Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Michiaki Matsuda"'
Publikováno v:
Rinsho Shinkeigaku. 57:759-763
We describe the case of a 90-year-old woman who was hospitalized in July 2016 and subsequently experienced a sudden decline in consciousness level resulting in a state of deep coma. Involuntary movements were not observed, and bilateral Babinski sign
Effects of antihistamines, ebastine and terfenadine, on electrocardiogram in conscious dogs and cats
Autor:
Katsuyoshi Nakatsuji, Yoshihide Kii, Michiaki Matsuda, Masafumi Yabuuchi, Tsugutaka Ito, Isamu Nose
Publikováno v:
Drug Development Research. 58:209-217
The purpose of this study was to evaluate the effects of ebastine and terfenadine on the electrocardiogram of conscious dogs and cats. In dogs, terfenadine at oral doses of 30 mg/kg twice a day for 7 days prolonged the electrocardiographic QT interva
Autor:
Sadao Komemushi, Yasuyuki Mizuki, Hidetada Sasaki, Hiroyuki Arai, Michiko Kano, Masatoshi Itoh, Masaaki Tagawa, Takehiko Watanabe, Toshihiko Fujii, Michiaki Matsuda, Makoto Higuchi, Kazuhiko Yanai, Nobuyuki Okamura
Publikováno v:
British Journal of Clinical Pharmacology. 53:296-304
Aims It has been widely recognized that classical antihistamines induce sedation as an adverse effect, while second-generation antihistamines have few if any sedative effects. In order to evaluate the sedative properties of ebastine, a second-generat
Autor:
Michiaki Matsuda, Masatoshi Itoh, Hiroyuki Arai, Michiko Kano, Tatsuo Ido, Ren Iwata, Hidetada Sasaki, Kazuhiko Yanai, Nobuyuki Okamura, Toshihiko Fujii, Masaaki Tagawa, Yasuyuki Mizuki, Sadao Komemushi, Makoto Higuchi, Takehiko Watanabe
Publikováno v:
British Journal of Clinical Pharmacology. 52:501-509
Aims Sedation induced by antihistamines is widely recognized to be caused by their penetration through the blood-brain-barrier and the consequent occupation of brain histamine H 1 -receptors. We previously studied the mechanism of sedation caused by
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 757:173-179
Ebastine (CAS 90729-43-4) is an antiallergic agent which selectively and potently blocks histamine H1-receptors in vivo. A simple and sensitive high-performance liquid chromatography (HPLC) method is described for the simultaneous determination of eb
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 15:1449-1456
AD-5423, 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[ b ]pyridine, is a novel anti-psychotic agent. In order to investigate the pharmacokinetics of AD-5423, a simple and sensitive high-performance liquid chromatograph
Autor:
Satoshi Matsumoto, Michiaki Matsuda, Masashi Mise, Seiji Yadera, Takanori Hashizume, Toshihiko Fujii, Yoshiaki Terauchi
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 32(2)
5-(3-methoxyphenyl)-3-(5-methyl-1,2,4-oxadiazol-3-yl)-2-oxo-1,2-dihydro-1,6-naphthyridine (AC-3933) is a novel cognitive enhancer with central benzodiazepine receptor partial inverse agonistic activity. AC-3933 is predominantly metabolized to hydroxy
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 776(2)
A convenient liquid chromatographic–single quadrupole mass spectrometric (LC–MS) method was developed and validated for the determination of chlorpheniramine maleate (INN name: chlorphenamine) in human plasma. The method had advantages of a singl
Autor:
Naomi Shibata, Isao Tomita, Yoshiyuki Nakamura, Takeshi Honma, Yukihiko Hara, Tsutomu Warashina, Michiaki Matsuda, Tadataka Noro
Publikováno v:
Plant Polyphenols 2 ISBN: 9780306462184
Much attention has been focused on the primary prevention of cancer using functional ingredients of edible plants.1 The components of tea leaves (Camellia sinensis), particularly green tea catechins, are known to be potent cancer chemopreventive agen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57993f9b8a39a99fc3ab403ec003f809
https://doi.org/10.1007/978-1-4615-4139-4_35
https://doi.org/10.1007/978-1-4615-4139-4_35
Autor:
Yoshiyuki Nakamura, Ichiro Kawase, Isao Tomita, Michiaki Matsuda, Seiji Harada, Takeshi Honma
Publikováno v:
Food Factors for Cancer Prevention ISBN: 9784431670193
Our attention has focused on the primary prevention of cancer using functional ingredients of edible plants. Here we report a new antitumor-promoting component, tea aqueous nondialysates (TNDs), and discuss the modes of action. TNDs were prepared fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ff6b1c3b05376368aed29bb0f0e7054
https://doi.org/10.1007/978-4-431-67017-9_27
https://doi.org/10.1007/978-4-431-67017-9_27