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pro vyhledávání: '"Michelle Schaper"'
Autor:
Michelle Schaper, Yves Alarie
Publikováno v:
Pathophysiology and Treatment of Inhalation Injuries ISBN: 9781003065838
Pathophysiology and Treatment of Inhalation Injuries
Pathophysiology and Treatment of Inhalation Injuries
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35bb1151dfc439850634a53dd1e46df6
https://doi.org/10.1201/9781003065838-3
https://doi.org/10.1201/9781003065838-3
Publikováno v:
Archives of Toxicology. 72:125-140
We used a database of 145 volatile organic chemicals for which the sensory irritation potency (RD50) has been reported in mice. Chemicals were first separated into two groups: nonreactive and reactive, using Ferguson's rule. This rule suggests that n
Publikováno v:
SAR and QSAR in Environmental Research. 5:151-165
This article describes the possibility of estimating whether or not a mixture of nonreactive volatile organic chemicals (NRVOC) is likely to elicit complaints of sensory irritation in humans. For this estimation we rely on: a) the sensory irritating
Publikováno v:
Archives of Toxicology. 70:195-201
A synthetic metalworking fluid, MWF "A", and its major components were evaluated using a previously developed mouse bioassay. This fluid and its components evoked sensory (S) and pulmonary (P) irritation in mice. For MWF "A" and each of its component
Publikováno v:
Archives of Toxicology. 69:671-676
Recently, the sensory and pulmonary irritating properties of ten metalworking fluids (MWF) were assessed using a mouse bioassay. Relative potency of the MWFs was estimated, but it was not possible to identify the component(s) responsible for the the
Publikováno v:
Archives of Toxicology. 68:332-337
Over the past 40 years, toxicologists and pharmacologists have used tables published by Weil for the determination of LD50 (or ED50) values and their associated 95% confidence intervals. With the advances in computer technology, it is now common for
Publikováno v:
Archives of Toxicology. 67:478-490
A system was developed for exposure of unanesthetized mice to airborne chemicals and for continuous measurement of their breathing pattern prior to, during and following exposure. By measuring inspiratory and expiratory airflows (VI and VE), and inte
Autor:
Gilbert J. Burckart, Robert J. Keenan, Michelle Schaper, Samuel A. Yousem, Andrew J. Duncan, Bartley P. Griffith, Robert D. Dowling, Yves Alarie, Marco A. Zenati
Publikováno v:
Transplantation. 53:20-24
Rejection remains a major obstacle to long-term success of pulmonary transplantation. Direct delivery of cyclosporine to lung allografts may produce better control of rejection by generating high intragraft concentrations of drug with decreased syste
Autor:
Michelle Schaper, Katherine Detwiler
Publikováno v:
Fundamental and Applied Toxicology. 16:309-319
Using a previously developed bioassay, the sensory and pulmonary irritating properties of a group of 10 aerosolized machining fluids were evaluated in mice. Single, 3-hr inhalation exposures were conducted with the fluids at exposure concentrations r
Autor:
D. Casarotto, S.A. Yousem, Griffith Bp, Marco A. Zenati, Andrew J. Duncan, Michelle Schaper, Gilbert J. Burckart
Publikováno v:
European Journal of Cardio-Thoracic Surgery. 5:266-272
The efficacy of local delivery of aerosol cyclosporine (CsA) for prevention of lung rejection was compared with the intramuscular route (IM) in a fully allogeneic rat model (BN/LEW) of lung transplantation (LTx). Control rats (group 1, n = 6) receive