Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Michiel Fokkelman"'
Autor:
Esmee Koedoot, Michiel Fokkelman, Vasiliki-Maria Rogkoti, Marcel Smid, Iris van de Sandt, Hans de Bont, Chantal Pont, Janna E. Klip, Steven Wink, Mieke A. Timmermans, Erik A. C. Wiemer, Peter Stoilov, John A. Foekens, Sylvia E. Le Dévédec, John W. M. Martens, Bob van de Water
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Triple-negative breast cancers (TNBC) have enhanced migratory behaviour. Here, the authors perform a phenotypic imaging-based RNAi screen to identify several genes associated with regulation of migratory phenotypes and show that one of the regulators
Externí odkaz:
https://doaj.org/article/720606fcf5f54cc0ae38a7db6f491bec
Autor:
Michiel Fokkelman, Wies Roosmalen, Vasiliki-Maria Rogkoti, Sylvia Le Dévédec, Benjamin Geiger, Bob Water
Publikováno v:
Bio-Protocol, Vol 6, Iss 1 (2016)
Cell migration is a highly complex and dynamic biological process, essential in several physiological phenomena and pathologies including cancer dissemination and metastasis formation. Thus understanding single cell migration is highly relevant and r
Externí odkaz:
https://doaj.org/article/f2879165803c4f29bbaec4abe9394154
Autor:
Eytan Ruppin, Nishanth Ulhas Nair, Joo Sang Lee, Michiel Fokkelman, Sridhar Hannenhalli, Benjamin G. Neel, Bob van de Water, Vasiliki-Maria Rogkoti, Richard Marcotte, Isaac Meilijson, Sylvia E. Le Dévédec, Avinash Das, Chiaro G. de Jong, Esmee Koedoot
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports, 9, 10989
Scientific Reports
Scientific Reports, 9, 10989
The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b90107213a59a3a3a97921d57bb922
http://link.springer.com/article/10.1038/s41598-019-47440-w
http://link.springer.com/article/10.1038/s41598-019-47440-w
Autor:
Sylvia E. Le Dévédec, Michiel Fokkelman, Anna. M. Timmermans, Chantal Pont, John W.M. Martens, John A. Foekens, Bob van de Water, Peter Stoilov, Marcel Smid, Hans de Bont, Erik A.C. Wiemer, Iris van de Sandt, Janna E. Klip, Vasiliki-Maria Rogkoti, Esmee Koedoot, Steven Wink
Publikováno v:
Nature Communications, 10(1), 2983
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, 10:2983. Nature Publishing Group
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, 10:2983. Nature Publishing Group
Nature Communications
Ttriple-negative breast cancer (TNBC) is an aggressive and highly metastatic breast cancer subtype. Enhanced TNBC cell motility is a prerequisite of TNBC cell dissemination. Here, we apply an imaging-based RNAi phenotypic cell migration screen using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2feece2f0728cd7c3f55eb14a625e103
http://hdl.handle.net/1887/79045
http://hdl.handle.net/1887/79045
Autor:
Wouter N. Leonhard, Leo S. Price, Tijmen H. Booij, Dorien J.M. Peters, Hester Bange, Kimberley Veraar, Johannes G. Dauwerse, Kuan Yan, Gerard J. P. van Westen, Anna J. Plugge, Michiel Fokkelman, Bob van de Water
Publikováno v:
Journal of Molecular Cell Biology
Journal of Molecular Cell Biology, 12(8), 644-653. OXFORD UNIV PRESS
Journal of Molecular Cell Biology, 12(8), 644-653
Journal of Molecular Cell Biology, 12(8), 644-653. OXFORD UNIV PRESS
Journal of Molecular Cell Biology, 12(8), 644-653
Polycystic kidney disease (PKD) is a prevalent genetic disorder, characterized by the formation of kidney cysts that progressively lead to kidney failure. The currently available drug tolvaptan is not well tolerated by all patients and there remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f3526c6faa19c44924c7852a954d44
https://doi.org/10.1093/jmcb/mjz029
https://doi.org/10.1093/jmcb/mjz029
Autor:
Erik A.C. Wiemer, Peter Stoilov, Iris van de Sandt, John W.M. Martens, Sylvia E. Le Dévédec, Esmee Koedoot, Vasiliki-Maria Rogkoti, John A. Foekens, Janna E. Klip, Marcel Smid, Michiel Fokkelman, Hans de Bont, Chantal Pont, Bob van de Water
Metastasis is the major cause of death in cancer patients and migration of cancer cells from the primary tumor to distant sites is the prerequisite of metastasis formation. Here we applied an imaging-based RNAi phenotypic cell migration screen using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6495327fc31379d44c0ad8e4d5f5ae94
https://doi.org/10.1101/479568
https://doi.org/10.1101/479568
Autor:
Richard Marcotte, Avinash Das, Nishanth Ulhas Nair, Michiel Fokkelman, Isaac Meilijson, Sylvia E. Le Dévédec, Joo Sang Lee, Eytan Ruppin, Benjamin G. Neel, Sridhar Hannenhalli, Chiaro G. de Jong, Vasiliki-Maria Rogkoti, Bob van de Water
The efficacy of prospective cancer treatments is routinely estimated by in vitro cell-line proliferation screens. However, it is unclear whether tumor aggressiveness and patient survival are influenced more by the proliferative or the migratory prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a038fe0ec31f89644489624bb0daa64f
Autor:
Johannes G. Dauwerse, Yu Qin, Steven J. Kunnen, Gerard J. P. van Westen, Dorien J.M. Peters, Michiel Fokkelman, Kuan Yan, Tijmen H Booij, Hester Bange, Bob van de Water, Wouter N. Leonhard, Leo S. Price
Publikováno v:
Slas Discovery, 22(8), 974-984
Slas Discovery
Slas Discovery
Polycystic kidney disease (PKD) is a prevalent disorder characterized by renal cysts that lead to kidney failure. Various signaling pathways have been targeted to stop disease progression, but most interventions still focus on alleviating PKD-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6260aac73a96c554a720dda0340d19
http://hdl.handle.net/1887/57122
http://hdl.handle.net/1887/57122
Autor:
Bram Herpers, Lisa Fredriksson, Kuan Yan, Marjo de Graauw, Michiel Fokkelman, John H. N. Meerman, Bob van de Water, Giulia Benedetti
Publikováno v:
Molecular Pharmacology. 84:128-138
Cis-diamminedichloroplatinum(II) (cisplatin)-induced renal proximal tubular apoptosis is known to be preceded by actin cytoskeleton reorganization, in conjunction with disruption of cell-matrix and cell-cell adhesion. In the present study, we show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f59f6a29decbbd827fe4a930aab9a86
https://doi.org/10.1124/mol.112.084053
https://doi.org/10.1124/mol.112.084053
Autor:
Janna E. Klip, Kuan Yan, Fons J. Verbeek, Michiel Fokkelman, Erik H.J. Danen, Hayri E. Balcioglu, Bob van de Water
Publikováno v:
SCIENTIFIC REPORTS
SCIENTIFIC REPORTS, 6, 31707
Scientific Reports
SCIENTIFIC REPORTS, 6, 31707
Scientific Reports
Cancer cells migrate from the primary tumour into surrounding tissue in order to form metastasis. Cell migration is a highly complex process, which requires continuous remodelling and re-organization of the cytoskeleton and cell-matrix adhesions. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5de6e925b7d3c1967dce497d3d5ede
https://doi.org/10.1038/srep31707
https://doi.org/10.1038/srep31707