Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michelle W. Wu"'
Autor:
Rakesh K. Jain, Arlene H. Sharpe, Meromit Singer, Ivy X. Chen, Debattama R. Sen, Kathleen Newcomer, Matthias Pinter, Kristen E. Pauken, Vikram R. Juneja, Michelle W. Wu, Kamila Naxerova
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Immune checkpoint blockade (ICB) has revolutionized treatment of many cancer types, but the majority of treated patients still do not respond to ICB. There is an urgent need to identify predictive biomarkers of response prior to or short
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da6e3ca2df2c438922031008acc0c9e
https://doi.org/10.1073/pnas.2002806117
https://doi.org/10.1073/pnas.2002806117
Autor:
Michelle W. Wu, Rakesh K. Jain, Jessica M. Posada, Neal I. Lindeman, Pichet Adstamongkonkul, Ivy X. Chen, Robert Langer, Peigen Huang, Vikash P. Chauhan, Mei Rosa Ng
Publikováno v:
Proceedings of the National Academy of Sciences. 116:4558-4566
Metastatic breast cancers (mBCs) are largely resistant to immune checkpoint blockade, but the mechanisms remain unclear. Primary breast cancers are characterized by a dense fibrotic stroma, which is considered immunosuppressive in multiple malignanci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0b2064b6b9dc1592c9810622c7b357
https://doi.org/10.1073/pnas.1815515116
https://doi.org/10.1073/pnas.1815515116
Autor:
Rakesh K. Jain, Yves Boucher, Peigen Huang, Michelle W. Wu, Ivy X. Chen, Kamila Naxerova, Vikash P. Chauhan, Daniel S. Kohane, Rong Tong, Mei Rosa Ng, Robert Langer, John D. Martin
Cancer-associated fibroblasts (CAFs) can either suppress or support T lymphocyte activity, suggesting that CAFs may be reprogrammable to an immunosupportive state. Angiotensin receptor blockers (ARBs) convert myofibroblast CAFs to a quiescent state,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f3fc8f7e797b2fd491e9b8def9dd79
https://europepmc.org/articles/PMC6561160/
https://europepmc.org/articles/PMC6561160/
Publikováno v:
Biochemical and Biophysical Research Communications. 444:562-567
Highlights: • We examine vascular stem cell function on microgrooved and micropost patterned polymer substrates. • 10 μm microgrooved surfaces significantly lower VSC proliferation but do not modulate calcified matrix deposition. • Micropost s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b8c990d88253b1afc18b20369007e3
https://doi.org/10.1016/j.bbrc.2014.01.100
https://doi.org/10.1016/j.bbrc.2014.01.100