Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Michelle S. Kuo"'
Autor:
Jinghai James Xu, James Butler, Wendy D. Cornell, Meiping Chang, Jagruti Patel, Darren Freeman, Michael McGlashen, Man Chang, Debbie Szalkowski, Sarah McQuay, Robin McEntire, Michelle S. Kuo
Publikováno v:
Drug Discovery Today. 21:826-835
External content sources such as MEDLINE(®), National Institutes of Health (NIH) grants and conference websites provide access to the latest breaking biomedical information, which can inform pharmaceutical and biotechnology company pipeline decision
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b6f429ef03588703d95985fa91d8be
https://doi.org/10.1016/j.drudis.2016.03.006
https://doi.org/10.1016/j.drudis.2016.03.006
Publikováno v:
Synthetic Communications. 37:1887-1897
Practical syntheses of 4‐fluoro‐2‐(methylthio)benzylamine 1 and the corresponding 2‐methylsulfonyl analog 2 are reported. The methylthio moiety was introduced regioselectively by two methods. In the first method, metallation of 4‐fluoro‐2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cba871bc41c1f6391d993ea9f2c74b05
https://doi.org/10.1080/00397910701319221
https://doi.org/10.1080/00397910701319221
Autor:
C. J. Woyden, Roger M. Freidinger, Mark G. Bock, Duane R. Reiss, Joseph M. Pawluczyk, Michelle S. Kuo, Amy G. Quigley, Douglas J. Pettibone, Maribeth T. Guidotti, E V Lis, D. S. Perlow, Peter D. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3081-3086
Structure-activity studies on the oxytocin antagonist 1 (L-371,257) have identified a new series of high affinity, receptor-selective OT antagonists in which the N-acetyl-4-piperidinyl ether terminus in 1 has been replaced with a 1-(aryl)ethoxy group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765c00dce9dedfe799c42f855a73f496
https://doi.org/10.1016/s0960-894x(98)00568-x
https://doi.org/10.1016/s0960-894x(98)00568-x
Autor:
Steven N. Gallicchio, James P. Guare, C. J. Woyden, Duane R. Reiss, Carl F. Homnick, Roger M. Freidinger, S Vickers, Michelle S. Kuo, E V Lis, Stuart R. Michelson, Douglas J. Pettibone, Peter D. Williams, Joseph M. Pawluczyk, Erb Jm, Doug W. Hobbs, Ian M. Bell, Rita A. Halpin, David J. Mathre, Maribeth T. Guidotti
Publikováno v:
Journal of Medicinal Chemistry. 41:2146-2163
The previously reported oxytocin antagonist L-371,257 (2) has been modified at its acetylpiperidine terminus to incorporate various pyridine N-oxide groups. This modification has led to the identification of compounds with improved pharmacokinetics a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74cfbae44800fb3afe7907b08d0fc3a
https://doi.org/10.1021/jm9800797
https://doi.org/10.1021/jm9800797
Autor:
A L A L Et Et, Michelle S. Kuo and
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84f52ad1d4ae998c7988b636d36e8dce
https://doi.org/10.1002/chin.199911149
https://doi.org/10.1002/chin.199911149
Publikováno v:
ChemInform. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d60ef2eb6bbc6ddb67238c242b906f
https://doi.org/10.1002/chin.200745081
https://doi.org/10.1002/chin.200745081
Autor:
Yvonne M. Leonard, Gregory Moyer, Wei Han, Jeffrey Y. Melamed, Nancy N. Tsou, Lixia Jin, H. Marie Moritz, Amanda R. Cortes, D. S. Perlow, William A. Schleif, Lori J. Gabryelski, Michelle S. Kuo, Marc V. Witmer, Melissa S. Egbertson, Matthew P. Braun, Wei Xu, Peter J. Felock, Steven D. Young, Matthew M. Zrada, Michael D. Miller, Mark Embrey, Kellem Kassahun, Audrey A. Wallace, Daria J. Hazuda, Joan D. Ellis, Kara A. Stillmock, Joseph P. Vacca
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(5)
A 1,6-naphthyridine inhibitor of HIV-1 integrase has been discovered with excellent inhibitory activity in cells, good pharmacokinetics, and an excellent ability to inhibit virus with mutant enzyme.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d2a6928c48f5b74c5ffc5fcc5aa82f
https://pubmed.ncbi.nlm.nih.gov/17194584
https://pubmed.ncbi.nlm.nih.gov/17194584
Autor:
Michelle R. Levy, K.J. Stauffer, Roger M. Freidinger, E V Lis, Mark G. Bock, Stuart R. Michelson, Douglas J. Pettibone, D. S. Perlow, Christopher A. Salvatore, Marlene A. Jacobson, B. E. Evans, Joseph M. Pawluczyk, Amy G. Quigley, C. J. Woyden, Maribeth T. Guidotti, Peter D. Williams, Michelle S. Kuo, Steven N. Gallicchio, Duane R. Reiss
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(9)
Structure-activity studies on the oxytocin antagonist 1 (L-371,257; Ki = 9.3 nM) have led to the identification of a related series of compounds containing an ortho-trifluoroethoxyphenylacetyl core which are orally bioavailable and have significantly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5060b712acd7d054079f1d505f8a7310
https://pubmed.ncbi.nlm.nih.gov/10340620
https://pubmed.ncbi.nlm.nih.gov/10340620