Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Michelle Zakson-Aiken"'
Autor:
Michelle Zakson-Aiken, John G. Ondeyka, Michael A. Goetz, Arelene M. Dahl‐Roshak, Jan S. Tkacz, Sheo B. Singh, Deborah L. Zink, Wesley L. Shoop
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:2941-2944
During the re-isolation of the lead compound nodulisporic acid A ( 1a ) and targeted chemical screening for related compounds, we discovered a series of 1′-deoxy congeners named herein nodulisporic acids B ( 1b ), B 1 ( 2b ), and B 2 ( 3b ). In com
Autor:
Peter T. Meinke, Dennis M. Schmatz, L.M. Gregory, Steven L. Colletti, Prasun K. Chakravarty, Steve Salva, Matthew J. Wyvratt, Wesley L. Shoop, Michelle B. Ayer, Chunshi Li, Thomas L. Shih, Michelle Zakson-Aiken, Dong Ok, Michael H. Fisher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1751-1754
A series of new, diene-modified nodulisporic acid analogues ( 2 ) bearing diverse functionality at the 3″- and 4″-sites was efficiently prepared from the 3″-aldehyde 3 . Biological evaluation of these synthetic nodulisporic acid analogues for s
Publikováno v:
Veterinary Parasitology. 104:257-264
Probe studies were performed to determine if the cat flea (Ctenocephalides felis), the most common ectoparasite of companion animals, will feed on laboratory mice and, if so, to incorporate this into a small animal assay to detect systemically active
Autor:
Peter T. Meinke, Lynn M. Warmke, Steven L. Colletti, Michael H. Fisher, Michelle Zakson-Aiken, James V. Pivnichny, Karen Owens, Dennis M. Schmatz, Wesley L. Shoop, Matthew J. Wyvratt, Pierre deMontigny, Richard A. Berger
Publikováno v:
Organic Letters. 3:3715-3718
[reaction--see text] The semisynthetic conversion of nodulisporic acid A (1) into a set of three heterocyclic side chain derivatives provided compounds, highlighted by 6, with an improved spectrum of ectoparasiticidal activity and pharmacokinetic pro
Autor:
Dennis M. Schmatz, Steven L. Colletti, Julie Lim, Peter T. Meinke, Lynn M. Warmke, Wesley L. Shoop, Steve Salva, Thomas L. Shih, Matthew J. Wyvratt, Michelle B. Ayer, Chunshi Li, Michelle Zakson-Aiken, Dong Ok, Michael H. Fisher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2371-2374
Medicinal chemistry efforts were initiated to identify the key constituents of the nodulisporic acid A (1) pharmacophore that are integral to its potent insecticidal activity. New semisynthetic derivatives delineated 1 into 'permissive' and 'nonpermi
Publikováno v:
Journal of Medical Entomology. 37:571-574
Larvae of the cat flea, Ctenocephalides felis (Bouché), are the target of numerous growth regulators. This study explores the development of an assay that tests the susceptibility of cat flea larvae to a wide range of compounds. Different rearing me
Publikováno v:
Journal of Medical Entomology. 33:395-397
The objective of this study was to determine if there is evidence of parthenogenesis or autogenous reproduction in the cat flea, Ctenocephalides felis (Bouché). To examine parthenogenesis, 400 newly eclosed virgin female fleas were collected from a
Autor:
Prasun K. Chakravarty, Steven L. Colletti, Howard C. H. Kuo, Christine Snedden, Michelle B. Ayer, L.M. Gregory, Michael H. Fisher, Wesley L. Shoop, Matthew J. Wyvratt, Michelle Zakson-Aiken, Peter T. Meinke, Thomas L. Shih, Dennis M. Schmatz, Sriram Tyagarajan
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(1)
Efficient routes to access the 2", 3", 4", and 6" registers of the nodulisporic acid (NsA) side chain are disclosed. A mild one-carbon, Ph(2)CdoublebondNCH(2)CtriplebondN mediated homologation of NsA's 3"-aldehyde permitted access to the 4"-register.
Autor:
Dennis M. Schmatz, Peter T. Meinke, Wesley L. Shoop, Matthew J. Wyvratt, B. Pikounis, L.M. Gregory, James V. Pivnichny, Michelle Zakson-Aiken, B.F. Michael, M. H. Fisher
Publikováno v:
The Journal of parasitology. 87(5)
Nodulisporic acid A (NSA) has been shown previously to be safe in dogs and to deliver90% flea control for 4 days following a single oral administration. Three newly prepared nodulisporamide derivatives were subsequently identified from an artificial
Publikováno v:
Journal of medical entomology. 38(4)
Ivermectin has potent systemic activity against numerous species of nematodes and arthropods, but there are some important species in these two groups, such as the cat flea, Ctenocephalides felis (Bouche), that appear to be refractory to it. In an ef