Aortic Cross-Clamping and Reperfusion in Pigs Reduces Microvascular Oxygenation by Altered Systemic and Regional Blood Flow Distribution

Autor: Martin Siegemund, Sandra Annaheim, Jasper van Bommel, Mat van Iterson, Wolfgang Studer, Alexandre Mebazaa, Michiel E. Stegenga, Can Ince

Publikováno v: Anesthesia and analgesia, 111(2), 345-353. Lippincott Williams and Wilkins
Anesthesia & Analgesia, 111(2), 345-353. Lippincott Williams & Wilkins

BACKGROUND: In this study, we tested the hypothesis that aortic cross-clamping (ACC) and reperfusion cause distributive alterations of oxygenation and perfusion in the microcirculation of the gut and kidneys despite normal systemic hemodynamics and o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec738374e3f2135c9868e6abcd34c6a7
https://doi.org/10.1213/ane.0b013e3181e4255f

Leptin and host defense against Gram-positive and Gram-negative pneumonia in mice

Autor: Sandrine Florquin, Catharina W. Wieland, Michiel E. Stegenga, Giamila Fantuzzi, Tom van der Poll

Publikováno v: Shock (Augusta, Ga.), 25(4), 414-419. Lippincott Williams and Wilkins

Leptin is a pleiotrophic protein mainly produced by adipocytes that has been implicated as a link between nutritional status and immune function. Severe bacterial infection is associated with elevated plasma levels of leptin. To determine the role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3d70c0ada647d458fe1e15b0dc9c696
https://doi.org/10.1097/01.shk.0000209524.12873.da

Klinefelter syndrome associated myoclonus

Autor: Anne-Fleur van Rootselaar, A. W. G. Buijink, Michiel E. Stegenga, A. Meissner, Johannes H. T. M. Koelman

Publikováno v: Parkinsonism & related disorders, 20(11), 1315-1316. Elsevier BV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3110074ba967c32ab7055ace73ab0f6
https://doi.org/10.1016/j.parkreldis.2014.09.012

Early endotoxemia increases peripheral and hepatic insulin sensitivity in healthy humans

Autor: Michiel E. Stegenga, Mariëtte T. Ackermans, Hans P. Sauerwein, Michael W.T. Tanck, Saskia N. van der Crabben, Regje M. E. Blümer, Mireille J. Serlie, Tom van der Poll, Erik Endert

Publikováno v: Journal of Clinical Endocrinology & Metabolism, 94(2), 463-8. Oxford University Press
Journal of clinical endocrinology and metabolism, 94(2), 463-468. The Endocrine Society

CONTEXT: Sepsis-induced hypoglycemia is a well known, but rare, event of unknown origin. OBJECTIVE: The aim of the study was to obtain insight into the mechanism of sepsis-induced hypoglycemia, focusing on glucose kinetics and insulin sensitivity mea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ffb9ea1aa56befc921bb84ff3f6943
https://pubmed.ncbi.nlm.nih.gov/19193915

Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia

Autor: Joost C. M. Meijers, Hans P. Sauerwein, Regje M. E. Blümer, Mireille J. Serlie, Saskia N. van der Crabben, Michael W.T. Tanck, Michiel E. Stegenga, Marcel Levi, Tom van der Poll

Publikováno v: Blood, 112(1), 82-89. American Society of Hematology

Type 2 diabetes is associated with altered immune and hemostatic responses. We investigated the selective effects of hyperglycemia and hyperinsulinemia on innate immune, coagulation, and fibrinolytic responses during systemic inflammation. Twenty-fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acae5eee469f6e165538a17e79e7038f
https://pubmed.ncbi.nlm.nih.gov/18574036