Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Michelle W. Ma"'
Autor:
Julie K. Monda, Xuezhen Ge, Moritz Hunkeler, Katherine A. Donovan, Michelle W. Ma, Cyrus Y. Jin, Marilyn Leonard, Eric S. Fischer, Eric J. Bennett
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112496- (2023)
Summary: HUWE1 is a large, enigmatic HECT-domain ubiquitin ligase implicated in the regulation of diverse pathways, including DNA repair, apoptosis, and differentiation. How HUWE1 engages its structurally diverse substrates and how HUWE1 activity is
Externí odkaz:
https://doaj.org/article/adc1daeb5c5d4f8581b20f042daa562e
Autor:
Mathew R. Birnbaum, BS, Michelle W. Ma, MD, Sarah Fleisig, MD, Stuart Packer, MD, Bijal D. Amin, MD, Mark Jacobson, MD, Beth N. McLellan, MD
Publikováno v:
JAAD Case Reports, Vol 3, Iss 3, Pp 208-211 (2017)
Externí odkaz:
https://doaj.org/article/3492f72d68844f56a5e03ddc1f5de302
Autor:
Yen-Der Li, Michelle W. Ma, Muhammad Murtaza Hassan, Kedar Puvar, Mingxing Teng, Brittany Sandoval, Ryan Lumpkin, Scott B. Ficarro, Michelle Y. Wang, Shawn Xu, Brian J. Groendyke, Logan H. Sigua, Isidoro Tavares, Charles Zou, Jonathan M. Tsai, Paul M. Park, Hojong Yoon, Radosław P. Nowak, Jarrod A. Marto, Jun Qi, Katherine A. Donovan, Mikołaj Słabicki, Nathanael S. Gray, Eric S. Fischer, Benjamin L. Ebert
Publikováno v:
Cancer Research. 83:3424-3424
Molecular glue degraders have emerged as a powerful class of small-molecule therapeutics, as demonstrated by the clinical successes of thalidomide analogs in the treatment of hematological malignancies. These small molecules act by recruiting ubiquit
Autor:
Moritz Hunkeler, Julie K. Monda, Cyrus Y. Jin, Eric J. Bennett, Daan Overwijn, Eric S. Fischer, Michelle W. Ma
SummaryHECT ubiquitin ligases play essential roles in metazoan development and physiology. The HECT ligase HUWE1 is central to the cellular stress response by mediating degradation of key death or survival factors including Mcl1, p53, DDIT4, and Myc.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbda39072446342f07b11f360214597a
https://doi.org/10.1101/2020.08.19.257352
https://doi.org/10.1101/2020.08.19.257352
Autor:
Inchul You, Brian J. Groendyke, Mingxing Teng, Michael P. Agius, Jinhua Wang, Irene M. Ghobrial, SeongShick Ryu, Yunju Nam, Sara J. Buhrlage, Michelle W. Ma, Xiaoxi Liu, Taebo Sim, Yanke Liang, Dennis Dobrovolsky, Wanyi Hu, Mingfeng Hao, Eric S. Fischer, John M. Hatcher, Katherine A. Donovan, Nathanael S. Gray, Kun Shi, Hong Yue, Li Tan, Jianwei Che, Jonathan W. Bushman, Hanna Cho, Debabrata Bhunia, Sandip Sengupta, Fleur M. Ferguson, Nicholas A. Eleuteri, Zhengnian Li, Theresa D. Manz, Injae Shin, Baishan Jiang
Publikováno v:
Cell
Targeted protein degradation (TPD) refers to the use of small molecules to induce ubiquitin-dependent degradation of proteins. TPD is of interest in drug development, as it can address previously inaccessible targets. However, degrader discovery and
Autor:
Daan Overwijn, Cyrus Y. Jin, Eric S. Fischer, Eric J. Bennett, Michelle W. Ma, Moritz Hunkeler, Julie K. Monda
Publikováno v:
Molecular cell
SUMMARY HECT ubiquitin ligases play essential roles in metazoan development and physiology. The HECT ligase HUWE1 is central to the cellular stress response by mediating degradation of key death or survival factors, including Mcl1, p53, DDIT4, and My
Autor:
Beth N. McLellan, BS Mathew R. Birnbaum, Sarah B. Fleisig, Bijal Amin, Mark Jacobson, Stuart H. Packer, Michelle W. Ma
Publikováno v:
JAAD Case Reports, Vol 3, Iss 3, Pp 208-211 (2017)
JAAD Case Reports
JAAD Case Reports
Autor:
Mathew R, Birnbaum, Michelle W, Ma, Michael A, Casey, Bijal D, Amin, Mark, Jacobson, Haiying, Cheng, Beth N, McLellan
Publikováno v:
Journal of drugs in dermatology : JDD. 16(10)
Immunotherapy-induced vitiligo is an immune-related adverse event (irAE) observed in metastatic melanoma patients treated with immune checkpoint inhibitors that target the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death
Autor:
Michelle W. Ma, Iman Osman, Meng Qian, Yongzhao Shao, Daniel J. Lackaye, Nathaniel H. Fleming, Eva Hernando
Publikováno v:
Melanoma Research. 23:461-467
To better identify melanoma patients who are, at the time of primary melanoma diagnosis, at high risk of developing brain metastases, primary melanoma characteristics were examined as risk factors for brain metastasis development. In a study of two p
Autor:
Erica B. Friedman, Russell S. Berman, Richard L. Shapiro, Nina Bhardwaj, Farbod Darvishian, Ratna Medicherla, Iman Osman, Michelle W. Ma, Anna C. Pavlick, Meng Qian, Eleazar Vega-Saenz de Miera, Yongzhao Shao, Patrick A. Ott
Publikováno v:
Modern Pathology. 25:1000-1010
The sentinel lymph node is the initial site of metastasis. Downregulation of antitumor immunity has a role in nodal progression. Our objective was to investigate the relationship between immune modulation and sentinel lymph node positivity, correlati