Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Michelle Smeyne"'
Publikováno v:
Neuroscience. 295:23-38
Exercise reduces the risk of developing a number of neurological disorders and increases the efficiency of cellular energy production. However, overly strenuous exercise produces oxidative stress. Proper oxygenation is crucial for the health of all t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51c4ec7b7731a0c8df61f5585b3bfb5
https://doi.org/10.1016/j.neuroscience.2015.03.015
https://doi.org/10.1016/j.neuroscience.2015.03.015
Autor:
Richard J. Smeyne, Michelle Smeyne
Publikováno v:
Oxidative Stress and Redox Signalling in Parkinson’s Disease ISBN: 9781782621881
Glutathione (GSH) and thiol redox signalling are at the most basic level of cellular redox reactions and responses to oxidative stress. Oxidative stress plays a major role in the etiology of Parkinson’s disease. Reactive oxygen species (ROS) and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c71265868f1b1b843e868b590159224
https://doi.org/10.1039/9781782622888-00144
https://doi.org/10.1039/9781782622888-00144
Autor:
Richard J. Smeyne, Michelle Smeyne
Publikováno v:
Free Radical Biology and Medicine. 62:13-25
It has been established that oxidative stress, defined as the condition in which the sum of free radicals in a cell exceeds the antioxidant capacity of the cell, contributes to the pathogenesis of Parkinson disease. Glutathione is a ubiquitous thiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe35c35c4651bb789dbef3eeb5e5cd2
https://doi.org/10.1016/j.freeradbiomed.2013.05.001
https://doi.org/10.1016/j.freeradbiomed.2013.05.001
Publikováno v:
Glia. 52:144-152
Free radical damage has been shown to play a significant role in the pathogenesis of a number of neurodegenerative diseases including Parkinson's disease. One model of experimental parkinsonism is the loss of substantia nigra cells following administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba828fca2338286608ec9be3327459d
https://doi.org/10.1002/glia.20233
https://doi.org/10.1002/glia.20233
Autor:
Amar K. Pani, Jennifer L. McClaren, Richard J. Smeyne, Robert G. Webster, Ane Korff, David A. Boltz, Michelle Smeyne, Haeman Jang
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(5)
The A/VN/1203/04 strain of the H5N1 influenza virus is capable of infecting the CNS of mice and inducing a number of neurodegenerative pathologies. Here, we examined the effects of H5N1 on several pathological aspects affected in parkinsonism, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5086d00108b327e959c711ee9e219eb
https://pubmed.ncbi.nlm.nih.gov/22302798
https://pubmed.ncbi.nlm.nih.gov/22302798
Autor:
Brenda Pfeiffer, Ronald F. Pfeiffer, Ane Korff, Michelle Smeyne, Richard J. Smeyne, Mehmet Kocak
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by progressive loss of the pigmented dopaminergic (DA) neurons located in the substantia nigra pars compacta (SNpc) that results in a reduction in the number of its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a20852d92b106281cc69c68b90005ced
https://europepmc.org/articles/PMC3307132/
https://europepmc.org/articles/PMC3307132/
Autor:
Kennie R. Shepherd, Colin J. Henderson, Michelle Smeyne, Justin D. Boyd, Yun Jiao, Richard J. Smeyne, Roland Wolf, Brooks B. Pond, Matthew Hatler
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(6)
The cause of 95% of Parkinson's disease (PD) cases is unknown. It is hypothesized that PD arises from an interaction of free-radical-generating agents with an underlying genetic susceptibility to these compounds. Here we use the 1-methyl-4-phenyl-1,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8afa65a7dc1ba8d3f32e7faf633bffc0
https://pubmed.ncbi.nlm.nih.gov/17267597
https://pubmed.ncbi.nlm.nih.gov/17267597
Autor:
Dianne Kowal, Reinhardt Baudy, Doreen Chiu, Stephen Lin, John W. Olney, Michelle Smeyne, Lucy Sun, R. Suzanne Zukin, Rachelle Simon
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 310(2)
Two novel N-methyl-d-aspartate (NMDA) antagonists with unique chemical structures, EAA-090 (2-[8,9-dioxo-2, 6-diazabicyclo[5.2.0]non-1(7)-en2-yl]ethylphosphonic acid) and EAB-318 (R-alpha-amino-5-chloro-1-(phosphonomethyl)-1H-benzimidazole-2-propanoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74570981ec664f8e980cab757ad67e3a
https://pubmed.ncbi.nlm.nih.gov/15075380
https://pubmed.ncbi.nlm.nih.gov/15075380
Autor:
Richard J. Smeyne, Michelle Smeyne
Publikováno v:
Brain research. Brain research protocols. 9(2)
One of the most prevalent degenerative disorders of the nervous system is Parkinson's disease. The etiology of this disease is for the most part unknown, although it is posited to arise from an interaction of genetic and environmental factors. Althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0789e2c75c5cb5b6160868cd9fc48b1
https://pubmed.ncbi.nlm.nih.gov/12034329
https://pubmed.ncbi.nlm.nih.gov/12034329
Publikováno v:
Glia. 34(2)
Parkinson's disease (PD) is a debilitating neurological disorder that strikes approximately 2% of people over age 50. Current hypotheses propose that the cause of PD is multifactorial, involving environmental agents and genetic predisposition. 1-Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7a1ccbaf870aab7d87490751263641
https://pubmed.ncbi.nlm.nih.gov/11307156
https://pubmed.ncbi.nlm.nih.gov/11307156