Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Michelle Sclanders"'
Autor:
Anne Rigby, Sandrine Vessillier, David Baker, Gill Adams, Lorna Layward, Lisa Mullen, Alex Annenkov, Gayatri Mittal, Michelle Sclanders, Yuti Chernajovsky, David Gould
Publikováno v:
Expert Opinion on Drug Delivery. 11:101-110
The use of cytokines as therapeutic agents is important, given their potent biological effects. However, this very potency, coupled with the pleiotropic nature and short half-life of these molecules, has limited their therapeutic use. Strategies to i
Autor:
Gayatri Mittal, Lorna Layward, Sarah Al-Izki, Rewas Fatah, David Baker, Gill Adams, Alex Annenkov, Sandrine Vessillier, Chris Bolton, Yuti Chernajovsky, Julie Foster, Anne Rigby, Gareth Pryce, Hansjörg Hauser, Cristina Subang, Lisa Mullen, David Gould, Julia M Colston, Michelle Sclanders, Philippa Francis-West, Mario Köster
Publikováno v:
Expert opinion on drug delivery. 11(1)
Targeting cytokines to sites of disease has clear advantages because it increases their therapeutic index. We designed fusion proteins of the latent-associated peptide (LAP) derived from TGF-β with various cytokines via a matrix metalloproteinase (M
Autor:
Apostolos, Koutsokeras, Nirupam, Purkayastha, Nirupam, Purkayashta, Anne, Rigby, Maria C, Subang, Michelle, Sclanders, Sandrine, Vessillier, Lisa, Mullen, Yuti, Chernajovsky, David, Gould
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(1)
Gene therapy is a powerful approach to treat disease locally. However, if the therapeutic target is intracellular, the therapeutic will be effective only in the cells where the therapeutic gene is delivered. We have engineered a fusion protein contai