Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Michelle V. Williams"'
Autor:
A. L. Doernte, Michelle V. Williams, Steven R. Tannenbaum, James G. Fox, Arlin B. Rogers, Steven A. Weinman, Yan Feng, Arkadiusz R. Raczynski, Stanley M. Lemon, Jose L. McFaline, Rebecca C. Fry, Jeannette Louise Allen Fiala, Elizabeth J. Theve, Peter C. Dedon, John M. Essigmann, David B. Schauer
Publikováno v:
Gut. 59:88-97
Background and aims: Hepatocellular carcinoma (HCC) frequently results from synergism between chemical and infectious liver carcinogens. Worldwide, the highest incidence of HCC is in regions endemic for the foodborne contaminant aflatoxin B1 (AFB1) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40718358e8f3f9dc29b047c344a0d43f
https://doi.org/10.1136/gut.2009.183749
https://doi.org/10.1136/gut.2009.183749
Publikováno v:
The Journal of Biological Chemistry
Lipoxygenases (LOs) convert polyunsaturated fatty acids into lipid hydroperoxides. Homolytic decomposition of lipid hydroperoxides gives rise to endogenous genotoxins such as 4-oxo-2(E)-nonenal, which cause the formation of mutagenic DNA adducts. Chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f19e5909c41c8ca50b67eea74744b92
https://doi.org/10.1074/jbc.m109.011841
https://doi.org/10.1074/jbc.m109.011841
Autor:
Stephan Steckelbroeck, David R. Bauman, Trevor M. Penning, Donna M. Peehl, Michelle V. Williams
Publikováno v:
Molecular Endocrinology. 20:444-458
Androgen-dependent prostate diseases initially require 5alpha-dihydrotestosterone (DHT) for growth. The DHT product 5alpha-androstane-3alpha,17beta-diol (3alpha-diol), is inactive at the androgen receptor (AR), but induces prostate growth, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121991e02804b348ee00dccdbc0bfdd6
https://doi.org/10.1210/me.2005-0287
https://doi.org/10.1210/me.2005-0287
Publikováno v:
Rapid Communications in Mass Spectrometry. 19:849-858
Reactive oxygen species convert the omega-6 polyunsaturated fatty acid arachidonic acid into 15-hydroperoxy-5,8,11,13-(Z,Z,ZE)-eicosatetraenoic acid (15-HPETE). Cyclooxygenases and lipoxygenases can also convert arachidonic acid into 15-HPETE. Vitami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ef8a41fe15d407e51502a6c3d2e19d
https://doi.org/10.1002/rcm.1854
https://doi.org/10.1002/rcm.1854
Autor:
Jeffrey P. Henderson, Michelle V. Williams, Jaeman Byun, Jay W. Heinecke, Dianne M. Mueller, Michael L. McCormick
Publikováno v:
Journal of Biological Chemistry. 276:7867-7875
The existence of interhalogen compounds was proposed more than a century ago, but no biological roles have been attributed to these highly oxidizing intermediates. In this study, we determined whether the peroxidases of white blood cells can generate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cb19370ccc10f2260f5a5e7b0622cfd
https://doi.org/10.1074/jbc.m005379200
https://doi.org/10.1074/jbc.m005379200
Autor:
Elizabeth M. Iffrig, Peter G. Slade, Alison Chiang, Steven R. Tannenbaum, John S. Wishnok, Michelle V. Williams
Publikováno v:
Prof. Tannenbaum via Howard Silver
During inflammation, the resulting oxidative stress can damage surrounding host tissue, forming protein-carbonyls. The SJL mouse is an experimental animal model used to assess in vivo toxicological responses to reactive oxygen and nitrogen species fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c04f95a36d89fd30155f46f276bbbe7
https://orcid.org/0000-0002-2325-552X
https://orcid.org/0000-0002-2325-552X
Autor:
Ian A. Blair, Angela Y. Wehr, Kannan Rangiah, Seon Hwa Lee, Michelle V. Williams, Raymond N. DuBois
Publikováno v:
Chemical research in toxicology. 20(11)
Rat intestinal epithelial cells that permanently express the cyclooxygenase-2 (COX-2) gene (RIES cells) were used to investigate COX-2-mediated arachidonic acid (AA) metabolism. A targeted chiral lipidomics approach was employed to quantify AA metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abed71cad90a8e4b84e01726a6c6930
https://pubmed.ncbi.nlm.nih.gov/17910482
https://pubmed.ncbi.nlm.nih.gov/17910482
Publikováno v:
Chemical research in toxicology. 20(5)
Polyunsaturated fatty acids can be converted to lipid hydroperoxides through nonenzymatic and enzymatic pathways. The prototypic omega-6 lipid hydroperoxide 13-hydroperoxy-octadecadienoic acid (13-HPODE) homolytically decomposes to form highly reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95761538f00ca6f071ab57c3a40c742e
https://pubmed.ncbi.nlm.nih.gov/17407328
https://pubmed.ncbi.nlm.nih.gov/17407328
Publikováno v:
The Journal of biological chemistry. 281(15)
Despite intensive research over the last two decades, there are still no specific markers of endogenous lipid hydroperoxide-mediated DNA damage. We recently demonstrated that heptanone-etheno-2'-deoxyguanosine adducts are formed in the DNA of rat int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0de526afcd576866bf6721af0e590b
https://pubmed.ncbi.nlm.nih.gov/16449227
https://pubmed.ncbi.nlm.nih.gov/16449227
Publikováno v:
The Journal of biological chemistry. 280(31)
Rat intestinal epithelial cells that express the cyclooxygenase-2 (COX-2) gene permanently (RIES cells) were used as a model of in vivo oxidative stress. A targeted lipidomics approach showed that 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) was t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6faf99bb964a2f5a16a47d86e9c94f5e
https://pubmed.ncbi.nlm.nih.gov/15964853
https://pubmed.ncbi.nlm.nih.gov/15964853