initiation factor 2B (eIF2B) that is cru
Externí odkaz:
https://doaj.org/article/bc70e13747d84b12b5b25ba59f4dcbfe
Autor:
Jessie D. Trujillo, Emily R. Miraldi, Jan Bakker, Benjamin R. tenOever, Andre L. Moreira, Helen Ray-Jones, Ivan Marazzi, Simin Zheng, Nan Zhao, Laura Campisi, Michael Schotsaert, Zeyu Zhu, Sven Heinz, Elaine Shum, Christopher Benner, Jessica Sook Yuin Ho, Anna Junxia Zhang, Adolfo García-Sastre, Sreeja Parameswaran, Joseph A. Wayman, Matthew T. Weirauch, Anand D. Jeyasekharan, Yesai Fstkchyan, Igor Morozov, Wen-Chun Liu, Minji Byun, Sumit K. Chanda, Sabarish V. Indran, Natasha N. Gaudreault, Mikhail Spivakov, Honglin Chen, Alba Escalera, Bobo Wing-Yee Mok, Kris M. White, Juergen A. Richt, Mariano Carossino, Valeriya Malysheva, Randy A. Albrecht, Tristan X. Jordan, Teresa Aydillo, Robert Sebra, Betsaida Salom Melo, Andrew Chak-Yiu Lee, Sonia Jangra, Udeni B. R. Balasuriya, David A. Meekins, Ernesto Guccione, Siu Ying Lau, Soner Yildiz, Michiel J. Thiecke, David A. Kaufman, Raveen Rathnasinghe, Honglian Liu
Publikováno v:
Cell, 184(10), 2618-2632.e17. Cell Press
Cell, vol 184, iss 10
Cell
Cell, vol 184, iss 10
Cell
The ongoing pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently affecting millions of lives worldwide. Large retrospective studies indicate that an elevated level of inflammatory cytokines and pro-inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d169781a64bf58af62230f5b19d8e6ad
https://pure.eur.nl/en/publications/c6a3d84a-3a2d-4ff6-9904-1d7f6b018446
https://pure.eur.nl/en/publications/c6a3d84a-3a2d-4ff6-9904-1d7f6b018446
Autor:
Sander Bobeldijk, Mark H. G. Verheijen, Adri A. M. Thomas, Douwe Molenaar, Eduard A. Struijs, Marianna Bugiani, Timo J. ter Braak, Nienke L. Postma, Truus Em Abbink, Lisanne E. Wisse, Daniel Voltolini-González, Emiel Polder, Sophie van der Sluis, Michiel J. Thiecke, Ermelinda Jaku, Marjo S. van der Knaap, Hein Fritsen, Nina Straat
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 6, Iss 8, Pp 1407-1422 (2019)
Abbink, T E M, Wisse, L E, Jaku, E, Thiecke, M J, Voltolini-González, D, Fritsen, H, Bobeldijk, S, ter Braak, T J, Polder, E, Postma, N L, Bugiani, M, Struijs, E A, Verheijen, M, Straat, N, van der Sluis, S, Thomas, A A M, Molenaar, D & van der Knaap, M S 2019, ' Vanishing white matter: deregulated integrated stress response as therapy target ', Annals of Clinical and Translational Neurology, vol. 6, no. 8, pp. 1407-1422 . https://doi.org/10.1002/acn3.50826
Abbink, T E M, Wisse, L E, Jaku, E, Thiecke, M J, Voltolini-González, D, Fritsen, H, Bobeldijk, S, ter Braak, T J, Polder, E, Postma, N L, Bugiani, M, Struijs, E A, Verheijen, M, Straat, N, van der Sluis, S, Thomas, A A M, Molenaar, D & van der Knaap, M S 2019, ' Vanishing white matter : deregulated integrated stress response as therapy target ', Annals of Clinical and Translational Neurology, vol. 6, no. 8, pp. 1407-1422 . https://doi.org/10.1002/acn3.50826
Annals of Clinical and Translational Neurology, 6(8), 1407-1422. John Wiley and Sons Ltd
Annals of Clinical and Translational Neurology
Abbink, T E M, Wisse, L E, Jaku, E, Thiecke, M J, Voltolini-González, D, Fritsen, H, Bobeldijk, S, ter Braak, T J, Polder, E, Postma, N L, Bugiani, M, Struijs, E A, Verheijen, M, Straat, N, van der Sluis, S, Thomas, A A M, Molenaar, D & van der Knaap, M S 2019, ' Vanishing white matter: deregulated integrated stress response as therapy target ', Annals of Clinical and Translational Neurology, vol. 6, no. 8, pp. 1407-1422 . https://doi.org/10.1002/acn3.50826
Abbink, T E M, Wisse, L E, Jaku, E, Thiecke, M J, Voltolini-González, D, Fritsen, H, Bobeldijk, S, ter Braak, T J, Polder, E, Postma, N L, Bugiani, M, Struijs, E A, Verheijen, M, Straat, N, van der Sluis, S, Thomas, A A M, Molenaar, D & van der Knaap, M S 2019, ' Vanishing white matter : deregulated integrated stress response as therapy target ', Annals of Clinical and Translational Neurology, vol. 6, no. 8, pp. 1407-1422 . https://doi.org/10.1002/acn3.50826
Annals of Clinical and Translational Neurology, 6(8), 1407-1422. John Wiley and Sons Ltd
Annals of Clinical and Translational Neurology
Objective: Vanishing white matter (VWM) is a fatal, stress-sensitive leukodystrophy that mainly affects children and is currently without treatment. VWM is caused by recessive mutations in eukaryotic initiation factor 2B (eIF2B) that is crucial for i
Autor:
Jessica Sook Yuin Ho, Bobo Wing-Yee Mok, Laura Campisi, Tristan Jordan, Soner Yildiz, Sreeja Parameswaran, Joseph A Wayman, Natasha N Gaudreault, David A Meekins, Sabarish V. Indran, Igor Morozov, Jessie D Trujillo, Yesai S Fstkchyan, Raveen Rathnasinghe, Zeyu Zhu, Simin Zheng, Nan Zhao, Kris White, Helen Ray-Jones, Valeriya Malysheva, Michiel J Thiecke, Siu-Ying Lau, Honglian Liu, Anna Junxia Zhang, Andrew Chak-Yiu Lee, Wen-Chun Liu, Teresa Aydillo, Betsaida Salom Melo, Ernesto Guccione, Robert Sebra, Elaine Shum, Jan Bakker, David A. Kaufman, Andre L. Moreira, Mariano Carossino, Udeni B R Balasuriya, Minji Byun, Emily R Miraldi, Randy A Albrecht, Michael Schotsaert, Adolfo Garcia-Sastre, Sumit K Chanda, Anand D Jeyasekharan, Benjamin R TenOever, Mikhail Spivakov, Matthew T Weirauch, Sven Heinz, Honglin Chen, Christopher Benner, Juergen A Richt, Ivan Marazzi
Publikováno v:
bioRxiv
SUMMARYThe ongoing pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is currently affecting millions of lives worldwide. Large retrospective studies indicate that an elevated level of inflammatory cytokines and pro-infla
Autor:
Tobias Neumann, Mikhail Spivakov, Jan-Michael Peters, Wen Tang, Valeriya Malysheva, Michiel J. Thiecke, Gordana Wutz, Stephen Bevan, Stefan Schoenfelder, Matthias Muhar, Roman R. Stocsits, Peter Fraser, Johannes Zuber
It is currently assumed that 3D chromosomal organisation plays a central role in transcriptional control. However, recent evidence shows that steady-state transcription of only a minority of genes is affected by depletion of architectural proteins su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2299a3e16fa5822f8147d03146523245
https://doi.org/10.1101/2020.02.10.941989
https://doi.org/10.1101/2020.02.10.941989
Integrated Stress Response Deregulation underlies Vanishing White Matter and is a target for therapy
Autor:
Michiel J. Thiecke, Nina Straat, Eduard A. Struijs, Ermelinda Jaku, Sophie van der Sluis, Nienke L. Postma, Douwe Molenaar, Truus E.M. Abbink, Emiel Polder, Timo J. ter Braak, Lisanne E. Wisse, Hein Fritsen, Marianna Bugiani, Marjo S. van der Knaap, Adri A. M. Thomas, Daniel Voltolini-González, Sander Bobeldijk, Mark H. G. Verheijen
Vanishing white matter (VWM) is a fatal, stress-sensitive leukodystrophy that mainly affects children and is currently without treatment. VWM is caused by recessive mutations in eukaryotic initiation factor 2B (eIF2B) that is crucial for initiation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247f734a34582ebb188028f4ce1b07a0
https://doi.org/10.1101/460840
https://doi.org/10.1101/460840
Autor:
Biola M. Javierre, Oliver S. Burren, Steven P. Wilder, Roman Kreuzhuber, Steven M. Hill, Sven Sewitz, Jonathan Cairns, Steven W. Wingett, Csilla Várnai, Michiel J. Thiecke, Frances Burden, Samantha Farrow, Antony J. Cutler, Karola Rehnström, Kate Downes, Luigi Grassi, Myrto Kostadima, Paula Freire-Pritchett, Fan Wang, Hendrik G. Stunnenberg, John A. Todd, Daniel R. Zerbino, Oliver Stegle, Willem H. Ouwehand, Mattia Frontini, Chris Wallace, Mikhail Spivakov, Peter Fraser, Joost H. Martens, Bowon Kim, Nilofar Sharifi, Eva M. Janssen-Megens, Marie-Laure Yaspo, Matthias Linser, Alexander Kovacsovics, Laura Clarke, David Richardson, Avik Datta, Paul Flicek
Publikováno v:
Cell, 167, 5, pp. 1369-1384.e19
Cell, 167, 1369-1384.e19
Cell
Cell, 167, 1369-1384.e19
Cell
Summary Long-range interactions between regulatory elements and gene promoters play key roles in transcriptional regulation. The vast majority of interactions are uncharted, constituting a major missing link in understanding genome control. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93911ac66ad359777d0f77cf2f048cca
https://hdl.handle.net/2066/161816
https://hdl.handle.net/2066/161816
Autor:
Jan-Michael Peters, Wen Tang, Stefan Schoenfelder, Matthias Muhar, Valeriya Malysheva, Tobias Neumann, Mikhail Spivakov, Johannes Zuber, Gordana Wutz, Michiel J. Thiecke, Stephen Bevan, Roman R. Stocsits, Peter Fraser
Publikováno v:
Cell Reports
Cell Reports, 32 (3)
Cell Reports, 32 (3)
Summary It is currently assumed that 3D chromosomal organization plays a central role in transcriptional control. However, depletion of cohesin and CTCF affects the steady-state levels of only a minority of transcripts. Here, we use high-resolution C