Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Michelle Vanase-Frawley"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:415-419
Oxytocin (OT) is a peptide hormone agonist of the oxytocin receptor (OTR) that has been proposed as a therapeutic to treat a number of social and emotional disorders in addition to its current clinical use to induce labor and treat postpartum bleedin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd5d1b4c2f9aa6960e34665377115d6
https://doi.org/10.1016/j.bmcl.2017.12.027
https://doi.org/10.1016/j.bmcl.2017.12.027
Autor:
Eric S. Marr, Simone Sciabola, Robin T. Nelson, Anabella Villalobos, Xiaomin Chen, Stefan Doerr, Yaozhong Zou, Michelle Vanase-Frawley, Noelia Ferruz, Gianni De Fabritiis, Travis T. Wager, Xinjun Hou, Bethany L. Kormos
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-4 (2019)
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99456163627ecfc9f77045a007c6837
https://doi.org/10.1038/s41598-019-39694-1
https://doi.org/10.1038/s41598-019-39694-1
Autor:
Mark J. Majchrzak, Aarti Sawant-Basak, Christopher J. Schmidt, Nawshaba Nawreen, Thomas Allen Chappie, Rebecca E. O’Connor, Michelle Vanase-Frawley, Keith Dlugolenski, David Horton, David P. Nguyen, Bethany L. Kormos, Ramalakshmi Yegna Chandrasekaran, Travis T. Wager, Nancy C. Stratman, Elizabeth R. Dunn-Sims, Brian Samas, Andy N. Mead, Cathleen Hsu
Publikováno v:
ACS Chemical Neuroscience. 8:165-177
Dopamine receptor antagonism is a compelling molecular target for the treatment of a range of psychiatric disorders, including substance use disorders. From our corporate compound file, we identified a structurally unique D3 receptor (D3R) antagonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233def4cf409b94edafff8b7059d5f86
https://doi.org/10.1021/acschemneuro.6b00297
https://doi.org/10.1021/acschemneuro.6b00297
Autor:
Bruce N. Rogers, Simone Sciabola, Kari R. Fonseca, Natasha M. Kablaoui, David Gray, Michelle Vanase-Frawley, Guoyun Bai, Gilles H. Goetz, Allen J. Duplantier
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:3513-3520
Oxytocin (OT) is a peptide hormone agonist of the OT receptor (OTR) that plays an important role in social behaviors such as pair bonding, maternal bonding and trust. The pharmaceutical development of OT as an oral peptide therapeutic has been hinder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f865f06d5830b8a9ab10ad8278bb10
https://doi.org/10.1016/j.bmc.2016.05.062
https://doi.org/10.1016/j.bmc.2016.05.062
Autor:
Robin T. Nelson, Xinjun Hou, Bethany L. Kormos, Michelle Vanase-Frawley, Gianni De Fabritiis, Anabella Villalobos, Xiaomin Chen, Noelia Ferruz, Eric S. Marr, Travis T. Wager, Yaozhong Zou, Stefan Doerr, Simone Sciabola
Publikováno v:
Scientific Reports
Recercat. Dipósit de la Recerca de Catalunya
instname
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Recercat. Dipósit de la Recerca de Catalunya
instname
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
The recent increase in the number of X-ray crystal structures of G-protein coupled receptors (GPCRs) has been enabling for structure-based drug design (SBDD) efforts. These structures have revealed that GPCRs are highly dynamic macromolecules whose f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69abbdd6f75b6af22bacf11d8c85029e
http://europepmc.org/articles/PMC5772633
http://europepmc.org/articles/PMC5772633
Autor:
Christine P. Diggle, Nicholas J. Brandon, Khanh Q. Nguyen, Eamonn Sheridan, Manju A. Kurian, Joanne Ng, Veronica Reinhart, Michelle Vanase-Frawley, Melanie Allen, Saghira Malik Sharif, Christine A. Strick, Marius Politis, Eija Anttila, Tiago Reis Marques, Stacey J. Sukoff Rizzo, Alexander F. Markham, Karen Pysden, Erik I. Charych, Christopher M. Watson, Larry C. James, Laura Huilaja, Ian M. Carr, Jan-Philip Schülke, Christopher J. Schmidt, Juha O. Rinne, Kaisa Tasanen, Matti Kallioinen, Kati Alakurtti, Katariina Mankinen, Raija Sormunen, Somayyeh Fahiminiya, John F. Harms, Reetta Hinttala, Johanna Uusimaa, Oliver D. Howes, Päivi Vieira, Hannaleena Kokkonen, Jacek Majewski, Jarkko Johansson, Tiina Hurskainen, David T. Bonthron, Michael Popiolek
Deficits in the basal ganglia pathways modulating cortical motor activity underlie both Parkinson disease (PD) and Huntington disease (HD). Phosphodiesterase 10A (PDE10A) is enriched in the striatum, and animal data suggest that it is a key regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9408060ac2d9056541d39ae6f095b9
https://europepmc.org/articles/PMC4833436/
https://europepmc.org/articles/PMC4833436/
Autor:
Eric Feyfant, Natasha M. Kablaoui, Heather McInnes, Sarah M. Osgood, Michelle Vanase-Frawley, Ramin Darvari, Angela C. Doran, Kari R. Fonseca, Derek L. Buhl, Mark J. Majchrzak, Meera E. Modi
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
Oxytocin (OT) modulates the expression of social and emotional behaviors and consequently has been proposed as a pharmacologic treatment of psychiatric diseases, including autism spectrum disorders and schizophrenia; however, endogenous OT has a shor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b409ff47cab1e3155868ec1eb6f8f2
https://pubmed.ncbi.nlm.nih.gov/27217590
https://pubmed.ncbi.nlm.nih.gov/27217590
Autor:
Michael Aaron Brodney, R S Obach, Michelle Vanase-Frawley, Gregory W. Kauffman, Erik Alphie Lachapelle, Aarti Sawant-Basak
1.The first generation 5HT-4 partial agonist, 4-{4-[4-Tetrahydrofuran-3-yloxy)-benzo[d]isoxazol-3-yloxymethyl]-piperidin-1-ylmethyl}-tetrahydropyran-4-ol, PF-4995274 (TBPT), was metabolized to N-dealkylated (M1) and an unusual, cyclized oxazolidine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e0427ce3ce8afa0edb8491f587a6b4
Autor:
Alexandros Papanikolaou, Elaine E. Tseng, Noguchi Hirohide, Michael Aaron Brodney, Michelle Vanase-Frawley, Laura McDowell, Nobuaki Waizumi, Katherine Fisher, Aarti Sawant-Basak, Betty Pettersen, Elena M. Drummond, David M. Rubitski, Anne W. Schmidt, Kim Jonelle Stutzman-Engwall, David E. Johnson, Emily L. Hudson, Sarah Grimwood, Karen J. Coffman
Publikováno v:
Journal of Medicinal Chemistry. 55:9240-9254
The cognitive impairments observed in Alzheimer’s disease (AD) are in part a consequence of reduced acetylcholine (ACh) levels resulting from a loss of cholinergic neurons. Preclinically, serotonin 4 receptor (5-HT4) agonists are reported to modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d51b0b91e9707931c753f01d83b2c9f
https://doi.org/10.1021/jm300953p
https://doi.org/10.1021/jm300953p
Autor:
Robin J. Kleiman, Christopher J. Schmidt, Michael L. Corman, Patrick Robert Verhoest, Christopher John Helal, Jamison B. Tuttle, Shenpinq Liu, Michelle Vanase-Frawley, Frank S. Menniti, Spiros Liras, Karen J. Coffman, Kari R. Fonseca, Michelle Marie Claffey, Caroline Proulx-Lafrance, Xinjun Hou, Frederick R. Nelson
Publikováno v:
Journal of Medicinal Chemistry. 55:9045-9054
6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943) is a novel PDE9A inhibitor identified using parallel synthetic chemistry and structure-based drug de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc5bd4ed268fb9667a4ede29022a7fb5
https://doi.org/10.1021/jm3007799
https://doi.org/10.1021/jm3007799