Zobrazeno 1 - 4
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pro vyhledávání: '"Michelle Searles"'
Publikováno v:
Journal of Applied Toxicology. 37:445-453
Inhibition of the human ether-a-go-go-related gene (hERG) K+ channel by drugs leads to QT prolongation on the electrocardiogram and can result in serious cardiac arrhythmia. For this reason, screening of drugs on hERG is mandatory during the drug dev
Autor:
Jonathan A. Fidler, Kuma Misra, Christopher M. Treleaven, Richard L. Sidman, Thomas J. Tamsett, Seng H. Cheng, James Dodge, Tatyana V. Taksir, Channa Bao, Lamya S. Shihabuddin, Michelle Searles
Publikováno v:
Proceedings of the National Academy of Sciences. 110:10812-10817
Metabolic dysfunction is an important modulator of disease course in amyotrophic lateral sclerosis (ALS). We report here that a familial mouse model (transgenic mice over-expressing the G93A mutation of the Cu/Zn superoxide dismutase 1 gene) of ALS e
Carbohydrate-Mediated Polyethylene Glycol Conjugation of TSH Improves Its Pharmacological Properties
Autor:
Kerry Culm-Merdek, Christian Braithwaite, Michelle Searles, Jonathan S. Kingsbury, Anna Park, Josephine Kyazike, John M. McPherson, James E. Stefano, Lihui Hou, Clark Pan, Ben Greene, Huawei Qiu, Denise M. Honey, Christine Zarazinski, Julie Bird
Publikováno v:
Endocrinology. 154:1373-1383
Thyrogen (thyrotropin alfa for injection), recombinant human TSH (rhTSH), has been successfully used to enhance diagnostic radioiodine scanning and thyroglobulin testing in the follow-up of patients with thyroid cancer and as an adjunctive treatment
Publikováno v:
Journal of applied toxicology : JAT. 37(4)
Inhibition of the human ether-a-go-go-related gene (hERG) K