CAR-MEDIATED TARGETING OF NK CELLS OVERCOMES TUMOR IMMUNE ESCAPE CAUSED BY ICAM-1 DOWNREGULATION

Autor: Eitler, J., Rackwitz, W., Wotschel, N., Gudipati, V., Shankar, N. Murali, Sidorenkova, A., Huppa, J.B., Montero, P.O., Opitz, C., Künzel, S.R., Michen, S., Temme, A., Loureiro, L., Feldmann, A., Bachmann, M., Boissel, L., Klingemann, H.G., Wels, W.S., Tonn, T.

Publikováno v: In Cytotherapy June 2024 26(6) Supplement:S165-S165

Allogeneic NKG2C-positive NK cells for immunotherapy of glioblastoma multiforme

Autor: Murad, S, Michen, S, Becker, A, Sagerer, A, Füssel, M, Schackert, G, Momburg, F, Temme, A

Publikováno v: 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; 20210606-20210609; sine loco [digital]; DOCV291 /20210604/

Objective: NKG2C-positive natural killer (NK) cells represents a small NK cell subset, which is found in higher frequency in human cytomegalovirus (HCMV) seropositive patients. NKG2C+ NK cells can recognize target cells displaying HLA-E loaded with i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0aaa9712af628b159bf2695558b862e

A novel ex vivo expansion protocol using feeder cells for efficient production of GBM-reactive NKG2C-positive NK cell subsets

Autor: Becker, A, Murad, S, Michen, S, Schackert, G, Temme, A

Publikováno v: 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; 20200621-20200624; sine loco [digital]; DOCP115 /20200626/

Objective: Natural Killer (NK) cells have proven to be a promising candidate for the immunotherapy of tumours. As NK cells have a different cytokine-production profile compared to T cells, they do not bear the risk of inducing cytokine linked adverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5b64c2975b5b0eb8bb9f71c0a902cf

Impact of p53 on differential immunogenic stress responses of AZD1152-HQPA-treated polyploid glioma cells

Autor: Michen, S, Wiedemuth, R, Schackert, G, Temme, A

Publikováno v: 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS); 20160612-20160615; Frankfurt am Main; DOCP 011 /20160608/

Objective: The “Chromosomal Passenger Complex” (CPC) is one of the key regulators of cell division involved in the coordination of chromosomal and cytoskeletal events. The enzymatically active member of the complex is the Aurora B kinase which cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1fae7c926f3fc07821d0fc3b79c9a55

Targeting PSCA-positive tumor cells using a novel natural killer cell chimeric antigen receptor consisting of NKp46 and alphaPSCA

Autor: Michen, S, Schackert, G, Temme, A

Publikováno v: 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20140511-20140514; Dresden; DOCP 050 /20140513/

Objective: NK cells represent an important component of the innate immune system and are characterized by simultaneous expression of various inhibitory and activating receptors. They have been emerging as new effectors for immunotherapy of cancer. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f614c37a4fb7483cbefe01aec402875