Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Michelle S Longworth"'
Condensin II and GAIT complexes cooperate to restrict LINE-1 retrotransposition in epithelial cells.
Autor:
Jacqueline R Ward, Kommireddy Vasu, Emily Deutschman, Dalia Halawani, Peter A Larson, Dongmei Zhang, Belinda Willard, Paul L Fox, John V Moran, Michelle S Longworth
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007051 (2017)
LINE-1 (L1) retrotransposons can mobilize (retrotranspose) within the human genome, and mutagenic de novo L1 insertions can lead to human diseases, including cancers. As a result, cells are actively engaged in preventing L1 retrotransposition. This w
Externí odkaz:
https://doaj.org/article/b6c172ada2f4465b888935d27b1d06d7
Autor:
Rashmi Bharti, Goutam Dey, Debjit Khan, Alex Myers, Olivia G. Huffman, Caner Saygin, Chad Braley, Elliott Richards, Naseer Sangwan, Belinda Willard, Justin D. Lathia, Paul L. Fox, Feng Lin, Babal Kant Jha, J. Mark Brown, Jennifer S. Yu, Mohammed Dwidar, Amy Joehlin-Price, Roberto Vargas, Chad M. Michener, Michelle S. Longworth, Ofer Reizes
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-23 (2024)
Abstract Background Platinum resistance is the primary cause of poor survival in ovarian cancer (OC) patients. Targeted therapies and biomarkers of chemoresistance are critical for the treatment of OC patients. Our previous studies identified cell su
Externí odkaz:
https://doaj.org/article/adfec356b7014a638df6edb322f5b4fb
Autor:
Bert I. Crawford, Mary Jo Talley, Joshua Russman, James Riddle, Sabrina Torres, Troy Williams, Michelle S. Longworth
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Neural stem and progenitor cell (NSPC) maintenance is essential for ensuring that organisms are born with proper brain volumes and head sizes. Microcephaly is a disorder in which babies are born with significantly smaller head sizes and cort
Externí odkaz:
https://doaj.org/article/e89e55165178416f950ff9afb9b489d5
Autor:
Susana Lechuga, Armando Marino-Melendez, Austin Davis, Ajay Zalavadia, Afshin Khan, Michelle S. Longworth, Andrei I. Ivanov
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The actin cytoskeleton regulates the integrity and repair of epithelial barriers by mediating the assembly of tight junctions (TJs), and adherens junctions (AJs), and driving epithelial wound healing. Actin filaments undergo a constant turnover guide
Externí odkaz:
https://doaj.org/article/90752bd185b04a1eb931a662eeb18208
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003879 (2013)
Retrotransposon sequences are positioned throughout the genome of almost every eukaryote that has been sequenced. As mobilization of these elements can have detrimental effects on the transcriptional regulation and stability of an organism's genome,
Externí odkaz:
https://doaj.org/article/14b2b83879b749bf80e13c42cbba05a6
Autor:
Michelle S Longworth, James A Walker, Endre Anderssen, Nam-Sung Moon, Andrew Gladden, Margarete M S Heck, Sridhar Ramaswamy, Nicholas J Dyson
Publikováno v:
PLoS Genetics, Vol 8, Iss 4, p e1002618 (2012)
Previously, we discovered a conserved interaction between RB proteins and the Condensin II protein CAP-D3 that is important for ensuring uniform chromatin condensation during mitotic prophase. The Drosophila melanogaster homologs RBF1 and dCAP-D3 co-
Externí odkaz:
https://doaj.org/article/2a9b9bba3f9a4ee6a3cedca7dfbcc536
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/f08ef460eced407ba232fbc1ae63a282
Autor:
Jacqueline R Ward, Afshin Khan, Sabrina Torres, Bert Crawford, Sarah Nock, Trenton Frisbie, John V Moran, Michelle S Longworth
Publikováno v:
Nucleic acids research. 50(18)
Condensin I and condensin II are multi-subunit complexes that are known for their individual roles in genome organization and preventing genomic instability. However, interactions between condensin I and condensin II subunits and cooperative roles fo
Autor:
Susana Lechuga, Alexander X. Cartagena‐Rivera, Afshin Khan, Bert I. Crawford, Vani Narayanan, Daniel E. Conway, Jaakko Lehtimäki, Pekka Lappalainen, Florian Rieder, Michelle S. Longworth, Andrei I. Ivanov
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Frontiers in Chemistry, Vol 3 (2015)
Retrotransposons are repetitive DNA sequences that are positioned throughout the human genome. Retrotransposons are capable of copying themselves and mobilizing new copies to novel genomic locations in a process called retrotransposition. While most
Externí odkaz:
https://doaj.org/article/125a84efff1a408ca3de329614d71fc0