Zobrazeno 1 - 5
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pro vyhledávání: '"Michelle Tadano Lohr"'
Publikováno v:
Drug Metabolism and Disposition. 41:111-121
Ibuprofen is metabolized to chemically reactive acyl glucuronide and S-acyl-CoA metabolites that are proposed to transacylate glutathione (GSH) forming ibuprofen-S-acyl-GSH (I-SG) in vivo. Herein, we report the detection of novel metabolites of ibupr
Publikováno v:
Drug Metabolism and Disposition. 40:1515-1526
Carboxylic acid-containing nonsteroidal anti-inflammatory drugs (NSAIDs) can be metabolized to chemically reactive acyl glucuronide and/or S-acyl-CoA thioester metabolites capable of transacylating GSH. We investigated the metabolism of the NSAID mef
Autor:
George Tonn, Raju Subramanian, Bradley K. Wong, Simon Wong, Peter W. Fan, Michael G. Johnson, Michelle Tadano Lohr, Kirk Henne
Publikováno v:
Drug Metabolism and Disposition. 38:841-850
The 2-methyl substituted indole, 2MI [2-(4-(4-(2,4-dichlorophenylsulfonamido)-2-methyl-1 H -indol-5-yloxy)-3-methoxyphenyl)acetic acid] is a potent dual inhibitor of 1) chemoattractant receptor-homologous molecule expressed on T-helper type-2 cells a
Flunoxaprofen (FLX) is a chiral nonsteroidal anti-inflammatory drug that was withdrawn from clinical use because of concerns of potential hepatotoxicity. FLX undergoes highly stereoselective chiral inversion mediated through the FLX-S-acyl-CoA thioes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d09133fc0f400011101115555f4644cd
https://europepmc.org/articles/PMC2802421/
https://europepmc.org/articles/PMC2802421/
Autor:
Mark P. Grillo, Michelle Tadano Lohr
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 37(5)
Phenylacetic acid (PAA) represents a substructure of a class of nonsteroidal anti-inflammatory carboxylic acid-containing drugs capable of undergoing metabolic activation in the liver to acylcoenzyme A (CoA)- and/or acyl glucuronide-linked metabolite