Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Michelle Wehling-Henricks"'
Autor:
Eisuke Ochi, Alice Barrington, Michelle Wehling‐Henricks, Marcus Avila, Makoto Kuro‐o, James G. Tidball
Publikováno v:
Experimental Physiology, Vol 108, Iss 12, Pp 1531-1547 (2023)
Abstract Muscle growth is influenced by changes in the mechanical environment that affect the expression of genes that regulate myogenesis. We tested whether the hormone Klotho could influence the response of muscle to mechanical loading. Applying me
Externí odkaz:
https://doaj.org/article/36546edd455344778245b9c415eadd9e
Autor:
Yujiro Hayashi, David T. Asuzu, Michael R. Bardsley, Gabriella B. Gajdos, Sergiy M. Kvasha, David R. Linden, Rea A. Nagy, Siva Arumugam Saravanaperumal, Sabriya A. Syed, Yoshitaka Toyomasu, Huihuang Yan, Eduardo N. Chini, Simon J. Gibbons, Todd A. Kellogg, Khashayarsha Khazaie, Makoto Kuro-o, Jair Machado Espindola Netto, Mahendra Pal Singh, James G. Tidball, Michelle Wehling-Henricks, Gianrico Farrugia, Tamas Ordog
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 117-145 (2021)
Background & Aims: Gastric dysfunction in the elderly may cause reduced food intake, frailty, and increased mortality. The pacemaker and neuromodulator cells interstitial cells of Cajal (ICC) decline with age in humans, and their loss contributes to
Externí odkaz:
https://doaj.org/article/8b43f8672b2b4107aadaf0a158051895
Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy
Autor:
Steven S. Welc, Ivan Flores, Michelle Wehling-Henricks, Julian Ramos, Ying Wang, Carmen Bertoni, James G. Tidball
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
A number of therapeutic agents aimed at reducing pathology in Duchenne muscular dystrophy have been developed, but may have off-target effects when delivered systemically. Here, the authors express the therapeutic LIF transgene in leukocytes, and sho
Externí odkaz:
https://doaj.org/article/264ed254b4494b4a8400489886319488
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25071 (2011)
Survival of dystrophin/utrophin double-knockout (dko) mice was increased by muscle-specific expression of a neuronal nitric oxide synthase (nNOS) transgene. Dko mice expressing the transgene (nNOS TG+/dko) experienced delayed onset of mortality and i
Externí odkaz:
https://doaj.org/article/103b1afce9284e15b765e103a0aaa0ef
Autor:
Michelle Wehling-Henricks, Maria C Jordan, Tomomi Gotoh, Wayne W Grody, Kenneth P Roos, James G Tidball
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10763 (2010)
Duchenne muscular dystrophy (DMD) is the most common, lethal disease of childhood. One of 3500 new-born males suffers from this universally-lethal disease. Other than the use of corticosteroids, little is available to affect the relentless progress o
Externí odkaz:
https://doaj.org/article/7e04ad9a08524d3d8f1b56901185da90
Autor:
Ying Wang, Steven S. Welc, Michelle Wehling‐Henricks, Ying Kong, Connor Thomas, Enca Montecino‐Rodriguez, Kenneth Dorshkind, James G. Tidball
Publikováno v:
Aging Cell. 21
Intramuscular macrophages play key regulatory roles in determining the response of skeletal muscle to injury and disease. Recent investigations showed that the numbers and phenotype of intramuscular macrophages change during aging, suggesting that th
Autor:
Huihuang Yan, Khashayarsha Khazaie, Gianrico Farrugia, Sabriya A. Syed, Michelle Wehling-Henricks, Makoto Kuro-o, Simon J. Gibbons, Sergiy M. Kvasha, David T. Asuzu, Rea A. Nagy, Eduardo N. Chini, Mahendra Pal Singh, Yujiro Hayashi, David R. Linden, James G. Tidball, Gabriella B. Gajdos, Michael R. Bardsley, Jair Machado Espindola Netto, Siva Arumugam Saravanaperumal, Todd A. Kellogg, Tamas Ordog, Yoshitaka Toyomasu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 117-145 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology
Background & Aims Gastric dysfunction in the elderly may cause reduced food intake, frailty, and increased mortality. The pacemaker and neuromodulator cells interstitial cells of Cajal (ICC) decline with age in humans, and their loss contributes to g
Autor:
Cynthia M. McKee, Douglas J. Chapski, Michelle Wehling‐Henricks, Manuel Rosa‐Garrido, Makoto Kuro‐o, Thomas M. Vondriska, James G. Tidball
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36(3)
Modulating the number of muscle stems cells, called satellite cells, during early postnatal development produces long-term effects on muscle growth. We tested the hypothesis that high expression levels of the anti-aging protein Klotho in early postna
Publikováno v:
Human Molecular Genetics
Leukemia inhibitory factor (LIF) can influence development by increasing cell proliferation and inhibiting differentiation. Because of its potency for expanding stem cell populations, delivery of exogenous LIF to diseased tissue could have therapeuti
Targeting a therapeutic LIF transgene to muscle via the immune system ameliorates muscular dystrophy
Autor:
Michelle Wehling-Henricks, Julian Ramos, James G. Tidball, Ying Wang, Carmen Bertoni, Steven S. Welc, Ivan Flores
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Many potentially therapeutic molecules have been identified for treating Duchenne muscular dystrophy. However, targeting those molecules only to sites of active pathology is an obstacle to their clinical use. Because dystrophic muscles become extensi