Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michelle Y. H. Lai"'
Autor:
David J. Callis, Margaret A. Brimble, Nicholas S. Trotter, Paul W. R. Harris, Victoria J. Muir, Michelle Y. H. Lai
Publikováno v:
Tetrahedron. 61:10018-10035
The synthesis of ten proline-modified analogues of the neuroprotective tripeptide GPE is described. Five of the analogues incorporate a proline residue with a hydrophobic group at C-2 and two further analogues have this side chain locked into a spiro
Autor:
Frank Sieg, Michelle Y. H. Lai, Paul W. R. Harris, David J. Callis, Mark S. Levi, Margaret A. Brimble
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:533-548
The synthesis of 10 G*PE analogues, wherein the glycine residue has been modified, is described by coupling readily accessible dibenzyl-L-prolyl-L-glutamate 2 with various analogues of glycine. Pharmacological evaluation of the novel compounds was un
Publikováno v:
Org. Biomol. Chem.. 1:2084-2095
Homocoupling of naphthyl triflates 27, 16, 17 to the respective binaphthyls 28, 31 and 35 has been achieved in a one-pot procedure using bis(pinacolato)diboron and PdCl2(dppf). Use of potassium acetate as the base provides access to the initial napht
Publikováno v:
Organic & Biomolecular Chemistry. 1:4227
The synthesis of bis-furonaphthopyrans 12a and 12b, regioisomeric analogues of the dimeric pyranonaphthoquinone antibiotic crisamicin A 1 is described. The key intermediate 16 was prepared via a one-pot in situ Suzuki–Miyaura homocoupling of naphth