Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Michelle S Prew"'
Autor:
Andrea Schmidts, Leah C Marsh, Ambike A Srivastava, Amanda A Bouffard, Angela C Boroughs, Rebecca C Larson, Felipe Bedoya, Bryan D Choi, Stefanie R Bailey, Mark B Leick, Sonika Vatsa, Michael C Kann, Michelle S Prew, Benjamin P Kleinstiver, J Keith Joung
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Adoptive cell therapy with chimeric antigen receptor T cells (CAR-T) has become a standard treatment for patients with certain aggressive B cell malignancies and holds promise to improve the care of patients suffering from numerous other c
Externí odkaz:
https://doaj.org/article/1383b25b9a8e4f49a0640c17e9556951
Autor:
Michelle S. Prew, Utsarga Adhikary, Dong Wook Choi, Erika P. Portero, Joao A. Paulo, Pruthvi Gowda, Amit Budhraja, Joseph T. Opferman, Steven P. Gygi, Nika N. Danial, Loren D. Walensky
Publikováno v:
Cell Reports, Vol 41, Iss 1, Pp 111445- (2022)
Summary: MCL-1 is an anti-apoptotic BCL-2 family protein essential for survival of diverse cell types and is a major driver of cancer and chemoresistance. The mechanistic basis for the oncogenic supremacy of MCL-1 among its anti-apoptotic homologs is
Externí odkaz:
https://doaj.org/article/cc4932558c9943c9aa40dd9178059850
Autor:
Noah B. Bloch, Thomas E. Wales, Michelle S. Prew, Hannah R. Levy, John R. Engen, Loren D. Walensky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The pro-apoptotic BAX protein is a monomer under homeostatic conditions and, in response to stress, transforms into oligomers that induce apoptosis. Here, the authors characterize structural features of BAX that individually stabilize the monomer whi
Externí odkaz:
https://doaj.org/article/6094840e65e043afbdbb1d1b24daacd6
Autor:
Rachel M. Guerra, Gregory H. Bird, Edward P. Harvey, Neekesh V. Dharia, Kyle J. Korshavn, Michelle S. Prew, Kimberly Stegmaier, Loren D. Walensky
Publikováno v:
Cell Reports, Vol 24, Iss 13, Pp 3393-3403.e5 (2018)
Summary: Cancer cells overexpress a diversity of anti-apoptotic BCL-2 family proteins, such as BCL-2, MCL-1, and BFL-1/A1, to enforce cellular immortality. Thus, intensive drug development efforts have focused on targeting this class of oncogenic pro
Externí odkaz:
https://doaj.org/article/241d557caaf245f2beda033f71b52f95
Autor:
Michelle S. Prew, Christina M. Camara, Thomas Botzanowski, Jamie A. Moroco, Noah B. Bloch, Hannah R. Levy, Hyuk-Soo Seo, Sirano Dhe-Paganon, Gregory H. Bird, Henry D. Herce, Micah A. Gygi, Silvia Escudero, Thomas E. Wales, John R. Engen, Loren D. Walensky
Publikováno v:
Nature Communications. 13
Very long-chain acyl-CoA dehydrogenase (VLCAD) is an inner mitochondrial membrane enzyme that catalyzes the first and rate-limiting step of long-chain fatty acid oxidation. Point mutations in human VLCAD can produce an inborn error of metabolism call
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2293d635608ae6a28d6a59b2ffa0f12
https://doi.org/10.1038/s41467-022-31466-2
https://doi.org/10.1038/s41467-022-31466-2
Autor:
Loren D. Walensky, Ann M. Cathcart, Henry D. Herce, Tun Oo, Thomas E. Wales, John R. Engen, Susan Lee, Michelle S. Prew, Utsarga Adhikary, Zachary J. Hauseman, Gregory H. Bird, Catherine E. Newman, Edward P. Harvey
Publikováno v:
Nature chemical biology
The ubiquitin-proteasome system (UPS) is a highly regulated protein disposal process critical to cell survival. Inhibiting the pathway induces proteotoxic stress and can be an effective cancer treatment. The therapeutic window observed upon proteasom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d865b2ee1252e475ea646a5adcf4fa
https://doi.org/10.1038/s41589-020-0625-7
https://doi.org/10.1038/s41589-020-0625-7
Autor:
Michelle S, Prew, Christina M, Camara, Thomas, Botzanowski, Jamie A, Moroco, Noah B, Bloch, Hannah R, Levy, Hyuk-Soo, Seo, Sirano, Dhe-Paganon, Gregory H, Bird, Henry D, Herce, Micah A, Gygi, Silvia, Escudero, Thomas E, Wales, John R, Engen, Loren D, Walensky
Publikováno v:
Nature communications. 13(1)
Very long-chain acyl-CoA dehydrogenase (VLCAD) is an inner mitochondrial membrane enzyme that catalyzes the first and rate-limiting step of long-chain fatty acid oxidation. Point mutations in human VLCAD can produce an inborn error of metabolism call
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a93e95466fd4e43f2a1609195a31e203
https://pubmed.ncbi.nlm.nih.gov/35760926
https://pubmed.ncbi.nlm.nih.gov/35760926
Autor:
Thomas E. Wales, John R. Engen, Noah B. Bloch, Hannah R. Levy, Michelle S. Prew, Loren D. Walensky
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
BAX is a pro-apoptotic member of the BCL-2 family, which regulates the balance between cellular life and death. During homeostasis, BAX predominantly resides in the cytosol as a latent monomer but, in response to stress, transforms into an oligomeric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd7b77a3ae895528bd6f872222670e0
https://doi.org/10.1038/s41467-021-25200-7
https://doi.org/10.1038/s41467-021-25200-7
Autor:
Amanda A. Bouffard, Michelle S. Prew, Rebecca C. Larson, Felipe Bedoya, Leah C Marsh, J. Keith Joung, Mark B. Leick, Marcela V. Maus, Matthew J. Frigault, Michael Kann, Angela C. Boroughs, Sonika Vatsa, Bryan D. Choi, Stefanie R. Bailey, Irene Scarfò, Andrea Schmidts, Ambike A Srivastava, Benjamin P. Kleinstiver
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
BackgroundAdoptive cell therapy with chimeric antigen receptor T cells (CAR-T) has become a standard treatment for patients with certain aggressive B cell malignancies and holds promise to improve the care of patients suffering from numerous other ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf10bd05da561409e742c0a32d443750
http://europepmc.org/articles/PMC7477986
http://europepmc.org/articles/PMC7477986
Autor:
Shengdar Q. Tsai, J. Keith Joung, Vikram Pattanayak, Michelle S. Prew, Nhu T. Nguyen, Zongli Zheng, Benjamin P. Kleinstiver
Publikováno v:
Nature. 529:490-495
CRISPR-Cas9 nucleases are widely used for genome editing but can induce unwanted off-target mutations. Existing strategies for reducing genome-wide off-target effects of the widely used Streptococcus pyogenes Cas9 (SpCas9) are imperfect, possessing o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82eff09bf78aa9ec2081ceabcfef183
https://doi.org/10.1038/nature16526
https://doi.org/10.1038/nature16526