Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Michelle Wright Valderas"'
Autor:
Gloria S. Sivko, Lisa MacDonald, Marianne M. Stanford, Michelle Wright Valderas, Leeladhar Sammatur, Jon O. Rayner, Bradley J. Berger, Genevieve Weir, Rajkannan Rajagopalan
Publikováno v:
npj Vaccines, Vol 4, Iss 1, Pp 1-9 (2019)
NPJ Vaccines
NPJ Vaccines
Anthrax is a serious biological threat caused by pulmonary exposure to aerosolized spores of Bacillus anthracis. Biothrax® (anthrax vaccine adsorbed (AVA)) is the only Food and Drug Administration-licensed vaccine and requires five administrations o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3af29454d87e7a4569d6f34d161bbc
http://link.springer.com/article/10.1038/s41541-019-0102-z
http://link.springer.com/article/10.1038/s41541-019-0102-z
Autor:
Rebecca A. Duncan-Decocq, Patricia A. Clinkenbeard, Kimberly D. Hill, Nicole L. Clarkson, William W. Barrow, Michelle Wright Valderas, Kenneth D. Clinkenbeard, Christina R. Bourne, Esther W. Barrow, Rachel F. Perteet, Philip C. Bourne
Publikováno v:
SLAS Discovery. 17:946-956
One of the objectives of the National Institutes of Allergy and Infectious Diseases (NIAID) Biodefense Program is to identify or develop broad-spectrum antimicrobials for use against bioterrorism pathogens and emerging infectious agents. As a part of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70d3da963dd9b527159d2992301037c
https://doi.org/10.1177/1087057112448216
https://doi.org/10.1177/1087057112448216
Autor:
Timothy D. Brown, Daniel W. Martin, R. Martin Roop, Evan A. Menscher, Colin S. Burns, Michelle Wright Valderas, Jennifer M. Gaines, James T. Paulley, Eric S. Anderson
Publikováno v:
Infection and Immunity. 77:3466-3474
The gene designated BAB1_1460 in the Brucella abortus 2308 genome sequence is predicted to encode the manganese transporter MntH. Phenotypic analysis of an isogenic mntH mutant indicates that MntH is the sole high-affinity manganese transporter in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f43d492d89191a8912e1bdb162670227
https://doi.org/10.1128/iai.00444-09
https://doi.org/10.1128/iai.00444-09
Publikováno v:
Microbial Drug Resistance. 13:11-20
Natural resistance of field strains of Bacillus anthracis to drugs from the sulfonamide class of antimicrobials that act by inhibiting dihydropteroate synthase (DHPS) has been reported. Though the structure of B. anthracis DHPS has been determined, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7ccf645bd67ea49247e5754f3b56a9
https://doi.org/10.1089/mdr.2006.9992
https://doi.org/10.1089/mdr.2006.9992
Autor:
Rosemarie B. Alcantara, Michelle Wright Valderas, Richard D. A. Read, Timothy D. Brown, R. Martin Roop
Publikováno v:
Infection and Immunity. 72:4911-4917
Brucella abortus 2308 derivatives with mini-Tn 5 insertions in purE , purL , and purD display significant attenuation in the BALB/c mouse model, while isogenic mutants with mini-Tn 5 insertions in pheA , trpB , and dagA display little or no attenuati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0ac1721182eb1ba38ead9a688c3a88
https://doi.org/10.1128/iai.72.8.4911-4917.2004
https://doi.org/10.1128/iai.72.8.4911-4917.2004
Publikováno v:
Molecular Microbiology. 52:621-630
Members of the bacterial genus Brucella are facultative intracellular pathogens that reside predominantly within membrane-bound compartments within two host cell types, macrophages and placental trophoblasts. Within macrophages, the brucellae route t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48f4f1b185048ccefb617933aefcb77c
https://doi.org/10.1111/j.1365-2958.2004.04017.x
https://doi.org/10.1111/j.1365-2958.2004.04017.x
Dihydropteroate synthase (DHPS) catalyzes the formation of dihydropteroate and Mg-pyrophosphate from 6-hydroxymethyl-7,8-dihydropterin diphosphate and para-aminobenzoic acid. The Bacillus anthracis DHPS is intrinsically resistant to sulfonamides. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da46c7fcaff6a4c6de75401791b39e2
https://europepmc.org/articles/PMC2443783/
https://europepmc.org/articles/PMC2443783/
Publikováno v:
The Journal of antimicrobial chemotherapy. 61(1)
Background: Brucellae produce chronic and often lifelong infections in natural hosts. The persistent nature of these infections is predominantly due to the capacity of these bacteria to maintain intracellular residence in host macrophages. Successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76f000abbd74e1aa2929d6dfc20a49a
https://pubmed.ncbi.nlm.nih.gov/18024491
https://pubmed.ncbi.nlm.nih.gov/18024491
Publikováno v:
International journal of antimicrobial agents. 27(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf1be735a31caab9a1732825529fce3
https://pubmed.ncbi.nlm.nih.gov/16423510
https://pubmed.ncbi.nlm.nih.gov/16423510
Publikováno v:
Microorganisms and Bioterrorism ISBN: 9780387281568
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d17fff3dda9bac720b252e515e19e1f
https://doi.org/10.1007/0-387-28159-2_8
https://doi.org/10.1007/0-387-28159-2_8