Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Michelle T. Burstein"'
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 305-307 (2014)
A recent study revealed a mechanism of delaying aging in yeast by a natural compound which specifically impacts mitochondrial redox processes. In this mechanism, exogenously added lithocholic bile acid enters yeast cells, accumulates mainly in the in
Externí odkaz:
https://doaj.org/article/70023be167f84fa588693d623946613a
Autor:
Adam eBeach, Michelle T. Burstein, Vincent R. Richard, Anna eLeonov, Sean eLevy, Vladimir I. Titorenko
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
The peroxisome is an organelle that has long been known for its essential roles in oxidation of fatty acids, maintenance of reactive oxygen species (ROS) homeostasis and anaplerotic replenishment of tricarboxylic acid (TCA) cycle intermediates destin
Externí odkaz:
https://doaj.org/article/4b5bfda875034f548bc90857700d45e0
Autor:
Pavlo eKyryakov, Adam eBeach, Vincent R. Richard, Michelle T. Burstein, Anna eLeonov, Sean eLevy, Vladimir eTitorenko
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
The nonreducing disaccharide trehalose has been long considered only as a reserve carbohydrate. However, recent studies in yeast suggested that this osmolyte can protect cells and cellular proteins from oxidative damage elicited by exogenously added
Externí odkaz:
https://doaj.org/article/86b34844e65144c0a46639aa26466734
Autor:
Michelle T. Burstein, Adam Beach, Vincent R. Richard, Olivia Koupaki, Alejandra Gomez-Perez, Alexander A. Goldberg, Pavlo Kyryakov, Simon D. Bourque, Anastasia Glebov, Vladimir I. Titorenko
Publikováno v:
Dose-Response, Vol 10 (2012)
Various organisms ( i.e. , bacteria, fungi, plants and animals) within an ecosystem can synthesize and release into the environment certain longevity-extending small molecules. Here we hypothesize that these interspecies chemical signals can create x
Externí odkaz:
https://doaj.org/article/8b0ebcfa5eea451585ddfbcd81e7e19f
Autor:
Pavlo Kyryakov, Vincent R. Richard, Simon D. Bourque, Anna Leonov, Alejandra Gomez-Perez, Olivia Koupaki, Vladimir I. Titorenko, Adam Beach, Michelle T. Burstein, Anthony Arlia-Ciommo, Rachel Feldman
Publikováno v:
Oncotarget
A dietary regimen of caloric restriction delays aging in evolutionarily distant eukaryotes, including the budding yeast Saccharomyces cerevisiae. Here, we assessed how caloric restriction influences morphological, biochemical and cell biological prop
Autor:
Nimara Asbah, Alejandra Gomez-Perez, Forough Noohi, Michelle T. Burstein, Pavlo Kyryakov, Vladimir I. Titorenko, Tania Iouk
Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Vol 7 (2016)
Frontiers in Genetics, Vol 7 (2016)
Exogenously added lithocholic bile acid and some other bile acids slow down yeast chronological aging by eliciting a hormetic stress response and altering mitochondrial functionality. Unlike animals, yeast cells do not synthesize bile acids. We there
Autor:
Tatiana Iouk, Vincent R. Richard, Vladimir I. Titorenko, Simon D. Bourque, Anna Leonov, Olivia Koupaki, Mylène Juneau, Michelle T. Burstein, Adam Beach, Rachel Feldman
Publikováno v:
Aging (Albany NY)
Our studies revealed that lithocholic acid (LCA), a bile acid, is a potent anti-aging natural compound that in yeast cultured under longevity-extending caloric restriction (CR) conditions acts in synergy with CR to enable a significant further increa
Autor:
Forough Noohi, Adam Beach, Sean Levy, Anna Leonov, Alejandra Gomez-Perez, Vladimir I. Titorenko, Pavlo Kyryakov, Michelle T. Burstein, Olivia Koupaki, Vincent R. Richard
Publikováno v:
Cell Cycle. 11:3443-3462
Our studies revealed that LCA (lithocholic bile acid) extends yeast chronological lifespan if added to growth medium at the time of cell inoculation. We also demonstrated that longevity in chronologically aging yeast is programmed by the level of met
Autor:
Simon D. Bourque, Tatiana Boukh-Viner, Olivia Koupaki, Vladimir I. Titorenko, Anastasia Glebov, Christopher Gregg, Michelle T. Burstein, David Y. Thomas, Mylène Juneau, Ann M. English, Vincent R. Richard, Pavlo Kyryakov, Alexander A. Goldberg, Adam Beach
Publikováno v:
Aging (Albany NY)
In chronologically aging yeast, longevity can be extended by administering a caloric restriction (CR) diet or some small molecules. These life-extending interventions target the adaptable target of rapamycin (TOR) and cAMP/protein kinase A (cAMP/PKA)
Autor:
Sonia Rampersad, Vladimir I. Titorenko, Adam Beach, Michelle T. Burstein, Alexander A. Goldberg, Gayane Machkalyan, Christopher Gregg, Tatiana Boukh-Viner, Vincent R. Richard, Pavlo Kyryakov, Simon D. Bourque
Publikováno v:
Biochemical Society Transactions. 37:1050-1055
Growing evidence supports the view that LDs (lipid droplets) are dynamic organelles that can serve both as an intracellular signalling compartment and as an organizing platform orchestrating many vital processes in eukaryotic cells. It has become cle